Recombinant Human SPARC-related modular calcium-binding protein 2 (SMOC2)

In Stock
Code CSB-EP884462HU
Abbreviation Recombinant Human SMOC2 protein
MSDS
Size $388
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Product Details

Purity
Greater than 85% as determined by SDS-PAGE.
Activity
Not Test
Target Names
Uniprot No.
Research Area
Cardiovascular
Alternative Names
Secreted modular calcium-binding protein 2;SMOC-2;Smooth muscle-associated protein 2;SMAP-2
Species
Homo sapiens (Human)
Source
E.coli
Expression Region
22-446aa
Target Protein Sequence
QKFSALTFLRVDQDKDKDCSLDCAGSPQKPLCASDGRTFLSRCEFQRAKCKDPQLEIAYRGNCKDVSRCVAERKYTQEQARKEFQQVFIPECNDDGTYSQVQCHSYTGYCWCVTPNGRPISGTAVAHKTPRCPGSVNEKLPQREGTGKTDDAAAPALETQPQGDEEDIASRYPTLWTEQVKSRQNKTNKNSVSSCDQEHQSALEEAKQPKNDNVVIPECAHGGLYKPVQCHPSTGYCWCVLVDTGRPIPGTSTRYEQPKCDNTARAHPAKARDLYKGRQLQGCPGAKKHEFLTSVLDALSTDMVHAASDPSSSSGRLSEPDPSHTLEERVVHWYFKLLDKNSSGDIGKKEIKPFKRFLRKKSKPKKCVKKFVEYCDVNNDKSISVQELMGCLGVAKEDGKADTKKRHTPRGHAESTSNRQPRKQG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
Mol. Weight
54.4 kDa
Protein Length
Full Length of Mature Protein
Tag Info
C-terminal 6xHis-tagged
Form
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
3-7 business days
Datasheet & COA
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Promotes matrix assembly and cell adhesiveness. Can stimulate endothelial cell proliferation, migration, as well as angiogenesis.
Gene References into Functions
  1. SMOC2 was highly expressed in both peritoneal and endometrioma lesions. Considering that the genes studied participate either directly or indirectly in cellular processes that can lead to cell migration, angiogenesis, and inappropriate invasion, it is possible that the deregulation of these genes caused the development and maintenance of ectopic tissue. PMID: 28678915
  2. The expression of Smoc2 was significantly higher in hepatocellular carcinoma (HCC) tissues compared with corresponding non-tumor liver tissues. Smoc2 promotes the proliferation of HCC cells through accelerating cell cycle progression. PMID: 28018113
  3. L1-mediated CRC progression involves the acquisition of a stem cell-like phenotype, and that SMOC-2 elevation is necessary for L1-mediated induction of more aggressive/invasive CRC properties. PMID: 25915847
  4. could not detect an association between SMOC2 gene and AMD. This study tests the candidacy of SMOC2 gene to the etiology of AMD PMID: 22964816
  5. SMOC2 SNP may play a role in autoimmune thyroid disease susceptibility as a dominant polymorphism. PMID: 23463390
  6. mutation in exon 8 of the SMOC2 gene linked to oligodontia PMID: 23317772
  7. Homozygosity mapping and candidate prioritization identify mutations, missed by whole-exome sequencing, in SMOC2, causing major dental developmental defects PMID: 22152679
  8. The variant rs13208776 in SMOC2 gene does not play a major role in increasing the risk of vitiligo in Jordanian Arab patients. PMID: 20965805
  9. SMOC2 is a risk locus for generalized vitiligo and perhaps other autoimmune diseases PMID: 19890347
  10. identification of gene, chromosome mapping PMID: 12741954
  11. SMOC-2 is a novel angiogenic factor that potentiates angiogenic effects of growth factors PMID: 16774925
  12. We tested association between SMOC2 polymorphisms and FEV(1) and FVC. SMOC2 might play an important role in the determination of FEV(1) and FVC PMID: 17204727
  13. Although this study specifies rat, the authors studied and discussed the human gene in this study as well. PMID: 12031507

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Involvement in disease
Dentin dysplasia 1 (DTDP1)
Subcellular Location
Secreted, extracellular space, extracellular matrix, basement membrane.
Database Links

HGNC: 20323

OMIM: 125400

KEGG: hsa:64094

STRING: 9606.ENSP00000346537

UniGene: Hs.487200

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