Recombinant Human Peroxidasin homolog (PXDN), partial

1. PXDN might play a promoter role in the proliferation, invasion and migration of ovarian cancer (OC) cells through regulating the activation of PI3K/Akt pathway. Therefore, PXDN might be regarded as a potential target for OC therapy. PMID: 29661721
2. e showed that collagen IV crosslinks remain intact even under strongly hypoxic conditions. Our hypothesis is that during collagen IV network formation PXDN cooperates with a NOX/DUOX-independent H2O2 source that is functional also at very low ambient oxygen levels. PMID: 29573705
3. Data indicate that VPO1 plays a critical role in regulating eNOS expression and activity by structural change and de-phosphorylation. VPO1 expression was up-regulated in Ang-treated HUVECs. Knockdown of VPO1 was su ffi cient to attenuate the Ang induced decrease in eNOS expression and activity. Moreover, the e ff ect of VPO1 on eNOS was mainly achieved by HOCl formation. PMID: 28264790
4. Results show that PXDN expression decreases with TGF-beta1 treatment in cervical carcinoma cell lines, and is regulated by the EMT master transcription factor Snai1. This implicates PXDN in cancer development and processes that involve EMT. PMID: 29305973
5. Data suggest that VPO1 contributes to oxidation and retention of LDL in vessel walls, and formation foam cells, indicating VPO1 as a novel potential mediator of atherosclerosis. PMID: 27167346
6. VPO1 plays a critical role in asymmetric dimethylarginine production via H2O2-VPO1-hypochlorous acid pathways, which may contribute to endothelial dysfunction in hypertension. PMID: 27475679
7. The kinetic data unravel the substrate specificity and mechanism of halide oxidation of human peroxidasin 1. The heme enzyme is shown to follow the halogenation cycle that is induced by the rapid H2O2-mediated oxidation of the ferric enzyme to the redox intermediate compound I. Chloride cannot act as a two-electron donor of compound I, whereas thiocyanate, iodide, and bromide efficiently restore the ferric state. PMID: 28154175
8. PC processing of Pxdn is a key regulatory step that contributes to its function and, therefore, supports BM integrity and homeostasis. PMID: 27697841
9. PXDN expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
10. The catalytic domain of peroxidasin and its immunoglobulin (Ig) domains are required for efficient sulfilimine bond formation. PMID: 26178375
11. Novel mutations in PXDN cause microphthalmia and anterior segment dysgenesis PMID: 24939590
12. Despite sequence homology at the active site and biophysical properties similar to human peroxidases, the catalytic efficiency of bromide oxidation (kcat/KM(app)) of full-length hsPxd01 is rather low but increased upon truncation. PMID: 25713063
13. Peroxidasin is essential for eye development in the mouse. PMID: 24895407
14. MiR-4782-3p inhibited cell proliferation in NSCLC by targeting USP14, ZEB2 and XIAP. PMID: 24556843
15. studies demonstrate the enzymatic properties and substrate specificity of VPO1 are similar to MPO; however, significantly lower catalytic rate constants of VPO1 relative to MPO suggest the possibility of other physiologic roles for this peroxidase PMID: 22982576
16. VPO1 is likely to participate in host defense, with bactericidal activity mediated through the generation of HOCl. PMID: 22526679
17. Results from this study indicate that the 2p25.3 duplication disrupting PXDN and MYT1L is a potential autism-causing variant in the pedigree reported here and should receive further consideration as a candidate for autism PMID: 22157634
18. plays a critical role in ox-LDL-induced endothelial cell apoptosis PMID: 21820048
19. Vascular peroxidase-1 is rapidly secreted, circulates in plasma, and supports dityrosine cross-linking reactions. PMID: 21798344
20. Homozygous mutations in PXDN cause congenital cataract, corneal opacity, and developmental glaucoma. PMID: 21907015
21. peroxidasin secretion represents a previously unknown pathway in extracellular matrix formation with a potentially important role in the physiological and pathological fibrogenic response. PMID: 19590037

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HGNC: 14966

OMIM: 269400

KEGG: hsa:7837

STRING: 9606.ENSP00000252804

UniGene: Hs.332197