Recombinant Human Rap guanine nucleotide exchange factor 2(RAPGEF2) ,partial

Product Type Recombinant Protein
Uniprot No. Q9Y4G8
Abbreviation RAPGEF2
Species Homo sapiens (Human)
Gene Names RAPGEF2
Protein Names Recommended name: Rap guanine nucleotide exchange factor 2 Alternative name(s): Neural RAP guanine nucleotide exchange protein Short name= nRap GEP PDZ domain-containing guanine nucleotide exchange factor 1 Short name= PDZ-GEF1
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
HGNC 16854
RGD 1306434
MGI 2659071
Function Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP
Subcellular Location Cytoplasm, Cytoplasm, perinuclear region, Cell membrane, Late endosome, Cell junction
Protein Families RAPGEF2 family
Tissue Specificity Expressed in primary neuronal and endocrine cells (at protein level). Highest expression levels in brain. Lower expression levels in heart, kidney, lung, placenta and blood leukocytes.
Database Links

HGNC: 16854

OMIM: 609530

KEGG: hsa:9693

STRING: 9606.ENSP00000264431

UniGene: Hs.744884

Pathway MAPK signaling pathway
Rap1 signaling pathway

Product Details for Different Expression Systems

Product Name Recombinant Human Rap guanine nucleotide exchange factor 2(RAPGEF2) ,partial,Yeast
Code CSB-YP897493HU
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Human Rap guanine nucleotide exchange factor 2(RAPGEF2) ,partial,E.coli
Code CSB-EP897493HU
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Human Rap guanine nucleotide exchange factor 2(RAPGEF2) ,partial,Baculovirus
Code CSB-BP897493HU
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Human Rap guanine nucleotide exchange factor 2(RAPGEF2) ,partial,Mammalian cell
Code CSB-MP897493HU
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Still Have Questions? Leave a Message or Start an on-line Chat

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