Recombinant Human NT-3 growth factor receptor(NTRK3),partial

Code CSB-YP621947HU
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Source Yeast
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Code CSB-EP621947HU
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Source E.coli
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Code CSB-EP621947HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP621947HU
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Source Baculovirus
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Code CSB-MP621947HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names NTRK3
Uniprot No. Q16288
Alternative Names EC 2.7.10.1; ETS related protein neurotrophic receptor tyrosine kinase fusion; ETS related protein neurotrophic receptor tyrosine kinase fusion protein; ETV6 NTRK3 fusion ; GP145 TrkC ; gp145(trkC) ; GP145-TrkC; GP145TrkC ; Neurotrophic tyrosine kinase receptor type 3; Neurotrophin 3 receptor ; NT 3 growth factor receptor ; NT 3 growth factor receptor precursor ; NT 3 receptor; NT-3 growth factor receptor; Ntrk3; NTRK3_HUMAN; OTTHUMP00000192915; TRK C; Trk-C; TRKC; TrkC tyrosine kinase; Tyrosine kinase receptor C
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
Gene References into Functions
  1. High TrkC mRNA expression appears to be frequent in the sonic hedgehog subgroup and seems not to have a major effect on therapy responsiveness in medulloblastoma patients. PMID: 28695340
  2. Data show that neurotrophin 3 receptor TrkC acts as an activator in tumorigenicity and metastasis of colorectal cancer, and was frequently overexpressed in colorectal cancer (CRC) cells, patients' tumor samples. PMID: 28455963
  3. LINC00052 could regulate NTRK3 expression by forming complementary base pairing with miR-128 and miR-485-3p to reduce the luciferase activity of NTRK3 3'UTR. PMID: 27351280
  4. Case Reports: mammary analog secretory carcinoma of the thyroid gland with ETV6 rearrangement and ETV6-NTRK3 gene fusion. PMID: 27282352
  5. The prevalence of ETV6-NTRK3 kinase fusions were determined in papillary thyroid cancer of adult population PMID: 29046324
  6. We report the case of a patient with an initial diagnosis of salivary acinic cell carcinoma later reclassified as Mammary analogue secretory carcinoma after next-generation sequencing revealed an ETV6-NTRK3 fusion. PMID: 26884591
  7. 5 gastrointestinal stromal tumors cases lacking alterations in the KIT/PDGFRA/SDHx/RAS pathways, including two additional cases with FGFR1-TACC1 and ETV6-NTRK3 fusions, are reported. PMID: 27974047
  8. High expression of TrkC is associated with glioblastoma. PMID: 28402394
  9. Study found that copy number variations of NTRK3 were associated with platinum-sensitive and platinum-resistant recurrences. Amplification of NTRK3 perfectly predicted platinum-sensitive relapse of ovarian cancer. PMID: 28746220
  10. we demonstrate the expression of the ETV6-NTRK3 fusion oncogene in a small subset of inflammatory myofibroblastic tumors PMID: 27259007
  11. ETV6-NTRK3 translocated papillary thyroid carcinomas are locoregionally aggressive and can metastasize distantly. PMID: 28125451
  12. We report 6 cases of secretory carcinomas of the skin harboring the ETV6-NTRK3 gene fusion PMID: 27631515
  13. A subset of ALK-negative inflammatory myofibroblastic tumour (IMT) have rearrangement of ROS1, ETV6 or NTRK3 as a possible oncogenic mechanism. PMID: 26647767
  14. TrkC-miR2 as a novel regulator of Wnt signaling, which might be a candidate oncogenic colorectal cancer biomarker. PMID: 28100780
  15. Pilot study usee targeted exome sequencing in an attempt to discover novel candidate genes related to Internet Gaming Disorder. Despite a relatively small sample, the targeted exome sequencing was feasible and valuable and revealed that rs2229910 of NTRK3 may be a protective SNP against Internet Gaming Disorder. PMID: 27826991
  16. Case Report: ETV6-NTRK3 translocation in primary cutaneous mammary analog secretory carcinoma. PMID: 27763904
  17. the ETV6-NTRK3 fusion might identify a subset of gastrointestinal stromal tumours with peculiar clinicopathological characteristics PMID: 26606880
  18. TNS1, MET, and TRKC tyrosine-phosphorylated proteins are upregulated during epithelial-mesenchymal transition induced with TGF-beta, and predict the outcome in lung adenocarcinoma patients. PMID: 26216473
  19. SNPs in the NTRK3 gene, pain, physical activity, and fear of falling were directly associated with depressive symptoms in older adults. PMID: 26055783
  20. Molecular analysis of ETV6 gene rearranged mammary analogue secretory carcinoma of salivary glands tumors with lack of classical ETV6-NTRK3 fusion. PMID: 26492182
  21. Spectrum of secretory breast carcinoma with ETV6-NTRK3 gene fusion ranging from low-grade to high-grade histology, with occasional low hormonal receptor expression, simplex genomic profiles, and possible unfavorable course. PMID: 26291510
  22. The role of NTRK3 in in paranoid schizophrenia development in Russians. PMID: 26410934
