Recombinant Human Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

1. Data report that NOXA is a physiological substrate of autophagy. Mechanistic studies revealed that NOXA is hijacked by p62 for degradation during the autophagic process, and the three lysine residues at the C-terminus of NOXA are required for its autophagic degradation. Furthermore, autophagy can block apoptosis by eliminating NOXA in both p53-dependent and p53-independent manners. PMID: 29758299
2. Fluorizoline increased the protein levels of the pro-apoptotic B-cell lymphoma 2 family member NOXA in chronic lymphocytic leukemia cells. Furthermore, fluorizoline synergized with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax to induce apoptosis. PMID: 28619845
3. By ubiquitylating and degrading NOXA through activating CRL5, UBE2F selectively promotes lung cancer cell survival and could, therefore, serve as a novel cancer target PMID: 27591266
4. Data show that Noxa-mediated MCL-1 phosphorylation and degradation is regulated by CDK2. PMID: 27166195
5. the c-FLIP and NOXA/Mcl-1 axis participated in the synergistic effect of pemetrexed plus cisplatin in human choroidal melanoma cells PMID: 28863158
6. Noxa is involved in X-ray-induced lung injury. PMID: 27862899
7. Arsenic trioxide induces Noxa-dependent apoptosis in rhabdomyosarcoma cells and acts synergistically with antimicrotubule drugs. PMID: 27521572
8. knockdown of MCL-1 in MRT cell lines induced apoptosis and increased DOX sensitivity in malignant rhabdoid tumor cells PMID: 26680268
9. high levels of miR21 expression may induce gastric cancer migration and invasion via the downregulation of Noxa expression PMID: 26847916
10. Inhibition of SIRT1 could induce the Noxa expression in A549/DDP cells. PMID: 26903157
11. Fluorizoline bind to prohibitin, inducing mitochondrial apoptotic pathway through NOXA and BIM upregulation. PMID: 26497683
12. Noxa demethylation has a role in Bortezomib resistance in mantle cell lymphoma PMID: 25714012
13. SATB1 as a Dual Regulator of Anti-Apoptotic BCL2 and Pro-Apoptotic NOXA Genes PMID: 26422397
14. ALK-negative anaplastic large cell lymphoma is sensitive to bortezomib through Noxa upregulation and release of Bax from Bcl-2. PMID: 25975837
15. BCL2 and BCLX phosphorylation represents a priming event in mitotic cell death that is triggered by NOXA-dependent MCL1 degradation. The MCL1 decay allows in turn BIM-dependent cell death. PMID: 25922916
16. Overexpression of nonphosphorylatable Noxa resulted in enhanced mitochondria-mediated apoptosis in the infected epithelium. PMID: 25404713
17. Results reveal that oncogenic activation of MEK/ERK drives Noxa expression to promote autophagy, and suggest that Noxa has an indirect anti-apoptosis role in melanoma cells under nutrient starvation conditions. PMID: 25365078
18. Overall, these data reveal a Noxa-mediated signaling pathway that couples lysosomal membrane permeabilization with mitochondrial outer membrane permeabilization and ultimate apoptosis during oxidative stress. PMID: 23770082
19. CDK5 activity provides resistance to heat-induced apoptosis through the expression of miR-23a and subsequent suppression of NOXA synthesis PMID: 25829494
20. Mcl-1/Noxa axis is important to overcome resistance to mitochondrial apoptosis in squamous cell carcinoma. PMID: 25210795
21. Cells overexpressing HSP70 had higher levels of miR-23a, maintained these levels after heat shock and accumulated lower levels of NOXA mRNA and protein. PMID: 25429623
22. Noxa upregulation reduces the availability of Usp9x to Mcl-1, thereby promoting its ubiquitination and degradation, leading to the apoptosis of neoplastic cells. PMID: 24991768
23. Overexpression of ApoL2 did not induce cell death on its own. ApoL2 did not sensitize or protect cells from overexpression of the BH3-only proteins Bmf or Noxa. PMID: 24901046
