Recombinant Human Protein BEX2 (BEX2)

Code CSB-YP883628HU
MSDS
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Source Yeast
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Code CSB-EP883628HU
MSDS
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Source E.coli
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Code CSB-EP883628HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP883628HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP883628HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
BEX2
Uniprot No.
Alternative Names
BEX2Protein BEX2; Brain-expressed X-linked protein 2; hBex2
Species
Homo sapiens (Human)
Expression Region
1-128
Target Protein Sequence
MESKEERALN NLIVENVNQE NDEKDEKEQV ANKGEPLALP LNVSEYCVPR GNRRRFRVRQ PILQYRWDIM HRLGEPQARM REENMERIGE EVRQLMEKLR EKQLSHSLRA VSTDPPHHDH HDEFCLMP
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity.
Gene References into Functions
  1. The study reveals that BEX2 promotes colorectal cancer cell proliferation via the JNK/c-Jun pathway, suggesting BEX2 as a potential candidate target for the treatment of CRC. PMID: 28367093
  2. Bex2 affects the invasion and migration ability of glioma cells by regulating beta-catenin PMID: 25490384
  3. Bex2 overexpression promoted cell migration and invasion in glioma cell lines. PMID: 22907646
  4. Bex2 may be an important player during the development of glioma PMID: 23022184
  5. Both BEX2 and INI1/hSNF5 mainly localized in cell nucleus. PMID: 22698742
  6. BEX2 overexpression was associated with breast cancer. PMID: 21384344
  7. BEX2 has a functional interplay with c-Jun and p65/RelA in breast cancer. PMID: 20482821
  8. These results suggest that the conspicuous expression of the tumor suppressor genes BEX2, IGSF4 and TIMP3 in MLLmu acute myeloid leukemias cell lines is the consequence of altered epigenetic properties of MLL fusion proteins. PMID: 19835597
  9. hBex2 may act as a specific regulator during embryonic development by modulating the transcriptional activity of a novel E-box sequence-binding complex that contains hBex2, LMO2, NSCL2 and LDB1. PMID: 16314316
  10. Correlation between BEX2 expression and mixed lineage leukemia chromosomal aberrations are shown in the cell lines. PMID: 17251904
  11. a NGF/BEX2/NF-kappaB pathway is involved in regulating apoptosis in breast cancer cells and in modulating response to tamoxifen in primary tumors PMID: 17638883
  12. BEX2 is implicated in oligodendroglioma biology. PMID: 19412433

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Subcellular Location
Cytoplasm. Nucleus.
Protein Families
BEX family
Tissue Specificity
Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Widely expressed in breast cancer cell lines.
Database Links

HGNC: 30933

OMIM: 300691

KEGG: hsa:84707

STRING: 9606.ENSP00000442521

UniGene: Hs.398989

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