Recombinant Human Phosphatidylinositol 4-kinase alpha (PI4KA), partial

1. Architecture of the human PI4KIIIalpha lipid kinase complex. PMID: 29229838
2. hCKalpha functions as an indispensable regulator that bridges PI4KIIIalpha and hepatitis C virus NS5A and potentiates NS5A-stimulated PI4KIIIalpha activity, which then facilitates the targeting of the ternary complex to the endoplasmic reticulum for viral replication. PMID: 28566381
3. Blockade of IQGAP1 interaction with PIPKIalpha or PI(3)K inhibited PtdIns(3,4,5)P3 generation and signalling, and selectively diminished cancer cell survival. PMID: 27870828
4. The results showed that, in contrast to the enteroviruses and the cardioviruses, foot-and-mouth disease virus replication does not require PI4KIII (PI4KIIIalpha and PI4KIIIbeta), and phosphatidylinositol 4-phosphate levels do not increase in foot-and-mouth disease virus-infected cells and phosphatidylinositol 4-phosphate is not seen at replication organelles. PMID: 27093462
5. Missense mutations in PI4KA are associated with perisylvian polymicrogyria, cerebellar hypoplasia and arthrogryposis. PMID: 25855803
6. Our results suggest a plasticity of the molecular interactions that control PI4KIIIalpha localization and functions at the plasma membrane. PMID: 25608530
7. PI4K III alpha plays a role in biosynthetic trafficking of two different classes of proteins from the ER to the Golgi complex. PMID: 25886792
8. PI4KA and GRM3 polymorphisms have potential to jointly modulate antipsychotic response PMID: 25209194
9. our results suggest a mechanism of PI4K IIalpha recruitment, regulation, and function at the membrane. PMID: 25168678
10. These results suggest that type II PtdIns 4-kinases are part of piperine-mediated anti-inflammatory signaling mechanisms PMID: 24671493
11. The N-terminal 1,152 amino acids were dispensable for hepatitis C virus replication, phosphatidylinositol 4-phosphate induction, and enzymatic function, thereby defining the minimal PI4KIIIalpha core enzyme at a size of ca. 108 kDa. PMID: 24920820
12. PI4KA mRNA could be used as a new molecular marker to improve established prognostic models for hepatocellular carcinoma. PMID: 24393405
13. Descriptive Statement The genetic interactions associated with ILVatrophy rate in this study may be mapping variants inSYNJ2andPI4KAthat interact to decrease synthesisof PIP. PMID: 24077433
14. PI4KA is essential for the maintenance of plasma membrane phosphatidylinositol 4,5-bisphosphate pools but only during strong stimulation of receptors coupled to phospholipase C activation. PMID: 24415756
15. we demonstrate that PI4KIIIalpha activity affects the NS5A phosphorylation status. PMID: 23675303
16. Cell culture studies with Phosphatidylinositol-4-kinase IIIalpha inhibitors demonstrated that the kinase activity was essential for hepatitis C virus RNA replication. PMID: 22896614
17. Phosphatidylinositol 4-kinase IIalpha is palmitoylated by Golgi-localized palmitoyltransferases in cholesterol-dependent manner PMID: 22535966
18. PI4KA is necessary for the local enrichment of PI 4-phosphate at the hepatitis c virus membranous web. PMID: 22022594
19. These results suggest that hepatitis C virus NS5A modulation of PI4KA-dependent phosphatidylinositol 4-phosphate production influences replication complex formation. PMID: 21697487
20. confirmed the high copy number of PI4KIIIalpha transcript in K562 cells along with several genes located in the same region in Chr22, including two pseudogenes that cover most exons coding for isoform 1, consistent with chromosome amplification PMID: 21601653
21. Study identify the molecular chaperone Hsp90 as a binding partner of PI4KIIbeta, but not of PI4KIIalpha. PMID: 21330372
22. PI4KIIIalpha is an essential host factor that supports HCV proliferation and therefore PI4KIIIalpha may be a legitimate target for anti-HCV therapy. PMID: 21297162
23. This analysis suggests that the direct activation of a lipid kinase PI4KA by hepatitis C virus NS5A contributes critically to the integrity of the membranous viral replication complex. PMID: 21238945
24. No strong association between PIK4CA and psychosis in people with 22q11.2 deletion syndrome PMID: 20052689
25. Data suggest that Rab1 contributes to the specificity and timing of GBF1 recruitment by activating PI4KIIIalpha, and that the PtdIns(4)P produced then allows GBF1 to bind to Golgi membranes and activate Arf1. PMID: 20530568
26. parallel activation by extracellular calcium-sensing receptor PMID: 11907035
27. PI4KIIIbeta (PIK4CB) and PI4KIIalpha (PIK4CA) localize to discrete subcompartments of the Golgi complex in Madin-Darby canine kidney (MDCK) cells. PMID: 15634669
28. nuclear phosphatidylinositol 4-phosphate, and consequently, synthesis of polyphosphoinositides are required for a correct nuclear function PMID: 16606619
29. These experiments suggest the participation of PI4K230 in a DNase and RNase sensitive complex with a unique localization and function in the nucleolus. PMID: 17131383
30. PI4KIIalpha or PI4KIIbeta knockdown, but not type III PI4Kbeta knockdown, inhibits Listeria internalization. PMID: 17555516
31. The PIK4CA gene is located in the chromosome 22q11 deletion syndrome region, which is of particular interest because it has been implicated in schizophrenia. PMID: 17893707
32. These results indicate that a small fraction of the cellular PI4K activity is sufficient to maintain plasma membrane phosphoinositide pools. PMID: 18077555
33. The present study suggests that the PIK4CA gene does not play a significant role in the vulnerability to METH use disorder in the Japanese population. PMID: 18521859
34. The putative bipartite nuclear localization signal(NLS) itself is a nucleolar targeting signal, and for nuclear import PI4K230 requires a larger sequence around it or, alternatively, the monopartite NLS. PMID: 18585705
35. Failure to confirm the association between the PIK4CA gene and schizophrenia in a Japanese population is reported. PMID: 18615484
36. Association of the PIK4CA schizophrenia-susceptibility gene in adults with the 22q11.2 deletion syndrome is reported. PMID: 18646052
37. the PI4KA gene was shown to be essential for the replication of all HCV genotypes tested PMID: 19304308
38. genetic or pharmacological modulation of PI4KA and PI4KB inhibits multiple genotypes of HCV PMID: 19605471
39. our library screening completed data on the clathrin-mediated endocytosis-dependant entry route of HCV and identified 2 kinases, PI4KIIIalpha and beta, as relevant potential therapeutic targets. PMID: 19608626

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HGNC: 8983

OMIM: 600286

KEGG: hsa:5297

STRING: 9606.ENSP00000458238

UniGene: Hs.529438