Recombinant Human Regucalcin (RGN)

1. Study suggests that regucalcin plays a crucial role as a suppressor in human colorectal cancer, and that the suppressed expression of the regucalcin gene may predispose patients to the promotion of colorectal cancer. PMID: 29956741
2. The SMP30 may serve as a candidate of HCC clinical prognostic marker. PMID: 27991558
3. Dat show that regucalcin (RGN) is lowly expressed in hepatocellular carcinoma (HCC) tissues and down-regulates the proliferation ability of HepG2 cells. PMID: 28028056
4. These findings suggest that regucalcin may play a potential role as a suppressor of human lung cancer, and that downregulation of regucalcin expression may predispose patients to development of lung cancer. PMID: 28181135
5. The role of RGN suppressing cell proliferation is associated with the regulation of expression of oncogenes and tumor suppressor genes. [review] PMID: 27411833
6. High RGN expression is associated with hepatocellular carcinoma. PMID: 27633001
7. the present study suggests that regucalcin may have important anticancer properties in human breast cancer patients. Mechanistically, these effects are likely mediated through suppression of multiple signaling pathways, upregulation of p53 and downregulation of oncogenes leading to anti-proliferative effects and reduced metastases to bone, a phenotype associated with poor clinical outcome. PMID: 27221776
8. Study demonstrates that increased regucalcin gene expression greatly contributes to prolonged survival in human pancreatic cancer patients. Morover, overexpression of regucalcin was found to suppress the proliferation, which is enhanced through various signaling pathways. PMID: 26935290
9. Study results suggest that senescence marker protein-30 and senescence-associated beta-galactosidase expressions in both nuclear cataract and cortical cataract patients were associated with lens epithelial cells apoptosis. PMID: 26619319
10. data suggest that exogenous regucalcin exerts suppressive effects on the proliferation of human pancreatic cancer cells. PMID: 25847529
11. immunohistochemistry revealed a significant decrease of regucalcin in human kidney disease tissue vs control kidney tissue, and regucalcin was detected in exosomes isolated from healthy donors' urine but not from kidney disease patients PMID: 26072307
12. results highlighted the importance of RGN as a regulatory protein in Ca2+-dependent signaling pathways and its deregulation of RGN expression by Ca2+o may contribute for onset and progression of PCa. PMID: 26171977
13. This review will discuss regarding to an involvement of regucalcin as a suppressor protein in human carcinogenesis in insight into the gene therapy. [review] PMID: 25230901
14. The alternatively spliced variants of the regucalcin gene were found to be expressed in various human normal and tumor tissues. PMID: 25050833
15. RGN overexpression protected from carcinogen-induced mammary gland tumor development and was linked with reduced proliferation and increased apoptosis. These findings indicated the protective role of RGN in the carcinogenesis of mammary gland. PMID: 25128811
16. SMP30 can inhibit the proliferation and invasion of human hepatoma cells and thus can be regarded as a cancer suppressive factor. PMID: 24606440
17. Overexpression of prostate RGN transgene in the prostate inhibits cell proliferation and apoptotic pathways. PMID: 24975685
18. Regucalcin may be a key molecule in lipid metabolic disorder and diabetes--{review} PMID: 23453039
19. structural feature of mouse SMP30/GNL seems to facilitate the gamma-lactone-ring formation PMID: 23349732
20. Regucalcin may play a pivotal role in the regulation of Ca(2+) signaling which is stimulated through a neurotransmitter in the brain neurons with aging PMID: 22652898
21. RGN has a role in spermatogenesis, directly or as a mediator of androgen action. [review] PMID: 22121208
22. existence of multiple forms of SMP30 PMID: 21347421
23. Rgn is a novel androgen-target gene in testis and may have a role in male reproductive function, particularly in the control of spermatogenesis. PMID: 21680783
24. Studies indicate that regucalcin plays an important role as a regulatory protein in cell signaling system, and it is proposed to play a pivotal role in keep of cell homeostasis and function. PMID: 21431902
25. Data show that regucalcin (RGN) reduces agonist (histamine)-induced Ca(2+) transients in RGN(+) transfected COS-7 cells (RGN(+)) and also increases their Ca(2+) storage capacity. PMID: 21684279
26. SMP30 may be useful for hepatocellular carcinoma serologic screening, especially for the patients that are alpha-fetaprotein negative. PMID: 21047503
27. These results suggest that hepatic SMP30 is closely associated with the pathogenesis of nonalcoholic fatty liver disease, although it is not known whether decreased hepatic SMP30 is a result or a cause of cirrhosis PMID: 19946731
28. over-expression of SMP30/GNL in Hep G2 cells contributed to a decrease of reactive oxygen species formation accompanied by decreases of lipid peroxidation, superoxide dismutase activity and glutathione levels PMID: 19801822
29. a domain of the SMP30 sequence 51 amino acid residues long was 60-66% similar to bacterial and yeast RNA polymerases PMID: 12619687
30. SMP30 acts as a survival factor in hepatocytes PMID: 15358188
31. crystal structure of regucalcin PMID: 15502314
32. SMP30 induces formation of microvilli and bile canaliculi in HepG2 cells. PMID: 15714273
33. regucalcin plays an important role as a suppressor in the enhancement of cell proliferation PMID: 15962315
34. SMP30 also plays a very important role in a self-protective mechanism in survival and participates in the pathophysiological processes of acute liver failure. PMID: 18507831
35. effect of sex steroid hormones on regucalcin expression in breast and prostate cancer cells suggest that it may be associated with development and progression of these human tumors PMID: 19347872
36. Data suggest that through regucalcin and L-gulonolactone oxidase expression, beta-catenin regulates vitamin C biosynthesis in liver. PMID: 19690176

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HGNC: 9989

OMIM: 300212

KEGG: hsa:9104

STRING: 9606.ENSP00000253303

UniGene: Hs.77854