Recombinant Human Protocadherin Fat 1 (FAT1), partial

1. Fat1 functional loss results in YAP1 activation and is associated with human malignancies. PMID: 29985391
2. Study showed that FAT1 exhibits a high frequency of mutations and a downregulated expression in esophageal squamous cell carcinoma (ESCC) leading to cell migration and invasion by affecting the cellular mechanical properties of ESCC cells. PMID: 29565465
3. FAT1 has a novel regulatory effect on EMT/stemness markers both via or independent of HIF-1alpha. The functional relevance of this study was corroborated by significant reduction in the number of soft-agar colonies formed in hypoxic-siFAT1 treated U87MG cells. PMID: 28994107
4. FAT1 mutational status is a strong independent prognostic factor in patients with HPV-negative head and neck squamous cell carcinoma; FAT1 mutation was significantly associated with better overall survival PMID: 26876381
5. Disruption of MAPK/ERK pathway by FAT1 contributes the epithelial mesenchymal transformation in esophageal squamous cell carcinomas. PMID: 28366557
6. Loss of function mutations in FAT1 and CASP8 prevent cell adhesion and promote cell migration and proliferation in oral squamous cell carcinoma cell lines. PMID: 27693639
7. We identified recurrent mutations in the novel penile cancer tumor suppressor genes CSN1(GPS1) and FAT1 PMID: 27325650
8. FAT1 and mAb198.3 may offer new therapeutic opportunities for CRC. PMID: 27328312
9. Data show that the two N-terminal SH3 domains of SH3 domain containing ring finger 1 (SH3RF1) protein interact with FAT1 protein. PMID: 28129444
10. At the molecular level, under hypoxia the FAT1 depletion-associated reduction in HIF1alpha was due to compromised EGFR-Akt signaling as well as increased VHL-dependent proteasomal degradation of HIF1alpha. PMID: 27536856
11. Low FAT1 expression was associated with poor prognosis in children with medulloblastoma. Furthermore, FAT1 may act on Wnt signaling pathway to exert its antitumor effect PMID: 27834469
12. Recessive mutations in FAT1 cause a distinct renal disease entity in four families with a combination of steroid-resistance nephrotic syndrome, tubular ectasia, haematuria and facultative neurological involvement. PMID: 26905694
13. that loss of FAT1 and beta-catenin are associated with breast cancer progression, aggressive behavior, and poor prognosis PMID: 26721716
14. FAT1 protein acts upstream of Hippo signalling through TAZ protein to regulate neuronal differentiation. PMID: 26104008
15. Fat1 is released from pancreatic cancer cells in its soluble form by ADAM10 mediated ectodomain shedding PMID: 24625754
16. our data suggest that defective FAT1 is associated with an FSHD-like phenotype. PMID: 25615407
17. FAT1 is expressed at lower levels in muscles that are affected at early stages of facioscapulohumeral muscular dystrophy progression. PMID: 26018399
18. Analysis revealed an aberrant expression of FAT1 predominantly in mature BCP-ALL and thymic T-ALL and a high rate of FAT1 mutations. PMID: 24972153
19. FJX1 does not influence the levels of FAT1 ectodomain phosphorylation. PMID: 25150169
20. FAT1 expression in HCC is regulated via promotor methylation. PMID: 24590895
21. Fat1 may therefore provide a new marker of MRD for patients with ALL lacking known genomic aberrations or within a multiplex approach to MRD detection. PMID: 23433465
22. This work establishes S1-processing as a clear functional prerequisite for ectodomain shedding of FAT1 with general implications for the shedding of other transmembrane receptors. PMID: 24560745
23. frequency of FAT1-mutated cases was significantly higher in drug resistant chronic lymphocytic leukemia than in unselected chronic lymphocytic leukemia PMID: 24550227
24. There is a mechanism to regulate death receptor-mediated apoptosis via an interaction between FAT1 and procaspase-8. PMID: 24442637
25. this study identifies a novel signaling mechanism mediated by FAT1 in regulating the activity of PDCD4 in gliomas. PMID: 22986533
26. Our study identifies FAT1 as a critical determinant of muscle form, misregulation of which associates with facioscapulohumeral dystrophy . PMID: 23785297
27. Taken together, these data strongly point to FAT1 as a tumor suppressor gene driving loss of chromosome 4q35, a prevalent region of deletion in cancer PMID: 23354438
28. FAT1 suppression in activated hepatic stellate cells caused a downregulation of NFkappaB activity PMID: 22959770
29. Lipid accumulation in myotubes derived from obese type 2 diabetic patients arises from abnormal FAT/CD36 cycling. PMID: 22194967
30. data presented demonstrate that Fat1 expression in preB-ALL has a role in the emergence of relapse and could provide a suitable therapeutic target in high-risk preB-ALL PMID: 22116550
31. In vitro localization studies of FAT1 showed that melanoma cells display high levels of cytosolic FAT1 protein, whereas keratinocytes, despite comparable FAT1 expression levels, exhibited mainly cell-cell junctional staining PMID: 21680732
32. FAT1 may be involved in the migration and invasion mechanisms of oral squamous cell carcinoma cells PMID: 21617878
33. Processing of FAT1 and the translocation of its cytoplasmic domain to the nucleus were studied. PMID: 15922730
34. A cadherin gene, FAT, confers susceptibility to bipolar disorder in four independent cohorts. In mice, Fat was shown to be significantly downregulated and Catnb and Enah were significantly upregulated in response to therapeutic doses of lithium. PMID: 16402135
35. Fat1 exhibit co-localisation with Homer-3 in cellular protrusions and at the plasma membrane of HeLa cells PMID: 16979624
36. results identify mutations in FAT as an important factor in the development of oral cancer and indicate the importance of FATs function in some squamous cell carcinomas PMID: 17325662
37. FAT1(WT) is up-regulated in migration, induces cellular process formation when overexpressed, and is necessary for efficient wound healing PMID: 17500054
38. This study did not support the two FAT polymorphism in the affectve disorder. PMID: 17895925
39. The results of this study supports an involvement of variation at the FAT gene in the etiology of BPAD. PMID: 17938632
40. Results point to a role of the FAT in astrocytic tumorigenesis and demonstrate the use of RAPD analysis in identifying specific alterations in astrocytic tumors. PMID: 19126244

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HGNC: 3595

OMIM: 600976

KEGG: hsa:2195

STRING: 9606.ENSP00000406229

UniGene: Hs.481371