Recombinant Human Neurogenic differentiation factor 1(NEUROD1)

Code CSB-YP615700HU
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Source Yeast
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Code CSB-EP615700HU
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Source E.coli
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Code CSB-EP615700HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP615700HU
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Source Baculovirus
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Code CSB-MP615700HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names NEUROD1
Uniprot No. Q13562
Alternative Names atonal; basic helix loop helix transcription factor; BETA 2; Beta cell E box transactivator 2; BETA2; BHF 1; BHF1; bHLHa3; class A basic helix loop helix protein 3; Class A basic helix-loop-helix protein 3; MODY 6; MODY6; NDF1_HUMAN; NeuroD; NeuroD1; Neurogenic differentiation 1; Neurogenic differentiation factor 1; neurogenic helix loop helix protein NEUROD; Neuronal differentiation 1
Species Homo sapiens (Human)
Expression Region 1-356
Target Protein Sequence MTKSYSESGL MGEPQPQGPP SWTDECLSSQ DEEHEADKKE DDLETMNAEE DSLRNGGEEE DEDEDLEEEE EEEEEDDDQK PKRRGPKKKK MTKARLERFK LRRMKANARE RNRMHGLNAA LDNLRKVVPC YSKTQKLSKI ETLRLAKNYI WALSEILRSG KSPDLVSFVQ TLCKGLSQPT TNLVAGCLQL NPRTFLPEQN QDMPPHLPTA SASFPVHPYS YQSPGLPSPP YGTMDSSHVF HVKPPPHAYS AALEPFFESP LTDCTSPSFD GPLSPPLSIN GNFSFKHEPS AEFEKNYAFT MHYPAATLAG AQSHGSIFSG TAAPRCEIPI DNIMSFDSHS HHERVMSAQL NAIFHD
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Acts as a transcriptional activator
Gene References into Functions
  1. Data suggest that the first cases of MODY6 identified in Japan are result of missense (p.L157R, c.470T>G) or frameshift mutations (p.H206PfsTer38, c.616_617insC; p.P245RfsTer17, c.734delC; p.H206TfsTer56, c.616delC) in NEUROD1. The probands and affected family members exhibit intrinsically lower capacity of insulin secretion and neurological disorders. [CASE REPORT] PMID: 28664602
  2. Data suggest the EGR1-miR-30a-5p-NEUROD1 axis might serve as a promising biomarker for diagnosis and treatment monitoring for schizophrenic patients in acute psychotic state. EGR1 and miR-30a-5p were remarkably downregulated, whereas NEUROD1 was significantly upregulated in PBMNCs from patients in acute psychotic state. PMID: 28072411
  3. Mutation in NEUROD1 gene is associated with Maturity Onset Diabetes of the Young. PMID: 28095440
  4. the importance of the oligomeric state of CtBP for coactivation of NeuroD1-dependent transcription, was investigated. PMID: 27880001
  5. NeuroD1 seemed not sufficient to induce and maintain neuronal differentiation. Induction of neuronal differentiation by overexpression of Neurog1 initiated important steps for the development of glutamatergic neurons such as the spiral ganglion neurons PMID: 27423984
  6. detected c.133A > G (p. Ala45Thr) in children with sensorineural hearing loss PMID: 26634621
  7. Study reports a family with autosomal dominant diabetes related to a new NEUROD1 mutation, one of very few meeting Maturity Onset Diabetes of the Young criteria. PMID: 26773576
  8. RNAi of lentiviral vector target NeuroD can reduce the migration and invasion abilities of PANC-1 cells PMID: 24464628
  9. this study concludes that the novel mechanism would regulate the expression of ALK in neuroblastoma and that NeuroD1 should be significantly involved in neuroblastoma tumorigenesis. PMID: 25652313
  10. NEUROD1 is important for maintenance of the retina function and partial loss-of-function mutation in NEUROD1 is likely a rare cause of nonsyndromic ARRP. PMID: 25477324
  11. Increased expression of NeuroD1 subsequently leads to regulation of expression and function of the nicotinic acetylcholine receptor subunit cluster of alpha3, alpha5, and beta4. PMID: 24719457
  12. Transactivation of Ctbp was dependent on the histone H3 lysine 9 (H3K9) demethylase activity of LSD1 facilitates subsequent H3K9 acetylation by the NeuroD1-associated histone acetyltransferase, P300/CBP-associated factor. PMID: 24732800
  13. The variant A45T does not play a major role in the development of T2 Diabetes mellitus in East Asian descent. PMID: 23203005
  14. Gene expression profiling revealed that permissive lines are typified by lower expression of the early neurogenic transcription factor ASCL1 and, conversely, by higher expression of the late neurogenic transcription factor NEUROD1. PMID: 23739064
  15. NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM. PMID: 23553831
  16. The overexpression of NeuroD may contribute to the tumorogenesis and development of pancreatic carcinoma, and is closely correlated to the cancer cell proliferation, p53 signal pathway and neural invasion. PMID: 22455846
  17. Combined transfection of the three transcriptional factors, PDX-1, NeuroD1, and MafA, causes differentiation of bone marrow mesenchymal stem cells into insulin-producing cells PMID: 22761608
  18. Photosensitive photoreceptor cells can be generated by combinations of transcription factors. The combination of CRX and RX generate immature photoreceptors: and additional NEUROD promotes maturation. PMID: 22558175
