Product Details

Purity

Greater than 90% as determined by SDS-PAGE.

Target Names

PNMA2

Uniprot No.

Q9UL42

Research Area

Neuroscience

Alternative Names

40 kDa neuronal protein; KIAA0883; MA2; MM2; Onconeuronal antigen Ma2; Paraneoplastic antigen Ma2; Paraneoplastic Ma antigen 2; Paraneoplastic neuronal antigen ; Paraneoplastic neuronal antigen MM2; PNMA2; PNMA2_HUMAN; Retrotransposon gag domain containing 2; RGAG2

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

2-261aa

Target Protein Sequence

ALALLEDWCRIMSVDEQKSLMVTGIPADFEEAEIQEVLQETLKSLGRYRLLGKIFRKQENANAVLLELLEDTDVSAIPSEVQGKGGVWKVIFKTPNQDTEFLERLNLFLEKEGQTVSGMFRALGQEGVSPATVPCISPELLAHLLGQAMAHAPQPLLPMRYRKLRVFSGSAVPAPEEESFEVWLEQATEIVKEWPVTEAEKKRWLAESLRGPALDLMHIVQADNPSISVEECLEAFKQVFGSLESRRTAQVRYLKTYQEEGEKVSAYVLRLETLLRRAVEKRAIPRRIADQVRLEQVMAGATLNQMLWCRLRELKDQGPPPSFLELMKVIREEEEEEASFENESIEEPEERDGYGRWNHE
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Mol. Weight

43.1kDa

Protein Length

Partial

Tag Info

N-terminal 6xHis-tagged

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Description

Recombinant Human PNMA2 Protein is encoded by PNMA2 gene — recombinant PNMA2 DNA — that has integrated foreign plasmids into the Yeast genome, the foreign DNA is replicated along with the host DNA. In addition, the expression of foreign proteins requires the use of specialized expression vectors and often necessitates the significant restructuring of the foreign coding sequence. The subsequent expression process includes small-scale expression, protein identification, large-scale expression, and protein purification. The purity of this recombinant PNMA2 is 90%+.

IPNMA2 (also known as MA2) is a gene that encodes a protein named the paraneoplastic antigen Ma2 belonging to the human PNMA family. The protein encoded by this gene is also known as 40 kDa neuronal protein, onconeuronal antigen Ma2 and paraneoplastic neuronal antigen MM2. Paraneoplastic antigens are normally expressed only in neuronal tissues. emerging evidence has implied that paraneoplastic antigen Ma2 autoantibodies can be detected in early recurrence of small intestine neuroendocrine tumors as specific blood biomarkers.

Target Background

Gene References into Functions

PNMA2 functions as antagonist of MOAP-1 and PNMA1 through heterodimeric interaction PMID: 27003254
Immunohistochemical analysis of MA2/D2-40 combined with p16(INK4A) may have a significant implication in clinical practice for better identifying the grade of cervical intraepithelial neoplasia. PMID: 21729305
Ma2 may have a role in early recurrence of small intestine neuroendocrine tumors PMID: 21209860

Subcellular Location

Nucleus, nucleolus.

Protein Families

PNMA family

Tissue Specificity

Brain-specific. In some cancer patients, specifically expressed by testicular tumor cells.

Database Links

HGNC: 9159

OMIM: 603970

KEGG: hsa:10687

STRING: 9606.ENSP00000429344

UniGene: Hs.591838

Code	CSB-YP018267HU
Abbreviation	Recombinant Human PNMA2 protein, partial
MSDS	MSDS Datasheet
Size	$368
	Order now
Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Have Questions?	Leave a Message or Start an on-line Chat

Recombinant Human Paraneoplastic antigen Ma2 (PNMA2), partial

Product Details

Related Products

Customer Reviews and Q&A

Target Background

×CloseMessage