Recombinant Human Sal-like protein 2 (SALL2), partial

1. Sall2 may play a significant role in NIT-1 cell function. PMID: 29783189
2. Using RNA interference, the role of Spalt-like gene-2 (SALL2) was investigated in human ovarian carcinoma (OC) A2780 cells. Found downregulation of SALL2 promoted growth of the OC cell line. PMID: 29228922
3. Understanding SALL2 function and the molecular mechanisms governing its expression and activity is critical to comprehend why and how SALL2 could contribute to disease. This knowledge will open new perspectives for the development of molecular targeted approaches in disease PMID: 28430874
4. Sall2 enhanced the p16 minigene blocking of cell cycle progression and p16 knockdown with siRNA abolished most of the Sall2 inhibition of cell cycle progression PMID: 25580951
5. Mechanisms of silencing SALL2 in OVCA cell lines and primary tumors and possible therapeutic approaches for ovarian carcinoma are discussed in this review. PMID: 25608837
6. A role for SALL2 in eye morphogenesis and loss of function of the gene causes ocular coloboma in humans and mice. PMID: 24412933
7. The SALL2 P2 promoter is hypermethylated in a majority of serous ovarian carcinomas. PMID: 23273547
8. c-MYC may come under negative regulation by p150, consistent with the action of p150 as a putative tumor suppressor. PMID: 23029531
9. Here, the authors report that human papillomavirus type 16 E6 targets the cellular factor p150(Sal2), which positively regulates p21(WAF1) transcription. PMID: 21791360
10. Results demonstrate binding of p150(Sal2) to two natural promoters with GC elements related to the optimal binding sequence defined in vitro and whose regulation is important for suppression of tumor growth. PMID: 21362508
11. A CUL4/DDB1 E3 ligase containing RBBP7 as the p150(Sal2) receptor has been identified as mediating the destruction of p150(Sal2) as cells transition from a quiescent to an actively growing state. PMID: 21228219
12. Studies indicate that vertebrate sal orthologues (spalt-like/sall) have important developmental roles during neural development and organogenesis and gentic diseases. PMID: 19247946
13. Epidermal growth factor receptor (a potential therapeutic target) and SALL2 stained most cases of synovial sarcoma; staining was significantly less common among other tested sarcomas. PMID: 14507652
14. Results suggest that p150(Sal2), acting in part as a p53-independent regulator of p21 and BAX, can function in some cell types as a regulator of cell growth and survival [p150(Sal2)] PMID: 15082782
15. These data establish Sall2 as a link between p75 neurotrophin receptor and transcriptional events that regulate the growth and development of neuronal cells. PMID: 19131967

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HGNC: 10526

OMIM: 216820

KEGG: hsa:6297

STRING: 9606.ENSP00000333537

UniGene: Hs.416358