Recombinant Human Neurogenic differentiation factor 1 (NEUROD1)

1. Data suggest that the first cases of MODY6 identified in Japan are result of missense (p.L157R, c.470T>G) or frameshift mutations (p.H206PfsTer38, c.616_617insC; p.P245RfsTer17, c.734delC; p.H206TfsTer56, c.616delC) in NEUROD1. The probands and affected family members exhibit intrinsically lower capacity of insulin secretion and neurological disorders. [CASE REPORT] PMID: 28664602
2. Data suggest the EGR1-miR-30a-5p-NEUROD1 axis might serve as a promising biomarker for diagnosis and treatment monitoring for schizophrenic patients in acute psychotic state. EGR1 and miR-30a-5p were remarkably downregulated, whereas NEUROD1 was significantly upregulated in PBMNCs from patients in acute psychotic state. PMID: 28072411
3. Mutation in NEUROD1 gene is associated with Maturity Onset Diabetes of the Young. PMID: 28095440
4. the importance of the oligomeric state of CtBP for coactivation of NeuroD1-dependent transcription, was investigated. PMID: 27880001
5. NeuroD1 seemed not sufficient to induce and maintain neuronal differentiation. Induction of neuronal differentiation by overexpression of Neurog1 initiated important steps for the development of glutamatergic neurons such as the spiral ganglion neurons PMID: 27423984
6. detected c.133A > G (p. Ala45Thr) in children with sensorineural hearing loss PMID: 26634621
7. Study reports a family with autosomal dominant diabetes related to a new NEUROD1 mutation, one of very few meeting Maturity Onset Diabetes of the Young criteria. PMID: 26773576
8. RNAi of lentiviral vector target NeuroD can reduce the migration and invasion abilities of PANC-1 cells PMID: 24464628
9. this study concludes that the novel mechanism would regulate the expression of ALK in neuroblastoma and that NeuroD1 should be significantly involved in neuroblastoma tumorigenesis. PMID: 25652313
10. NEUROD1 is important for maintenance of the retina function and partial loss-of-function mutation in NEUROD1 is likely a rare cause of nonsyndromic ARRP. PMID: 25477324
11. Increased expression of NeuroD1 subsequently leads to regulation of expression and function of the nicotinic acetylcholine receptor subunit cluster of alpha3, alpha5, and beta4. PMID: 24719457
12. Transactivation of Ctbp was dependent on the histone H3 lysine 9 (H3K9) demethylase activity of LSD1 facilitates subsequent H3K9 acetylation by the NeuroD1-associated histone acetyltransferase, P300/CBP-associated factor. PMID: 24732800
13. The variant A45T does not play a major role in the development of T2 Diabetes mellitus in East Asian descent. PMID: 23203005
14. Gene expression profiling revealed that permissive lines are typified by lower expression of the early neurogenic transcription factor ASCL1 and, conversely, by higher expression of the late neurogenic transcription factor NEUROD1. PMID: 23739064
15. NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM. PMID: 23553831
16. The overexpression of NeuroD may contribute to the tumorogenesis and development of pancreatic carcinoma, and is closely correlated to the cancer cell proliferation, p53 signal pathway and neural invasion. PMID: 22455846
17. Combined transfection of the three transcriptional factors, PDX-1, NeuroD1, and MafA, causes differentiation of bone marrow mesenchymal stem cells into insulin-producing cells PMID: 22761608
18. Photosensitive photoreceptor cells can be generated by combinations of transcription factors. The combination of CRX and RX generate immature photoreceptors: and additional NEUROD promotes maturation. PMID: 22558175
19. Most, if not all, nasal chemosensory neurons derive from NeuroD1-expressing globose basal cells of the immediate neuronal precursor variety. PMID: 21800309
20. Findings establish the critical role of the neuronal differentiation factor NeuroD1 in neuroblastoma as well as its functional relationship with the neuronal repellent factor Slit2. PMID: 21349947
21. ATF2 interacts with beta-cell-enriched transcription factors, MafA, Pdx1, and beta2, and activates insulin gene transcription. PMID: 21278380
22. NeuroD alone may not be sufficient to induce regulated insulin release in insulin-producing liver cells. PMID: 21084850
