Recombinant Human Peroxiredoxin-like 2A (PRXL2A)

Code CSB-YP883589HU
MSDS
Size Pls inquire
Source Yeast
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Code CSB-EP883589HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP883589HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP883589HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
FAM213A
Uniprot No.
Alternative Names
C10orf58; CJ058_HUMAN; UPF0765 protein C10orf58
Species
Homo sapiens (Human)
Expression Region
1-229
Target Protein Sequence
MSFLQDPSFF TMGMWSIGAG ALGAAALALL LANTDVFLSK PQKAALEYLE DIDLKTLEKE PRTFKAKELW EKNGAVIMAV RRPGCFLCRE EAADLSSLKS MLDQLGVPLY AVVKEHIRTE VKDFQPYFKG EIFLDEKKKF YGPQRRKMMF MGFIRLGVWY NFFRAWNGGF SGNLEGEGFI LGGVFVVGSG KQGILLEHRE KEFGDKVNLL SVLEAAKMIK PQTLASEKK
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass. Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway.
Gene References into Functions
  1. Antioxidant stress induces PAMM mRNA expression in human peripheral blood mononuclear cells . PMID: 26402163
  2. results suggest that adipocyte-derived PAMM may suppress macrophage activation by inhibiting MAPK signalling pathway. PMID: 26438880
  3. The PAMM is a redox regulatory protein that modulates osteoclast differentiation in vitro. PAMM expression may affect bone resorption in vivo and help to maintain bone mass. PMID: 19951071
Subcellular Location
Cytoplasm. Secreted.
Protein Families
Peroxiredoxin-like FAM213 family, FAM213A subfamily
Tissue Specificity
Expressed in CSF1 and TNFSF11-stimulated CD14(+) peripheral blood mononuclear cells (PBMCs).
Database Links

HGNC: 28651

OMIM: 617165

KEGG: hsa:84293

STRING: 9606.ENSP00000361254

UniGene: Hs.500333

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