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Phorbol-12-myristate-13-acetate-induced protein 1 is a protein in humans that is encoded by PMAIP1 gene. Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
The following PMAIP1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
PMAIP1 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA969433 | PMAIP1 Antibody |
Human | ELISA,IHC |
| CSB-PA018229LA01HU | PMAIP1 Antibody |
Human | ELISA, IHC, IF |
| CSB-PA018229LB01HU | PMAIP1 Antibody, HRP conjugated |
Human | ELISA |
| CSB-PA018229LC01HU | PMAIP1 Antibody, FITC conjugated |
Human | |
| CSB-PA018229LD01HU | PMAIP1 Antibody, Biotin conjugated |
Human | ELISA |
PMAIP1 Antibodies for Mus musculus (Mouse)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA018229ZA01MO | Pmaip1 Antibody |
Mus musculus | ELISA, WB (ensure identification of antigen) |
PMAIP1 Proteins for Rattus norvegicus (Rat)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP018229RA CSB-EP018229RA CSB-BP018229RA CSB-MP018229RA CSB-EP018229RA-B |
Recombinant Rat Phorbol-12-myristate-13-acetate-induced protein 1 (Pmaip1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PMAIP1 Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP018229MO CSB-BP018229MO CSB-MP018229MO CSB-EP018229MO-B |
Recombinant Mouse Phorbol-12-myristate-13-acetate-induced protein 1 (Pmaip1) |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP018229MO | Recombinant Mouse Phorbol-12-myristate-13-acetate-induced protein 1 (Pmaip1) |
E.coli |
PMAIP1 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP018229HU CSB-EP018229HU CSB-BP018229HU CSB-MP018229HU CSB-EP018229HU-B |
Recombinant Human Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PMAIP1 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP018229DO CSB-EP018229DO CSB-BP018229DO CSB-MP018229DO CSB-EP018229DO-B |
Recombinant Dog Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Phorbol-12-myristate-13-acetate-induced protein 1 is a protein in humans that is encoded by PMAIP1 gene [1]. It is also known as Noxa [2]. PMAIP1/Noxa is a pro-apoptotic member of the Bcl-2 protein family [3]. Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of Noxa is regulated by the tumor suppressor p53, and Noxa has been shown to be involved in p53-mediated apoptosis. PMAIP1/Noxa promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria and contributes to p53/TP53-dependent apoptosis after radiation exposure. It also facilitates proteasomal degradation of MCL1. Through competition with BAK1 for binding to MCL1, PMAIP1/Noxa can displace BAK1 from its binding site on MCL1 (By similarity). Hyunhee Do et al. observed that overexpressed TFAP2C resulted in inhibition of GADD45B and PMAIP1 expressions at both the mRNA and protein levels in NSCLC cells. In addition, downregulation of GADD45B and PMAIP1 by TFAP2C promoted cell proliferation and cell motility, which are closely associated with NSCLC tumorigenesis [4].
[1] Hijikata M, Kato N, Sato T, Kagami Y, Shimotohno K (October 1990). "Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line". J Virol. 64 (10): 4632–9.
[2] Jansson AK, Emterling AM, Arbman G, Sun XF (July 2003). "Noxa in colorectal cancer: a study on DNA, mRNA and protein expression". Oncogene. 22 (30): 4675–8.
[3] Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (May 2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science. 288 (5468): 1053–1058.
[4] Hyunhee Do, Dain Kim et, al. TFAP2C increases cell proliferation by downregulating GADD45B and PMAIP1 in non-small cell lung cancer cells [J]. Biological Research volume 52, Article number: 35 (2019).