23. Human NeuroD1 under control of the cytokeratin 19 promoter can induce differerentiation of pancreatic epithelial cells into insulin producing cells. PMID: 20692411
24. syndrome resulting from homozygous loss of function mutations in NEUROD1 which is characterized by permanent neonatal diabetes. PMID: 20573748
25. There was no association between methylation and expression in breast tumour specimens, with only 14% exhibiting NEUROD1 expression PMID: 19353266
26. No significant association of NEUROD1 with retinopathy or nephropathy in Croatian patients with type I diabetes PMID: 20120526
27. regulator of insulin transcription PMID: 11755474
28. expression during trophoblast invasion PMID: 11900979
29. Beta-cell dysfunction in late-onset diabetic subjects carrying homozygous mutation in transcription factor NeuroD1. PMID: 12200761
30. The genetic polymorphism in NeuroD is associated with the development of early-onset type 2 diabetes. The presence of Thr45 allele may represent a risk factor for early-onset type 2 diabetes among Chinese. PMID: 12476420
31. Polymorphism Ala45Thr is associated with Type 1 diabetes mellitus in Czech children PMID: 12639765
32. Ala5Thr polymorphism of NeuroD1 plays a role in the risk of NIDDM in the examined Polish population PMID: 12861411
33. NeuroD1/E47 transcription factors up-regulate IA-1 gene expression through the proximal E-box element of the IA-1 promoter PMID: 12890672
34. Ala45 variant of BETA2/NeuroD1 may be associated with IDDM in Caucasians. PMID: 12951629
35. NeuroD1 is differentially expressed in pituitary adenomas and its possible ontogenetic and/or pathogenetic implications in non-corticotroph tumors are discussed. PMID: 14759067
36. No evidence of Ala(45)Thr polymorphism of the NeueroD gene and type 1 diabetes. PMID: 15047635
37. Focus of this review is on recent progress in understanding the important role of BETA2/NeuroD1 in initiating neuronal differentiation and maintaining the nervous system. PMID: 15247487
38. Polymorphism contributes to glucose intolerance in a South Indian population. PMID: 15277395
39. NeuroD controls both common and distinct sets of molecules involved in cell survival and differentiation in different tissue types [review] PMID: 15650322
40. co-expression and functional synergism of these beta-cell enriched transactivators, MafA, Pdx1, and Beta2, are critical for establishing the beta-cell-specific and efficient expression of the insulin gene. PMID: 15993959
41. the SREBP-1c.BETA2.E47 complex is in a DNA looping structure which is required for efficient recruitment of CREB-binding protein/p300 PMID: 16055439
42. we demonstrated that ISL1 and BETA2 could activate insulin gene transcription synergistically. PMID: 16321656
43. Gender-specific association of the Ala45Thr variant of NEUROD1 with Type 1 diabetes in Brazilian women. PMID: 16357810
44. results presented in this study define INSM1 as a transcriptional repressor of the neuroD/b2 gene. The molecular mechanism of INSM1 transcriptional repression is attributed to the recruitment of cyclin D1 and HDAC-1 and -3 PMID: 16569215
45. The NeuroD1-Ala45Thr variation may itself have an important role in susceptibility to or be in disequilibrium with early-onset T2DM in Chinese. The Ala45Thr may affect the onset pattern of T2DM, i.e., early-onset but not late-onset T2DM in Chinese. PMID: 16773428
46. helix-loop-helix (HLH) domain of basic helix-loop-helix (bHLH) family proteins such as NeuroD facilitate protein transduction into various cell lines. PMID: 16870135
47. Expression of NeuroD1 versus chromogranin-A is more frequent in pCA, and correlates to increased indicators of malignancy in moderately to poorly differentiated pCA. PMID: 17126478
48. These results suggest that NeuroD plays an important role in regulated exocytosis by inducing expressions of various components required in the process. PMID: 17217914
49. A study evaluating the extent to which common variation in the six known maturity-onset diabetes of the young (MODY) genes, which cause a monogenic form of type 2 diabetes, is associated with type 2 diabetes is presented. PMID: 17327436
50. Mutation in the NeuroD1/BETA2 gene contributes to the development of diabetes PMID: 17440689

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HGNC: 7762

OMIM: 125853

KEGG: hsa:4760

STRING: 9606.ENSP00000295108

UniGene: Hs.574626