PTPRD

PTPRD, also known as protein tyrosine phosphatase receptor type D, is a receptor-type tyrosine-protein phosphatase that plays a crucial role in regulating various cellular processes. It contains an extracellular region with Ig-like and fibronectin type III-like domains, and its function is to promote neurite growth and regulate neuron axon guidance. PTPRD interacts with other proteins like PTPRS and liprin-alpha-1, and it is involved in the STAT3 pathway, which is associated with endometriosis and endometrial cancer. Mutations in the PTPRD gene have been linked to autism, obsessive-compulsive disorder, and breast cancer, indicating its importance in neurobiology and oncology.
PTPRD's role in the orexigenic receptor of asprosin suggests its potential in metabolic regulation. Research into PTPRD has led to the identification of its involvement in obesity resistance and appetite regulation. The study of PTPRD also opens avenues for drug development, particularly in targeting the STAT3 pathway for treating related diseases.