Recombinant Human Protein UXT (UXT)

1. UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells. PMID: 28106301
2. EZH1, SUZ12 and UXT work synergistically to regulate pathway activation in the nucleus. PMID: 27127229
3. we describe the identification of UXT as a novel MDMX-interacting protein PMID: 25974965
4. UXT is a binding protein of PIAS2, and interaction between PIAS2 and UXT may be important for the transcriptional activation of AR. PMID: 25434787
5. Art27 interacts with GATA4, FOG2 and NKX2.5 and is a novel co-repressor of cardiac genes. PMID: 24743694
6. Knockdown of UXT expression in Treg cells results in a less-suppressive phenotype. PMID: 24136450
7. Data found that the UXT isoforms elicit dual opposing regulatory effects on SARM-induced apoptosis. PMID: 24021647
8. Epstein-Barr virus BGLF4 kinase downregulates NF-kappaB transactivation through phosphorylation of coactivator UXT PMID: 22933289
9. Loss of ART-27 enhances expression of many androgen-regulated genes, suggesting that ART-27 inhibits gene expression, and nuclear ART-27 expression was lost in the majority of AR-positive recurrent prostate cancers. PMID: 19318562
10. UXT-V1 represents a novel integral component of the MAVS signalosome on mitochondria, mediating the innate antiviral signal transduction. PMID: 22131337
11. these results suggest that Als2 is a binding partner of Uxt and Als2/Uxt interaction could be important for the activation of Nf-kappaB pathway. PMID: 21907703
12. Data show that while Art-27 can bind AR directly, URI is bound to chromatin prior to hormone-dependent recruitment of AR, suggesting a role for URI in modulating AR recruitment to target genes. PMID: 21730289
13. Ubiquitously expressed transcript, UXT-V1, is a novel regulator of TNF-induced apoptosis. It protects cells against TNF-induced apoptosis through modulating complex II formation. PMID: 21307340
14. decreased levels of ART-27 protein in prostate cancer tissue may occur as a result of de-differentiation, and indicate that ART-27 is likely to regulate a subset of AR-responsive genes important to prostate growth suppression and differentiation. PMID: 14711828
15. UXT is a component of centrosome and is essential for cell viability and may facilitate transformation by corrupting regulated centrosome functions. PMID: 16221885
16. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria. PMID: 17554592
17. UXT is a novel and essential cofactor in the NF-kappa B transcriptional enhanceosome. PMID: 17620405
18. UXT suppresses cell transformation and might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like ecotropic viral integration site 1 PMID: 17635584
19. propose a transcriptional regulatory circuit for the developmental expression of ART-27 that includes repression by chromatin modification through a trichostatin A-sensitive factor and activation upon growth factor stimulation via CREB PMID: 17761951
20. Is part of an RNA polymerase II-associated complex with possible chaperone activity. PMID: 19450687
21. UXT was identified in a screen for proteins that interact with the Androgen Receptor N-terminal activation domain. We termed the protein Androgen Receptor Trapped clone 27 (ART-27). ART-27 appears to function as a transcriptional coactivator protein. PMID: 11854421

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HGNC: 12641

OMIM: 300234

KEGG: hsa:8409

STRING: 9606.ENSP00000337393

UniGene: Hs.172791