Recombinant Human Phosphatidylinositol 4-kinase beta (PI4KB), partial

1. PI4KIIIbeta interaction with the VHS domain of GGA2 affected PI4KIIIbeta localization. PMID: 28289207
2. several disordered regions of PI4KB become protected from proteolytical degradation upon 14-3-3 binding. PMID: 28864297
3. esults show that Aichi virus 3A protein activates the lipid kinase activity of PI4KIIIb,which activation is sensitized by the protein ACBD3. The interfaces between PI4KIIIbeta-ACBD3 and ACBD3-3A were mapped with hydrogen-deuterium exchange mass spectrometry. PMID: 27989622
4. Data show that ACBD3 can recruit PI4KB to model membranes as well as redirect PI4KB to cellular membranes where it is not naturally found. Also, results show that ACBD3 regulates the enzymatic activity of PI4KB kinase through membrane recruitment rather than allostery. PMID: 27009356
5. Analysis reveals novel aspects of the PI4KIIIb-Rab11 complex and determines binding and catalytic sites of the kinase. PMID: 26756197
6. PI4KIIIbeta likely plays a role in breast oncogenesis and that cooperation between Rab11a and PI4KIIIbeta represents a novel Akt activation pathway. PMID: 24962317
7. Although human rhinovirus 3A protein was previously shown to interact with ACBD3, these data suggest that PI4KIIIbeta recruitment occurred independently of both GBF1 and ACBD3. PMID: 25410869
8. Authors found that NS5A and PI4KB competed for association of acyl-coenzyme A binding domain containing protein 3 (ACBD3), which inhibited hepatitis C virus replication. PMID: 24792752
9. Host ACBD3, PI4KIIIBETA and Aichi virus proteins complexes enhances phosphatidylinositol 4-phosphate synthesis and is critical for viral replication. PMID: 24672044
10. these data provide a mechanism for how PI4KIIIbeta coordinates Rab11 and its effectors on PI4P-enriched membranes and also provide strategies for the design of specific inhibitors that could potentially target plasmodial PI4KIIIbeta to combat malaria. PMID: 24876499
11. The lipid kinase PI4KIIIbeta preserves lysosomal identity. PMID: 23258225
12. During authentic HCV infection, PI4P plays an integral role in virus replication; the vesicular transport proteins ARF1 and GBF1 colocalized with PI4KIIIbeta and were both required for HCV replication. PMID: 22359663
13. The 3A protein of picornaviruses utilizes the golgi adaptor protein ACBD3 to recruit PI4KIIIbeta. PMID: 22258260
14. Phosphatidylinositol 4-kinase IIIbeta is required for severe acute respiratory syndrome coronavirus spike-mediated cell entry. PMID: 22253445
15. results indicate that a viral protein/ACBD3/PI4KB complex is formed to synthesize PI4P at the AiV RNA replication sites and plays an essential role in viral RNA replication PMID: 22124328
16. Our data establish PtdIns(4,5)P(2) as a direct activator of TRPV6 and demonstrate that intracellular ATP regulates the channel indirectly as a substrate for type III PI4Ks PMID: 21810903
17. The PI4KIIIbeta likely plays an important role in mammary neoplasia and acinar development. PMID: 21851817
18. Knockdown of PI4KIIalpha does not inhibit EGF-stimulated Akt phosphorylation. PMID: 21218173
19. Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments PMID: 11923287
20. determination that the enzyme is primarily cytosolic, and it associates peripherally with plasma membranes, endoplasmic reticulum, and the Golgi PMID: 12324459
21. PI 4-kinase beta is a key enzyme in the control of spingomyelin synthesis by controlling the flow of ceramide from the ER to the Golgi compartment PMID: 17003043
22. there is a physical and functional relationship between eEF1A2 and PI4KIIIbeta PMID: 17088255
23. Work suggests an important role for both eEF1A2 and PI4KIIIbeta in the control of PI(4,5)P(2) signaling and actin remodeling. PMID: 18474610

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HGNC: 8984

OMIM: 602758

KEGG: hsa:5298

STRING: 9606.ENSP00000271657

UniGene: Hs.632465