Recombinant Human Olfactomedin-4 (OLFM4)

1. Study results suggest that OLFM4, LY6D and S100A7 immunoreactivity are associated with an aggressive phenotype of estrogen receptor (ER)-positive breast carcinoma, and these are potent markers for distant metastasis of ER-positive breast cancer patients. PMID: 30137688
2. these data propose that hCG is not a key regulator of cellular alterations within peripheral blood dendritic cells PMID: 29488661
3. discovered that OLFM4, CD11b, and ITGA2 are proteins that are overexpressed in both primary colon tumors and liver metastasis. These are colon cancer biomarkers with autoantigenic properties. PMID: 28669815
4. MiR-103 acts as an oncogene miRNA to promote triple-negative breast cancer cells migration and invasion through targeting OLFM4. PMID: 28320108
5. OLFM4 has an important role in the regulation of intestinal inflammation and tumorigenesis, and could be a potential therapeutic target for intestinal malignant tumors. Unlike the human colonic epithelium, the mouse colonic epithelium does not express OLFM4, but nevertheless, systemic OLFM4 deletion promotes colon tumorigenesis and that loss from mucosal neutrophils may have a role to play. PMID: 26973250
6. Olfactomedin-4 identifies a subpopulation of neutrophils in patients with septic shock, and those with a high percentage of olfactomedin-4+ neutrophils are at higher risk for greater organ failure burden and death. Olfactomedin-4 might serve as a marker of a pathogenic neutrophil subset in patients with septic shock PMID: 27635771
7. OLFM4 is proved to as a functional target for miR-590. PMID: 28012926
8. Olfactomedin 4 is a novel tumor marker for triple-negative breast cancer for predicting and prognosis. PMID: 27939521
9. OLFM4 is downregulated by miR-486-5p, which contributes to ovarian cancer tumorigenesis. Conversely, estrogen receptor signaling downregulates miR-486-5p and upregulates OLFM4 expression, slowing the development and progression of ovarian cancer. PMID: 26871282
10. Data show that olfactomedin 4 (OLFM4) is highly expressed in proliferating benign epithelial cells and in some carcinoma cells. PMID: 26416558
11. olfactomedin 4 appears to play a critical role in regulating progression of prostate cancer, and has potential as a new biomarker for prostate cancer. PMID: 26581960
12. Study demonstrates that epigenetic silencing of OLFM4 enhances gastric cancer cell invasion via activation of FAK signaling. PMID: 26303970
13. suppression of OLFM4 expression may be a promising strategy in the development of novel cancer therapeutic drugs PMID: 26398045
14. Patients with an OLFM4 gene expression level above -7.5 were 6 times more likely to develop severe disease, after correction for age at hospitalization and gestational age. PMID: 26162090
15. Using a human vaginal epithelial cell line, the expression of mucin 5 subtype B and olfactomedin-4 were down-regulated in response to N9, suggesting these markers could apply to humans PMID: 25333937
16. findings suggest that OLFM4 is not only involved in early stages of gastric carcinogenesis but also a useful prognostic marker for advanced gastric cancer PMID: 26070873
17. OLM4 expression is increased in the early stages of gastric, colorectal, and pancreatic cancer initiation. PMID: 25400027
18. High expression of GW112 in colorectal cancer tissues and reduced expression of GRIM-19 in colorectal cancer tissues may be associated with abnormal proliferation of cancer cells. PMID: 26011333
19. although low OLFM4 expression is not an independent prognostic biomarker, it might indicate worse prognosis for smoking patients with non-small cell lung cancer PMID: 25771901
20. Impairment of ERalpha signal-mediated OLFM4 expression promoted the malignant progression of endometrioid adenocarcinoma. PMID: 24495253
21. OLFM4 is a novel candidate tumor-suppressor gene for chromosome 13q and may shed new light on strategies that could be used for the diagnosis, prognosis, and treatment of prostate cancer patients. PMID: 24070418
22. Reduced expression of olfactomedin 4 and ectopic expression of claudin-18 might be useful markers in the differential diagnosis of serrated polyps. PMID: 23570326
23. OLFM4 is overexpressed in active IBD and secreted into mucus. OLFM4 seems to be of functional relevance in IBD as a mucus component, possibly by binding defensins. PMID: 22398066
24. OLFM4 regulates host defense against a broad range of bacteria including Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli in an OLFM4-deficient mouse model. PMID: 22844115
25. depletion of OLFM4 significantly inhibits tumorigenicity of the gastric cancer SGC-7901 and MKN45 cells. Blocking OLFM4 expression can sensitize gastric cancer cells to H2O2 or TNF alpha treatment by increasing caspase-3 dependent apoptosis. PMID: 22471589
26. Single nucleotide polymorphism in OLFM4 gene is associated with childhood obesity. PMID: 22484627
27. OLFM4 identifies a subset of human neutrophils. PMID: 22187488
28. Our results also indicate that OLFM4 is regulated by the Ras-NF-kappaB2 pathway, one of the main oncogenic pathways deregulated in colorectal tumors PMID: 21986994
29. Results suggest that S100B, TM4SF3, and OLFM4 overexpression may affect metastatic behavior of tumor cells in Taiwanese colorectal cancer patients. PMID: 22011044
30. The expression of OLFM4 mRNA or protein differed significantly among gastric tumor tissue, matched normal gastric mucosa, and lymph node metastases. PMID: 21904905
31. OLFM4 expression and its biological significances in tumor differentiation and progression as well as the contributions of OLFM4 to tumorigenesis (Review) PMID: 21067260
32. protection of AGT and resistance to nitrosamine-induced genotoxicity critically depends on GSNOR in hepatocytes PMID: 21470957
33. miR-486 antioncogenic activity may involve the direct targeting and inhibition of OLFM4. PMID: 21415212
34. Olfactomedin 4 expression has been associated with progression of cervical intraepithelial neoplasia and differentiation of cervical cancer. PMID: 21270618
35. Results show that cross-talk between estrogen and EGF signaling regulates OLFM-4 expression in human endometrium. PMID: 21048224
36. Review critically evaluates recent advances in understanding of the transcriptional regulation of OLFM4 and its upstream signalling pathways with special emphasis on carcinogenesis and outline future perspectives in the field PMID: 20878207
37. OLFM4 plays an important role in myeloid leukemia cellular functions PMID: 20724538
38. Data show that granulocyte colony stimulating factor stimulated clone-1, an extracellular matrix glycoprotein, facilitates cell adhesion. PMID: 16566923
39. The expression pattern of hGC-1 protein in 173 cases of gastric carcinoma was investigated and a striking correlation was demonstrated between hGC-1 expression and histological type and differentiation of gastric carcinoma. PMID: 17650212
40. hGC-1 may be a useful marker for tumor differentiation and progression of human colon carcinoma. PMID: 18281536
41. We generated human monoclonal antibodies against 2 potential tumor targets, NGAL and GW112, and we proved their selective expression in cancer colon and not or barely in healthy tissues. PMID: 18798264
42. OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells. PMID: 19450592
43. High serum olfactomedin 4 is associated with gastric cancer. PMID: 19670418

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HGNC: 17190

OMIM: 614061

KEGG: hsa:10562

STRING: 9606.ENSP00000219022

UniGene: Hs.508113