Recombinant Human Receptor-type tyrosine-protein phosphatase delta (PTPRD), partial

1. PTPRD rs35929428 might play a role in hepatic lipid accumulation and fibrosis, followed by the development of NAFLD. PMID: 28497593
2. Results show the existence of a perturbed PTPRD-STAT3 axis potentially driving malignant progression of Hepatitis C virus-associated liver disease. PMID: 28159835
3. Presynaptic differentiation induced by protein tyrosine phosphatase receptor type D (PTPdelta)-leucine rich repeat and fibronectin type III domain containing 5 (SALM5) requires the dimeric property of SALM5. PMID: 29348429
4. In the 2:2 heterotetrameric SALM5/PTPdelta complex, a SALM5 dimer bridges two separate PTPdelta molecules. PMID: 29348579
5. our study suggested that PTPRD loci are candidate susceptibility regions that have some marker SNPs for GDM in Han Chinese PMID: 27738328
6. We investigated the modification of air pollution and diabetes association by a genetic risk score covering 63 T2D genes. Five single variants near GRB14, UBE2E2, PTPRD, VPS26A and KCNQ1 showed nominally significant interactions with PM10 (P<0.05). Our results suggest that genetic risk for T2D may modify susceptibility to air pollution through alterations in insulin sensitivity PMID: 27281273
7. Mutation in PTPRD gene is associated with nodal marginal zone lymphoma. PMID: 27335277
8. Low PTPRD expression is associated with Head and Neck Squamous Cell Carcinoma. PMID: 27501229
9. The data provide evidence of the high incidence of PTPRD inactivation in laryngeal squamous cell carcinoma, suggesting that deletions and loss-of-function mutations are responsible for PTPRD loss only in a fraction of cases, whereas DNA methylation is the dominating mechanism of PTPRD inactivation. PMID: 28345455
10. PTPRD polymorphisms might modulate antipsychotic-induced weight gain. PMID: 26656879
11. overexpression in acute myeloid leukaemia cells inhibited cell proliferation and clonogenicity as well as inducing apoptosis PMID: 26607758
12. PTPRD was identified as a novel locus potentially associated with blood pressure response to atenolol and resistant hypertension in multiple ethnic groups. PMID: 26425837
13. PTPRD mutation, but not methylation or copy number loss, may serve as a predictive biomarker of sensitivity to STAT3 inhibitors in HNSCC. PMID: 26267899
14. Study shows for the first time that DNMT1 caused PTPRD DNA hypermethylation and induced insulin signaling silencing in T2D patients. PMID: 26079428
15. PTPRD is homozygously deleted and epigenetically downregulated in hepatocellular carcinomas (HCCs). PMID: 25831062
16. This study demonstrated that the copy number variations of PTPRD relate to opioid dependence. PMID: 25345593
17. Silencing PTPRD expression by siRNA treatment significantly enhanced cell proliferation compared with mock siRNA treatment. PMID: 25412184
18. we report desmoplakin, a desmosomal protein that is implicated in cell-cell adhesion, as a novel PTPRD substrate. PMID: 25113440
19. Ptprd is a tumor suppressor that can promote tumorigenesis in concert with Cdkn2a loss. PMID: 25138050
20. The absence of MIM led to PTPdelta-mediated activation of SRC. PMID: 25287652
21. We reveal that PTPRD is a bona fide tumor suppressor, pinpoint PTPRD loss as a cause of aberrant STAT3 activation in gliomas, and establish PTPRD loss, in the setting of CDKN2A/p16(INK4A) deletion, as a driver of glioma progression. PMID: 24843164
22. Data suggest that PTPRD germline mutations may play a role in the development of Ewing sarcoma. PMID: 23800680
23. Data indicate that expression of several predicted chimeric genes and genes with disrupted exon structure including ALK, NBAS, FHIT, PTPRD and ODZ4 in neuroblastoma. PMID: 23991058
24. Loss of PTPRD gene is associated with squamous cell carcinomas of the vulva. PMID: 23404381
25. Polymorphism in protein tyrosine phosphatase receptor delta is associated with the risk of clear cell renal cell carcinoma. PMID: 23069849
26. This is the first report to observe an association between deletion within PTPRD and metastatic cutaneous squamous cell carcinoma. PMID: 22052591
27. Although endogenous PTPdelta expression was very low in neuroblastoma cells, it was also low in mouse embryo adrenal glands, suggesting that PTPdelta may have little developmental function in early adrenal neuroblasts. PMID: 22571343
28. Data indicate that genetic variants near the KCNQ1 and MAF/WWOX genes are associated with reduced insulin secretion, and the PTPRD genetic variant appears to be associated with progression to diabetes in Han Chinese. PMID: 21767287
29. PTPRD has a tumor suppressor function in neuroblastoma through AURKA dephosphorylation and destabilization and a downstream destabilization of MYCN protein, representing a novel mechanism for the function of PTPRD in neuroblastoma. PMID: 22305495
30. The interaction of the IL1RAPL1 family of proteins with PTPdelta and RhoGAP2 reveals a pathophysiological mechanism of cognitive impairment associated with a novel type of trans-synaptic signaling. PMID: 21926414
31. Eight suggestive significant loci were detected with a series of genes expressed within the inner ear that underlie the auditory function, such as: DCLK1, PTPRD, GRM8, CMIP. PMID: 21493956
32. Both family-based and population-based association studies suggest that PTPRD variant rs1975197 confers risk of RLS. PMID: 21264940
33. statistical significant downregulation of PCDH17/PCH68 and PTPRD was observed PMID: 21213369
34. Results found the PTPRD gene was most frequently homozygously deleted gene in human lung cancer among genes mapping to regions other than 9p21. PMID: 20073072
35. Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation. PMID: 20139422
36. A novel isoform of PTPRD was cloned and its expression analyzed. PMID: 16114034
37. data identify PTPRD as a candidate tumor suppressor gene in cutaneous squamous cell carcinoma with a possible association with metastasis PMID: 17420988
38. The aberrant splicing or microdeletion of 5' UTR exons in such a high proportion of tumors indicates that loss of these exons dys-regulates the mRNA sequence PMID: 18050303
39. The results indicate that polymorphisms of PTPRD are strongly associated with pediatric bronchial asthma in the Taiwanese population. PMID: 18414509
40. Two independent SNPs in the 5' UTR of splice variants expressed predominantly in the central nervous system showed highly significant P values, identifying PTPRD as the fourth genome-wide significant locus for restless legs syndrome. PMID: 18660810
41. These results implicate PTPRD as a tumor suppressor on chromosome 9p that is involved in the development of glioblastoma multiforme and multiple human cancers. PMID: 19478061
42. No mutations of PTPRD were associated with familiar melanoma PMID: 19500277
43. Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study PMID: 19525478

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HGNC: 9668

OMIM: 601598

KEGG: hsa:5789

STRING: 9606.ENSP00000348812

UniGene: Hs.446083