Recombinant Human Prostacyclin synthase (PTGIS), partial

1. In examining the tumor suppressor PTGIS as a potential biomarker for treatment with either 5-Aza-dC or TSA, 5-Aza-dC effectively stabilized cell cycling, restricted genetic instability and derepressed PTGIS expression PMID: 26130461
2. Based on the predicted crystal structure of CYP8A1( *)5 using the Molecular Operating Environment platform, the distance from CYP8A1 Cys441 to the heme was altered with a significantly changed binding free energy for the mutant protein. PMID: 25623425
3. results indicate that PGIS expression was associated with radiotherapy efficiency PMID: 25256272
4. Type-2 diabetes is associated with higher COX-2 expression, but lower eNOS and PGIS expression in subcutaneous arteries. PMID: 24225501
5. In a case-control study unaffected carriers of a BMPR2 mutation, linked to pulmonary artery hypertension (PAH), were most often found to have prostacyclin synthase promoter sequence variants, which were thought to protect against PAH. PMID: 24605778
6. These findings suggest that PGIS is induced by hypoxia and regulates the expression of VEGF in fibroblasts. PMID: 23807031
7. High PTGIS expression is associated with colorectal cancer hepatic metastasis. PMID: 22219064
8. The CC genotype of C1117A polymorphism is associated with higher risk of LM-CAD PMID: 22072641
9. Overexpression of PTGIS is associated with liver metastasis in colon cancer. PMID: 22109564
10. diabetes preferentially increases PGIS nitration that is associated with excessive vascular inflammation in atherosclerotic carotid arteries from patients with type 2 diabetes PMID: 20348234
11. Review: PGI2 function depends on the different alleles of the PTGIS gene and that they may influence the risk of cardiovascular disease. PMID: 20357747
12. PGIS overexpression apparently protects insulin-producing cells against cytokine toxicity via suppression of endoplasmic reticulum and mitochondrial stress-mediated cell death pathways PMID: 20159982
13. MI is associated with the CC genotype of rs5629 in the human CYP8A1 gene. The A-C-T haplotype appears to be a useful genetic marker and the C-T-T haplotype might be a protective factor of MI in Chinese people. PMID: 19147528
14. Association study between a novel single nucleotide polymorphism of the promoter region of the prostacyclin synthase gene and essential hypertension. PMID: 11924728
15. NMR and circular dichroism solution structure of microsomal PGIS PMID: 12193162
16. the fallopian tube expresses both COX isoforms and PGIS PMID: 12213900
17. the PGIS gene has a splicing mutation in familial hypertension PMID: 12372404
18. Cyclic mechanical stretch augmented prostacyclin synthase promoter activity, via activation of activator protein-1 site, and prostacyclin synthase mRNA and protein expression in cultured human myometrial cells PMID: 12414894
19. gestational age decrease in the inhibitory prostaglandin I2 synthase is consistent with lessening of its influence in myometrium at the time of labor PMID: 12414902
20. effect of overexpression of this enzyme transfected into vascular smooth muscle cells in rats PMID: 12664597
21. residue(s) within helix F/G loop of PGIS may be involved in forming the substrate access channel and located in a position that influences the membrane-bound PGIS catalytic function PMID: 12741817
22. splicing mutation found in hypertension PMID: 12751759
23. We successfully identified haplotypes of the PGIS gene, and these haplotypes were not associated with essential hypertension. PMID: 12924623
24. results suggest specific VNTR polymorphism in the 5'-upstream promoter region of the PGIS gene regulated prostacyclin production, but did not seem to be associated with development of CTEPH (chronic thromboembolic pulmonary hypertension) PMID: 15182267
25. Epigenetic inactivation of the PTGIS gene is a recurrent alteration in colorectal carcinogenesis PMID: 16007128
26. The two major genetic loci Pgis1 and Pgis2 of murine spondylitis are homologous to chromosome regions in human genome, which control ankylosing spondylitis in human patients. PMID: 16081819
27. PGIS has a typical low-spin heme with a hydrophobic active site. PMID: 16406803
28. Dengue virus could promote the expression of PGIS mRNA in HUVEC and increase the level of PGI(2), which may increase the vascular permeability. PMID: 17210107
29. In vitro shear stress can promote PGI(2 )secretion by human endothelial progenitor cells. PMID: 17221326
30. Adenovirus PGIS gene transfer reduced PPAR delta expression and inhibited neointimal formation after balloon injury in accordance with the reduction in the phosphorylation of p38 MAPK PMID: 17303142
31. PGIS promoter haplotype can play an important role in the predisposition for lung cancer and CpG methylation provides an epigenetic mechanism for the down-regulated PGIS expression. PMID: 17374734
32. An intramuscular injection of AAV-PGIS prevents monocrotaline-pulmonary arterial hypertension in rats and provides a new therapeutic alternative for preventing pulmonary arterial hypertension in humans. PMID: 17635855
33. These studies have provided the structural information for the interaction of the PGIS with its substrate mimic. PMID: 18081314
34. Populations with both COX-2 -765GG and PGIS CC genotypes were more at risk for myocardial infarction. PMID: 19040046
35. PTGIS genetic variation is associated with incident myocardial infarction. Carriers of rs20417C allele may derive greater benefits from aspirin use. PMID: 19046748
36. The CC genotype and C allele of the prostacyclin synthase gene might be a risk factor of MI in Uigur population in Xinjiang. PMID: 19065539
37. Characterization of the recombinant PGIS intermediates is reported in reactions with other peroxides, peracetic acid, and iodosylbenzene, providing a mechanistic model of a peroxidase reaction catalyzed by the class III cytochromes P450. PMID: 19187034
38. rs237484 is in proximity to the potassium voltage gate channel gene (KCNB1) and close to the prostaglandin I2 (prostacyclin) synthase gene (PTGIS). PMID: 19265782
39. The CC genotype of CYP8A1 is associated with myocardial infarction(MI), respectively. PMID: 19327107
40. In the Uigur population CC genotype of rs5629 and the C-T-T haplotype of prostacyclin synthase gene are associated with myocardial infarction but the A-C-T haplotype of prostacyclin synthase gene might be a protective factor. PMID: 19719985

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HGNC: 9603

OMIM: 145500

KEGG: hsa:5740

STRING: 9606.ENSP00000244043

UniGene: Hs.302085