  19. Most, if not all, nasal chemosensory neurons derive from NeuroD1-expressing globose basal cells of the immediate neuronal precursor variety. PMID: 21800309
  20. Findings establish the critical role of the neuronal differentiation factor NeuroD1 in neuroblastoma as well as its functional relationship with the neuronal repellent factor Slit2. PMID: 21349947
  21. ATF2 interacts with beta-cell-enriched transcription factors, MafA, Pdx1, and beta2, and activates insulin gene transcription. PMID: 21278380
  22. NeuroD alone may not be sufficient to induce regulated insulin release in insulin-producing liver cells. PMID: 21084850
  23. Human NeuroD1 under control of the cytokeratin 19 promoter can induce differerentiation of pancreatic epithelial cells into insulin producing cells. PMID: 20692411
  24. syndrome resulting from homozygous loss of function mutations in NEUROD1 which is characterized by permanent neonatal diabetes. PMID: 20573748
  25. There was no association between methylation and expression in breast tumour specimens, with only 14% exhibiting NEUROD1 expression PMID: 19353266
  26. No significant association of NEUROD1 with retinopathy or nephropathy in Croatian patients with type I diabetes PMID: 20120526
  27. regulator of insulin transcription PMID: 11755474
  28. expression during trophoblast invasion PMID: 11900979
  29. Beta-cell dysfunction in late-onset diabetic subjects carrying homozygous mutation in transcription factor NeuroD1. PMID: 12200761
  30. The genetic polymorphism in NeuroD is associated with the development of early-onset type 2 diabetes. The presence of Thr45 allele may represent a risk factor for early-onset type 2 diabetes among Chinese. PMID: 12476420
  31. Polymorphism Ala45Thr is associated with Type 1 diabetes mellitus in Czech children PMID: 12639765
  32. Ala5Thr polymorphism of NeuroD1 plays a role in the risk of NIDDM in the examined Polish population PMID: 12861411
  33. NeuroD1/E47 transcription factors up-regulate IA-1 gene expression through the proximal E-box element of the IA-1 promoter PMID: 12890672
  34. Ala45 variant of BETA2/NeuroD1 may be associated with IDDM in Caucasians. PMID: 12951629
  35. NeuroD1 is differentially expressed in pituitary adenomas and its possible ontogenetic and/or pathogenetic implications in non-corticotroph tumors are discussed. PMID: 14759067
  36. No evidence of Ala(45)Thr polymorphism of the NeueroD gene and type 1 diabetes. PMID: 15047635
  37. Focus of this review is on recent progress in understanding the important role of BETA2/NeuroD1 in initiating neuronal differentiation and maintaining the nervous system. PMID: 15247487
  38. Polymorphism contributes to glucose intolerance in a South Indian population. PMID: 15277395
  39. NeuroD controls both common and distinct sets of molecules involved in cell survival and differentiation in different tissue types [review] PMID: 15650322
  40. co-expression and functional synergism of these beta-cell enriched transactivators, MafA, Pdx1, and Beta2, are critical for establishing the beta-cell-specific and efficient expression of the insulin gene. PMID: 15993959
  41. the SREBP-1c.BETA2.E47 complex is in a DNA looping structure which is required for efficient recruitment of CREB-binding protein/p300 PMID: 16055439
  42. we demonstrated that ISL1 and BETA2 could activate insulin gene transcription synergistically. PMID: 16321656
  43. Gender-specific association of the Ala45Thr variant of NEUROD1 with Type 1 diabetes in Brazilian women. PMID: 16357810
  44. results presented in this study define INSM1 as a transcriptional repressor of the neuroD/b2 gene. The molecular mechanism of INSM1 transcriptional repression is attributed to the recruitment of cyclin D1 and HDAC-1 and -3 PMID: 16569215
  45. The NeuroD1-Ala45Thr variation may itself have an important role in susceptibility to or be in disequilibrium with early-onset T2DM in Chinese. The Ala45Thr may affect the onset pattern of T2DM, i.e., early-onset but not late-onset T2DM in Chinese. PMID: 16773428
  46. helix-loop-helix (HLH) domain of basic helix-loop-helix (bHLH) family proteins such as NeuroD facilitate protein transduction into various cell lines. PMID: 16870135
  47. Expression of NeuroD1 versus chromogranin-A is more frequent in pCA, and correlates to increased indicators of malignancy in moderately to poorly differentiated pCA. PMID: 17126478
  48. These results suggest that NeuroD plays an important role in regulated exocytosis by inducing expressions of various components required in the process. PMID: 17217914
  49. A study evaluating the extent to which common variation in the six known maturity-onset diabetes of the young (MODY) genes, which cause a monogenic form of type 2 diabetes, is associated with type 2 diabetes is presented. PMID: 17327436
  50. Mutation in the NeuroD1/BETA2 gene contributes to the development of diabetes PMID: 17440689

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Involvement in disease Maturity-onset diabetes of the young 6 (MODY6); Diabetes mellitus, non-insulin-dependent (NIDDM)
Subcellular Location Cytoplasm, Nucleus
Database Links

HGNC: 7762

OMIM: 125853

KEGG: hsa:4760

STRING: 9606.ENSP00000295108

UniGene: Hs.574626

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