Recombinant Human Protein L-Myc (MYCL), partial

Code CSB-EP015274HU1
Abbreviation Recombinant Human MYCL protein, partial
MSDS
Size $256
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Product Details

Purity
Greater than 85% as determined by SDS-PAGE.
Activity
Not Test
Target Names
MYCL
Uniprot No.
Research Area
Others
Alternative Names
Class E basic helix-loop-helix protein 38;bHLHe38;Protein L-Myc-1;V-myc myelocytomatosis viral oncogene homolog
Species
Homo sapiens (Human)
Source
E.coli
Expression Region
242-364aa
Target Protein Sequence
AAGEKEDEEDEEIVSPPPVESEAAQSCHPKPVSSDTEDVTKRKNHNFLERKRRNDLRSRFLALRDQVPTLASCSKAPKVVILSKALEYLQALVGAEKRMATEKRQLRCRQQQLQKRIAYLTGY
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
Mol. Weight
29.4 kDa
Protein Length
Partial
Tag Info
N-terminal 6xHis-KSI-tagged
Form
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Gene References into Functions
  1. These results suggest that Mycl1 expression might be useful as a biomarker to predict prognosis and is a promising therapeutic target for patients with gastric cancer. PMID: 25528583
  2. Several tagging SNPs and haplotypes in TRIT1, MYCL1 and MFSD2A region are significantly associated with risk and clinicopathological features of gastric cancer in a Chinese population. PMID: 23349019
  3. The polymorphism of H-ras and L-myc genes is not related to colorectal cancer risk, but there is a synergy between H-ras and L-myc polymorphisms in the development of rectal cancer. PMID: 22490849
  4. MYCL1 is the target of hsa-miR-1827. A rs3134615 G>T SNP in the 3'-UTR altered regulation of MYCL1 expression. This SNP was associated with increased susceptibility to SCLC, possibly resulting from attenuated interaction with the miRNA hsa-miR-1827. PMID: 21676885
  5. The results demonstrate that MYCL1 rs3134613 is associated with susceptibility to diffuse-type gastric cancer and with differentiation of gastric cancer. PMID: 20874233
  6. L-myc polymorphism may affect the induction of lung cancer by smoking PMID: 11802801
  7. L-myc proto oncogene RFLP is associated with lung adenocarcinoma PMID: 11836605
  8. Allelic deletions of L-myc in urine from bladder cancer patients PMID: 11956626
  9. MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmoary fibrosis PMID: 12169206
  10. Colorectal tumor patients whose tumors exhibited loss of heterozygosity at MYCL1 at chromosome 1p34 were likely to have a poor prognosis. PMID: 15014029
  11. polymorphisms in the MYCL1 LD region affect lung cancer survival but that the functional element(s) may show population-specific patterns PMID: 17145094
  12. L-myc gene polymorphism may have a role in risk of thyroid cancer PMID: 18566574
  13. The L-myc gene polymorphism may help detect and prevent HNNMSC and LLC in susceptible individuals. It may also contribute to estimation of tumor behavior in patients with HNNMSC. PMID: 18645122
  14. L-Myc may have a role in Merkel cell carcinoma pathogenesis PMID: 19020549

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Subcellular Location
Nucleus.
Database Links

HGNC: 7555

OMIM: 164850

KEGG: hsa:4610

STRING: 9606.ENSP00000380494

UniGene: Hs.437922

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