Recombinant Human SCL-interrupting locus protein (STIL), partial

1. Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly. PMID: 29712910
2. Results from a study on gene expression variability markers in early-stage human embryos shows that STIL is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
3. we observed that depletion of STIL enhanced canonical homologous recombination repair and increased BRCA1 and RAD51 foci in response to DNA double strand breaks. Thus, inhibition of STIL significantly enhances the efficacy of DNA damaging chemotherapeutic drugs in treatment of ovarian cancer. PMID: 28423708
4. These data show that complementary mechanisms, such as mother-daughter centriole proximity and CDK1-CyclinB interaction with centriolar components, ensure that centriole biogenesis occurs once and only once per cell cycle, raising parallels to the cell-cycle regulation of DNA replication and centromere formation. PMID: 27112295
5. RTTN directly interacts with STIL and acts downstream of STIL-mediated centriole assembly, contributing to building full-length centrioles. PMID: 28811500
6. Deletions of Stil is associated with acute T-lymphoblastic leukemia. PMID: 27759908
7. Studies indicate that depletion of any one of the protein kinase polo-like kinase 4 (PLK4) and the two proteins STIL and SAS-6 blocks centriole duplication, and, conversely, overexpression causes centriole amplification. PMID: 27911707
8. Reconstituting mouse embryonic fibroblasts lacking endogenous Stil, the authors show that STIL oligomerization mediated by these residues is not only important for the centrosomal functions of STIL during the canonical duplication process but also for de-novo formation of centrosomes. PMID: 27075531
9. Egyptian T-cell acute lymphoblastic leukemia cases seemed to have a different genetic pattern compared to other populations, with a lower incidence of TLX3/HOX11L2 and SIL/TAL but a higher incidence of NKX2-5 expression than recorded in Western countries PMID: 24571118
10. data provide evidence for novel functions of the human oncogene Stil in neural toxic susceptibility. PMID: 26549353
11. The authors suggest that the STIL-coiled-coil region/PLK4 interaction mediates PLK4 activation as well as stabilization of centriolar PLK4 and plays a key role in centriole duplication. PMID: 26188084
12. The STIL p.Gly717Glu mutation was not able to fully restore the centriole duplication failure following depletion of endogenous STIL protein indicating the deleterious role of the mutation. PMID: 25658757
13. Negative feedback by centriolar STIL regulates bimodal centriolar distribution of Plk4 and seemingly restricts occurrence of procentriole formation to one site on each parental centriole. PMID: 25342035
14. studies provide the first structural insight into how the malfunction of centriole proteins results in human disease and also reveal that the CPAP-STIL interaction constitutes a conserved key step in centriole biogenesis PMID: 24052813
15. STIL mutation causes autosomal recessive microcephalic lobar holoprosencephaly. PMID: 25218063
16. propose that centriole amplification triggered by STIL stabilization is the underlying cause of microcephaly in human patients with corresponding STIL mutations PMID: 24485834
17. results provide direct evidence for the involvement of Stil in dopaminergic cell proliferation PMID: 24853807
18. A novel function for Stil protein is neural progenitor cell proliferation but not neural differentiation. PMID: 24240054
19. Identification of a novel STIL mutation in a family with primary microcephaly. PMID: 22989186
20. STIL cooperates with SAS-6 and PLK4 in the control of centriole number and represents a key centriole duplication factor in human cells. PMID: 22349698
21. These findings demonstrate that STIL is an essential component of the centriole replication machinery in mammalian cells. PMID: 22349705
22. STIL and CPAP are essential for centriole formation and for proper spindle position. PMID: 22100914
23. STIL depletion inhibited normal centriole duplication, Plk4-induced centriole amplification, and CPAP-induced centriole elongation, and resulted in a failure to localize hSAS6 and CPAP to the base of the nascent procentriole. PMID: 22020124
24. dHPLC techniques were used to screen for mutations and these studies identified several common polymorphisms but no disease-associated mutations, suggesting that SIL is not a common factor in holoprosencephaly pathogenesis in humans. PMID: 12438740
25. isolation and characterization of a cloned promoter as well as its role in leukemogenesis PMID: 12531481
26. Children with t-cell malignancies and with SIL-TAL fusion had low levels of residual disease at the end of induction and a favorable prognosis PMID: 14504110
27. Sil has a role in increased mitotic activity in tumor cells PMID: 15107824
28. Cell cycle-dependent phosphorylation of Sil is required for its interaction with Pin1, a regulator of mitosis. PMID: 16024801
29. SIL is important for the transition from the G(2) to the M phases of the cell cycle. Inducible knockdown of SIL in cancer cells in vitro delayed entrance into mitosis, decreased activation of the CDK1 (CDC2)-cyclin B complex, and induced apoptosis. PMID: 17456584
30. Mice carrying both SILloxloxSCL and Cre transgenes have increased CD4-negative/CD8-negative thymocytes compared with transgene-negative mice. PMID: 17460775
31. These data, taken together, identify SIL as a novel, vertebrate-specific regulator of mitotic spindle assembly. PMID: 17576815
32. LMO2, TAL1, Ttg-1, and SIL support levels of V(D)J recombination above background levels in cell culture and are also cleaved by the RAG proteins, while Hox11 and SCL are nicked but not cleaved efficiently in vitro PMID: 18187418
33. A role ofor SIL in derepressing GLI1 from the negative control of SUFU. PMID: 18829525
34. Primary microcephaly is an autosomal-recessive congenital disorder characterized by smaller brain size and mental retardation, in which homozygote mutations in STIL proteins are found. PMID: 19215732

Show More

Hide All

HGNC: 10879

OMIM: 181590

KEGG: hsa:6491

STRING: 9606.ENSP00000360944

UniGene: Hs.525198