24. Noxa recruits MCL-1 from the cytosol to the mitochondria modulating ABT-737 sensitivity in small cell lung cancer. PMID: 24525728
25. these results suggest that the C-terminal tail of Noxa regulates the stability of both Noxa and Mcl-1. PMID: 24811167
26. Mantle cell lymphoma are characterized by high constitutive NOXA gene expression but low levels of NOXA protein. PMID: 24457957
27. Parthenolide triggers extrinsic apoptosis by up-regulating TNFRSF10B and intrinsic apoptosis through increasing the expression of PMAIP1. PMID: 24387758
28. Knockdown of TRAIL and Noxa reduced FOXO3-induced apoptosis, implicating that mitochondrial destabilization amplifies TRAIL-signaling. PMID: 23828551
29. Physalin A-induced apoptosis was triggered by activation of p53-Noxa pathway. PMID: 23684722
30. CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak. PMID: 23798675
31. caspases contribute to trigger the mitochondrial apoptotic pathway by coupling Bcl-2/Bcl-xL inhibition to that of Mcl-1, via the pRb/E2F-1-dependent induction of Noxa PMID: 23429261
32. Vorinostat, is able to ablate the multicellular resistance to bortezomib by its ability to restore expression of a key pro-apoptotic Bcl-2 family member, Noxa. PMID: 23300762
33. NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1. PMID: 22361683
34. Noxa is a central determinant of hypersensitivity to cisplatin PMID: 23302226
35. Oncolytic viruses selectively induced expression of TRAIL and Noxa in prostate cancer cells, lung cancer cells, and breast cancer cells downstream of RIG-I and MAVS. PMID: 23014529
36. Novel but opposing roles for the p53 and TAp73 in the induction of Noxa and Bim and regulation of apoptosis. PMID: 22430213
37. Our results suggested that polymorphisms of NOXA and MCL1 may modify the risk of HPV16-associated oropharyngeal cancer. PMID: 22548841
38. detailed analysis of the Noxa promoter revealed that p73 and Sp1-like factors, Sp1 and KLF6, played key roles in the transcriptional control of this gene PMID: 22718761
39. these data suggest a new mechanism by which NOXA chemosensitized ovarian cancer cells to cisplatin by inducing alterations in the Bax/Smac axis. PMID: 22590594
40. show that miR-200c is a novel negative regulator of the pro-apoptotic Bcl-2 family member Noxa PMID: 22615771
41. during skin hypoxia, promotes UVB-induced apoptosis in keratinocytes PMID: 22245094
42. siRNA-mediated knockdown of Noxa resulted in cell cycle arrest following E2 treatment, indicating that Noxa expression is required for cell cycle progression in ER-positive breast cancer cells. PMID: 22216287
43. these study suggested that the four mutations lowered the stability of the p53 DBD domain and induced aggregation of structurally destabilized p53, and thus disrupted the p53-PUMA/NOXA interaction. PMID: 22446329
44. Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA. PMID: 21628457
45. Bortezomib can enhance sensitivity of NB4 cells to apoptosis induced by As(2)O(3) which may be related to up-regulation of proapoptotic protein NOXA. PMID: 21518486
46. Noxa is critical for sensitivity to cell death induced by 2-deoxyglucose. This is the first evidence of the implication of a BH3-only protein in death induced by 2-DG. PMID: 21911456
47. Noxa triggers the degradation of Mcl-1 at the mitochondria according to the exclusive location of Noxa at this compartment. PMID: 21907705
48. Noxa/Mcl-1 balance is regulated by glucose deprivation as well as by general metabolic stress PMID: 21516346
49. A pathway leading from the detection of viral RNA during modified vaccinia virus infection by the cytosolic helicase-pathway, to the up-regulation of Noxa and apoptosis via IRF3 and type I IFN signalling. PMID: 21698224
50. Noxa participates in triggering mitochondrial dysfunction in multiple apoptotic pathways through distinct mechanisms PMID: 21113147

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HGNC: 9108

OMIM: 604959

KEGG: hsa:5366

STRING: 9606.ENSP00000326119

UniGene: Hs.96