  23. The overall percentage of NTRK3 gene methylation frequency with subsequent loss of mRNA expression was significantly higher in glioma compared with control samples. PMID: 24840578
  24. Experimental verification of a conserved intronic microRNA located in the human TrkC gene with a cell type-dependent apoptotic function. PMID: 25772499
  25. findings suggest a novel pathophysiological mechanism involving NTRK3 in the development of VSDs PMID: 25196463
  26. Report molecular genetic tests for ETV6-NTRK3 for differential diagnosis of mammary analogue secretory carcinoma of the salivary gland. PMID: 25456394
  27. ETV6-NTRK3 rearrangement can be directly induced in thyroid cells by ionizing radiation in vitro and, thus, may represent a novel mechanism of radiation-induced carcinogenesis. PMID: 24327398
  28. NTRK3 genetic variants may influence white matter integrity in brain regions implicated in neuropsychiatric disorders. PMID: 23727532
  29. Results show that TrkC plays physiological role in the pathogenesis of leukemia and have important implications for understanding various hematological malignancies. PMID: 23832765
  30. Report ETV6-NTRK3 gene fusion in mammary analogue secretory carcinoma of salivary glands with high-grade transformation. PMID: 24145651
  31. our findings suggest NTRK3 is a conditional tumor suppressor gene that is commonly inactivated in colorectal cancer by both epigenetic and genetic mechanisms PMID: 23874207
  32. Genetic evidence shows that TrkC and TrkB activation in early cortical neurons depends on transactivation by epidermal growth factor receptor signaling. PMID: 23416450
  33. provide evidence that a mutation of TrkC detected in a sporadic cancer is a loss-of-proapoptotic function mutation PMID: 23341610
  34. ShcD binds to TrkC in a kinase-activity-dependent manner through its PTB and SH2 domains. PMID: 20078941
  35. The significant expression of Trk isoforms among advanced neuroblastoma cases support their role as possible risk assessment tools alongside N-Myc amplification status. PMID: 21728718
  36. SOX2 utilizes a specific binding motif to directly interact with the TRKC regulatory region. PMID: 22265740
  37. TrkC is implicated as a functional PDNF receptor in cell entry, independently of sialic acid recognition, mediating broad T. cruzi infection both in vitro and in vivo. PMID: 21788388
  38. Low TRKC is associated with low vincristine and lomustine response in medulloblastoma. PMID: 21617231
  39. Mesenchymal stem cells modified by adenovirus carrying the TrkC gene are further promoted to differentiate into neuron-like cells with the potency of forming synapses by overexpressing the NT-3 gene in Schwann cells. PMID: 19680743
  40. We have characterized a novel ETV6-NTRK3 fusion transcript which has not been previously described in AML FAB M0 by FISH and RACE PCR. PMID: 21401966
  41. NT3 and its receptor may be involved in early folliculogenesis, particularly in the activation of primordial follicles. PMID: 21392742
  42. This study demonistrated that Intron 12 in NTRK3 is associated with bipolar disorder. PMID: 20554328
  43. Overexpression of TrkC is associated with breast tumor growth and metastasis. PMID: 20802235
  44. Findings suggest that mutations in RET and NTRK3 acting together are necessary and sufficient for the appearance of Hirschsprung disease and the EDN3 mutation acts as a phenotype modifier. PMID: 19556619
  45. Study identified the previously reported pathogenic mutation of NTRK3 in a KRAS/BRAF wild-type tumor and 2 somatic mutations in the Src family of kinases (YES1 and LYN) that would be expected to cause structural changes. PMID: 19893451
  46. Although TrkB and TrkC signals mediating survival are largely similar, TrkB and TrkC signals required for maintenance of target innervation in vivo are regulated by distinct mechanisms. PMID: 11877382
  47. Expression of the ETV6-NTRK3 gene fusion is a primary event in human secretory breast carcinoma. PMID: 12450792
  48. ETV6-NTRK3.IRS-1 complex formation through the NTRK3 C terminus is essential for ETV6-NTRK3 transformation PMID: 14668342
  49. While survival rates were higher for patients with high TrkC expression, these differences were not statistically significant. PMID: 15198123
  50. truncated trkC is prevalent in the human prefrontal cortex and that neurons and glia may be responsive to NT-3 throughout life PMID: 15932601

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Involvement in disease Defects in NTRK3 are associated with susceptibility to congenital heart defects (CHD). A disease characterized by congenital developmental abnormalities involving structures of the heart. CHD are the most common major birth defects and the leading cause of death from congenital malformations.
Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
Tissue Specificity Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.
Database Links

HGNC: 8033

OMIM: 191316

KEGG: hsa:4916

STRING: 9606.ENSP00000354207

UniGene: Hs.185701

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