Recombinant Human Ornithine decarboxylase antizyme 3 (OAZ3)

Code CSB-YP016247HU
MSDS
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Source Yeast
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Code CSB-EP016247HU
MSDS
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Source E.coli
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Code CSB-EP016247HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP016247HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP016247HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
OAZ3
Uniprot No.
Alternative Names
Antizyme 3; AZ3; OAZ t; OAZ3; OAZ3_HUMAN; ODC-Az 3; Ornithine decarboxylase antizyme 3; RP11-98D18.13-004; Testicular secretory protein Li 31; TISP15
Species
Homo sapiens (Human)
Expression Region
1-187
Target Protein Sequence
MLPRCYKSIT YKEEEDLTLQ PRSCLQCSES LVGLQEGKST EQGNHDQLKE LYSAGNLTVL ATDPLLHQDP VQLDFHFRLT SQTSAHWHGL LCDRRLFLDI PYQALDQGNR ESLTATLEYV EEKTNVDSVF VNFQNDRNDR GALLRAFSYM GFEVVRPDHP ALPPLDNVIF MVYPLERDVG HLPSEPP
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells.
Gene References into Functions
  1. Mutations in the OAZ3 gene are not a common cause of male infertility. PMID: 16542438
  2. antizyme expression requires programmed, ribosomal frameshifting PMID: 10781085
Subcellular Location
Nucleus. Cytoplasm.
Protein Families
ODC antizyme family
Tissue Specificity
Testis specific.
Database Links

HGNC: 8097

OMIM: 605138

KEGG: hsa:51686

STRING: 9606.ENSP00000415904

UniGene: Hs.713789

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