Recombinant Human Protein-methionine sulfoxide oxidase MICAL2(MICAL2),partial

In Stock
Code CSB-YP013808HU
Product Type Recombinant Protein
Size US$2010Purchase it in Cusabio online store
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Uniprot No. O94851
Lead Time 3-7 business days
Relevance Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Storage Buffer Tris-based buffer,50% glycerol
Alias Molecule interacting with CasL protein 2 ;MICAL-2
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVNVEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNHYGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQTTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEH
Research Area Cell Biology
Source Yeast
Gene Names MICAL2
Protein Names Recommended name: Protein-methionine sulfoxide oxidase MICAL2 EC= 1.14.13.- Alternative name(s): Molecule interacting with CasL protein 2 Short name= MICAL-2
Expression Region 1-495aa
Tag Info N-terminal 6xHis-tagged
Mol. Weight 58.5kDa
Protein Description Partial
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum
Subcellular Location Nucleus
Protein Families Mical family
Database Links

HGNC: 24693

OMIM: 608881

KEGG: hsa:9645

STRING: 9606.ENSP00000256194

UniGene: Hs.501928

Q&A and Customer Reviews

Q&A
Q:

I am interested in CSB-YP013808HU. I need to know if you have any information about the folding in the buffer you have used to purify and if it is possible to obtain it without the tag.
Is it the protein lyophilized?

A:
Thanks for your inquiry.
We've expressed this protein derived from Yeast, and the buffer is 20 mM Tris-HCl, 0.5M NaCl, pH 8.0,50% glycerol
We could provide the lyophilization service for free, lead time will be extended 3 business days.
Customer Reviews

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