Purity
Greater than 90% as determined by SDS-PAGE.
Research Area
Neuroscience
Alternative Names
40 kDa neuronal protein; KIAA0883; MA2; MM2; Onconeuronal antigen Ma2; Paraneoplastic antigen Ma2; Paraneoplastic Ma antigen 2; Paraneoplastic neuronal antigen ; Paraneoplastic neuronal antigen MM2; PNMA2; PNMA2_HUMAN; Retrotransposon gag domain containing 2; RGAG2
Species
Homo sapiens (Human)
Expression Region
2-261aa
Target Protein Sequence
ALALLEDWCRIMSVDEQKSLMVTGIPADFEEAEIQEVLQETLKSLGRYRLLGKIFRKQENANAVLLELLEDTDVSAIPSEVQGKGGVWKVIFKTPNQDTEFLERLNLFLEKEGQTVSGMFRALGQEGVSPATVPCISPELLAHLLGQAMAHAPQPLLPMRYRKLRVFSGSAVPAPEEESFEVWLEQATEIVKEWPVTEAEKKRWLAESLRGPALDLMHIVQADNPSISVEECLEAFKQVFGSLESRRTAQVRYLKTYQEEGEKVSAYVLRLETLLRRAVEKRAIPRRIADQVRLEQVMAGATLNQMLWCRLRELKDQGPPPSFLELMKVIREEEEEEASFENESIEEPEERDGYGRWNHE
Note: The complete sequence including tag
sequence, target protein sequence and linker sequence could be provided upon request.
Tag Info
N-terminal 6xHis-tagged
Form
Liquid or Lyophilized powder
Note: We will preferentially ship the format that
we have in stock, however, if you have any special requirement for the format, please remark your
requirement when placing the order, we will prepare according to your demand.
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the
glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer,
6% Trehalose, pH 8.0.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw
cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature
and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized
form is 12 months at -20°C/-80°C.
Lead Time
3-7 business days
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.
Description
The expression region of this recombinant Human PNMA2 KIAA0883 MA2 covers amino acids 2-361. The expected molecular weight for the PNMA2 KIAA0883 MA2 protein is calculated to be 45.1 kDa. This PNMA2 KIAA0883 MA2 protein is produced using e.coli expression system. The PNMA2 KIAA0883 MA2 coding gene included the N-terminal 6xHis tag, which simplifies the detection and purification processes of the recombinant PNMA2 KIAA0883 MA2 protein in following stages of expression and purification.
Paraneoplastic antigen Ma2 (PNMA2) is a protein associated with paraneoplastic neurological disorders (PND). Similar to PNMA1, PNMA2 is involved in autoimmune responses that target neural tissues in the presence of an underlying tumor. The immune system produces antibodies against PNMA2, contributing to the development of PNDs. These disorders often affect the nervous system, leading to a range of neurological symptoms. Research on PNMA2 primarily focuses on understanding its role in paraneoplastic syndromes, deciphering the mechanisms of the immune response against this antigen, and exploring its potential as a therapeutic target.
