Name: Recombinant Human Neural cell adhesion molecule 1(NCAM1),partial
Brand: CUSABIO
SKU: CSB-EP015511HU1

Product Details

Purity	Greater than 85% as determined by SDS-PAGE.
Target Names	NCAM1
Uniprot No.	P13591
Research Area	Neuroscience
Alternative Names	antigen MSK39 identified by monoclonal 5.1H11; antigen recognized by monoclonal 5.1H11; CD56; cell adhesion molecule, neural, 1; MSK 39; MSK39; N-CAM-1; NCAM 1; NCAM; NCAM C; NCAM-1; NCAM1; NCAM1_HUMAN; NCAMC; Neural cell adhesion molecule 1; Neural cell adhesion molecule NCAM; OTTHUMP00000235666
Species	Homo sapiens (Human)
Source	E.coli
Expression Region	31-677aa
Target Protein Sequence	ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAE Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight	75.9 kDa
Protein Length	Partial of isform 2
Tag Info	N-terminal 6xHis-tagged
Form	Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer	If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Note: If you have any special requirement for the glycerol content, please remark when you place the order. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs	Protein FAQs
Storage Condition	Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time	3-7 business days
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA	Please contact us to get it.

Target Background

Function (From Uniprot)	This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.; (Microbial infection) Acts as a receptor for rabies virus.; (Microbial infection) Acts as a receptor for Zika virus.
Gene References into Functions	CD56 is a potentially good immunohistochemical marker for differentiating papillary thyroid carcinoma from other benign follicular lesions of the thyroid PMID: 30173227 TROP-2, SLP-2 and CD56 were effective diagnostic markers for PTC, especially when they were combined to use. PMID: 29951933 evaluation of the diagnostic value of emerin and CD56 in papillary thyroid carcinoma, using immunohistochemistry PMID: 30188764 Plasma levels of NCAM-1 were found to be lower in coronary artery disease patients compared to controls. PMID: 29506702 CD200(+) and/or CD56(+) positive expression in B-ALL patients at diagnosis is a poor prognostic biomarker. PMID: 29161980 CD56 immunohistochemistry can be useful in differentiating follicular variant papillary thyroid carcinoma from follicular adenoma. PMID: 29799356 NCAM1 protein expression levels were found to be regulated by miRNA-572 in an oligodendroglial cell line. PMID: 28332001 a role for CD56 in developmental synapse structure, natural killer (NK) cell motility and NK cell development. PMID: 27435370 The expression of CD56 was analyzed in 74 samples of primary MM cells collected from patients before they received bortezomib plus dexamethasone therapy. Expression of NCAM was lower among patients who responded poorly. In vitro expression of NCAM induced by transfection of MM cells enhanced their sensitivity to Btz treatment by causing accumulation of polyubiquitinated proteins. PMID: 29738534 Results show that the conjugate selectively depleted the CSC population of the tumors and effectively inhibited tumor growth without causing toxicity. We propose that the NCAM-targeted conjugate could be an effective therapeutic for Wilms tumor. PMID: 28729402 CD200 and/or CD56 positive expression in B-ALL at diagnosis suggest a poor prognosis and may be associated with biological aggressiveness. PMID: 29144828 This study concludes that the cytotoxic action of CD56+ fraction of cytokine-induced killer cells against a K562 cell line is mainly due to the natural killer cells. PMID: 27136441 NCAM1 was up-regulated in the malignant Middle Cerebral Artery Infarction. PMID: 28828208 This supports the conclusion that a lower proportion of CD56(bright) natural killer regulatory cells results in the high rate of chronic graft-versus-host disease seen in filgrastim-stimulated apheresis peripheral blood. PMID: 28935847 inhibiting NCAM1 would be cardioprotective, counteract the pathological action of TGFbeta1 and reduce heart failure severity. PMID: 28870505 Mutation of a putative MAP kinase (Erk2) consensus site regulates neural cell adhesion molecule (NCAM) endocytosis and NCAM-dependent neurite outgrowth. PMID: 28193531 The combined use of CK19 and CD56 is helpful in discriminating papillary thyroid carcinoma and its variants from other mimicking thyroid lesions. PMID: 28214214 NCAM-expression in adult dilated cardiomyopathy hearts is associated with cardiomyocyte hypertrophy. PMID: 28343767 This study identified NCAM1 gene sets related to self-reported depression scores in healthy participants PMID: 28334615 Basal cell carcinoma (BCC) typically shows patchy CD56 expression and diffuse CK5/6 positivity. These 2 markers can be used to distinguish between BCC and Merkel cell carcinoma in challenging cases. PMID: 28403527 Study represents the first to evaluate the prognostic impact of CD56 expression in a real-life setting and address these findings to a large and heterogeneous subset of AML. PMID: 26914377 T-cell differentiation and CD56+ levels are different in polypoidal choroidal vasculopathy and neovascular age-related macular degeneration. PMID: 29165313 findings that the CD56 and CD117 expression levels are lower in advanced stages than earlier stages and that LDH level and CD117 expression have an inverse relationship in patients with newly diagnosed multiple myeloma (MM) suggest that CD56 and CD117 expressions may be prognostic markers for MM. PMID: 28270374 soluble NCAM might be thought as a specific marker of peripheral nerve demyelination and as a sensitive marker of peripheral nerve injuries PMID: 28336415 Neural cell adhesion molecule (NCAM, CD56) is a transmembrane glycoprotein. PMID: 27528376 Suggest that INSM1 is valuable for identification of the high-grade thoracic neuroendocrine carcinomas that are sometimes negative for synaptophysin, chromogranin, and CD56. PMID: 28719469 CD56(bright) NK IL-7Ralpha expression negatively associates with HCV level, and IL-7-induced NK function is impaired during HCV and HIV infections PMID: 28400540 These findings provide evidence for newly-discovered roles for PREP in mechanisms regulating cellular plasticity through NCAM and PSA-NCAM. PMID: 27566163 NCAM- and FGF-2-mediated FGFR1 signaling in the tumor microenvironment regulates the survival and migration of esophageal squamous carcinoma cells. PMID: 27317650 Study provides detailed description of the PSA-NCAM distribution throughout the human brain and quantitatively compares control, Alzheimer's and Parkinson's disease. Results demonstrate that PSA-NCAM-mediated structural plasticity may not be limited to neurogenic niches and is conserved in the aged brain, provide evidence that PSA-NCAM is reduced in the entorhinal cortex. PMID: 27282086 The purpose of this study is to reveal whether neural cell adhesion molecule (NCAM) mediates the protective effects of GDNF. PMID: 27003822 Suppressor function of CD56bright NK cells is impaired in multiple sclerosis. PMID: 27157273 data provided molecular details about the interaction between HuPrP and the NCAM fibronectin domain, and revealed a new role of PrP(C) N terminus as a dynamic and functional element responsible for protein-protein interaction. PMID: 27535221 The polybasic region of the polysialyltransferase ST8Sia-IV binds directly to NCAM. PMID: 28233978 analysis of structural and genetic features of the CD56 glycoprotein, and summary of its roles in the normal versus diseased metanephric blastema [review] PMID: 27935326 novel RUNX1 isoforms contribute in controlling CD56 expression in acute myeloid leukemia cells. PMID: 26706848 NCAM1 SNPs were associated with lifetime cannabis use, but the association did not reach genome-wide significance. [Meta-Analysis] PMID: 27023175 analysis of natural killer cell markers in renal transplantation that have roles in acute rejection reveals that CD56 and CD57 are increased in the interstitial compartment in donor-specific antibody (DSA)-negative biopsies from patients with acute antibody-mediated rejection without C4d, and CD16 is increased in the glomerular compartment in DSA-positive biopsies PMID: 26615051 Data show that negative selection for CD133 is required for defining NCAM1(+) nephron stem cells in normal and malignant nephrogenesis. PMID: 27020553 Report increased CD56 expression by immature biliary epithelial cells in biliary atresia. PMID: 26937142 NCAM1 deletion is associated with neuroblastoma and ganglioneuroma. PMID: 26463893 this study shows that CD56 expression defines a poor prognosis subset in the cytogenetically intermediate prognosis pediatric AML. PMID: 26147745 The expression of coding and non-coding genes with SAFB1 cross-link sites was altered by SAFB1 knockdown. The isoform-specific expression of neural cell adhesion molecule (NCAM1) and ASTN2 was influenced by SAFB1. PMID: 26694817 the expression of CD56 in adenomyosis is positively associated with the severity of dysmenorrhea. PMID: 26344352 A FOXP3(+)CD3(+)CD56(+)-expressed T-cell population with immunosuppressive function and reduced patient survival has been identified in cancer tissues of human hepatocellular carcinoma. PMID: 26437631 NK cell maturation to CD56(dim) subset associated with high levels of NCRs overrides the inhibitory effect of NKG2A and recovers impaired NK cell cytolytic potential after allogeneic hematopoietic stem cell transplantation. PMID: 26856773 The neural cell adhesion molecule (NCAM) is a glycoprotein implicated in cell-cell adhesion, neurite outgrowth and synaptic plasticity. PMID: 26460482 L1-CAM and N-CAM: From Adhesion Proteins to Pharmacological Targets PMID: 26478212 CD56 marker is a useful alternative that is comparable to SSTR2A for the diagnosis of phosphaturic mesenchymal tumors. PMID: 26339384 Case Report: chronic lymphocytic leukemia with aberrant CD56 and CD57 expression. PMID: 26013700 Show More Hide All
Subcellular Location	[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform 4]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform 5]: Secreted.; [Isoform 6]: Secreted.
Database Links	HGNC: 7656 OMIM: 116930 KEGG: hsa:4684 STRING: 9606.ENSP00000318472 UniGene: Hs.503878

CloseMessage

Product >> Product Name：
Product >> Code：
Product >> Size：
Name： *
Email： *
Phone：
We recommend you to leave your phone number because occasionally our emails get flagged by spam filters. We would not disclose any of your private information to any third party.
Question/Comment： *
Your Region： *
Country State：
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
Check Code：

Code	CSB-EP015511HU1
Size	US$578Purchase it in Cusabio online store (only available for customers from the US)
Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Have Questions?	Leave a Message or Start an on-line Chat

Recombinant Human Neural cell adhesion molecule 1(NCAM1),partial

Product Details

Related Products

Customer Reviews and Q&A

Target Background

CloseMessage

×CloseMessage