Recombinant Human Selenoprotein S (SELENOS SELS VIMP AD-015 SBBI8)

1. In these studies found that SelS increases in negative correlation with tau phosphorylation in brain. PMID: 27802219
2. The results suggest that SelS is required for C99 degradation through endoplasmic reticulum-associated degradation, resulting in inhibition of amyloid beta production. PMID: 28315680
3. regulating liver and serum Selenoprotein S levels might become a new strategy for the prevention and treatment of DM and its macrovascular complications PMID: 27121097
4. SEPS1 may be a potential gene marker for disease diagnosis and prognosis. PMID: 26382012
5. interaction between SelK and p97(VCP) is SelS-dependent, and the resulting ERAD complex (SelS-p97(VCP)-SelK) plays an important role in ERAD and ER stress PMID: 26504085
6. Potential roles of the SEPS1 gene in the pathogenesis and etiology of Hashimoto's thyroiditis. PMID: 26016409
7. SNP rs4965814 of SELS may affect the susceptibility to ischemic stroke. PMID: 25390504
8. The SEPS1 -105G>A is associated with an increased risk of Kashin-Beck disease and influences the expression of PI3K/Akt signaling pathway in Kashin-Beck disease patients PMID: 25433273
9. Although VIMP can interact with CLIMP-63 and Syn5L, it does not interact with MT-binding ER proteins (such as Reep1) that shape the tubular smooth ER PMID: 25008318
10. Selenoprotein S is a marker but not a regulator of endoplasmic reticulum stress in intestinal epithelial cells in inflammatory bowel diseases. PMID: 24275540
11. Pro(178) and Pro(183) of SelS play important roles in the translocation of p97(VCP) to the ER membrane and protect cells from ER stress PMID: 24700463
12. that SEPS1 may protect mice against LPS-induced sepsis and organ damage. Therefore, SEPS1 may be a new target to resolve LPS-induced sepsis. PMID: 24573439
13. Existence of a link between SEPS1 promoter genetic variation and Hashimoto thyroiditis risk. PMID: 24471570
14. Findings suggest that the SEPS1 G-105A polymorphism contributes to the risk of developing SPTB in a Chinese population. PMID: 23776519
15. Our results indicated that the rs12910524 in the Tanis gene was associated with triglyceride concentrations in subjects without diabetes in China. PMID: 23829426
16. Data suggest that selenocysteine allows selenoprotein S (SelS, VIMP) to sustain activity under oxidative stress. PMID: 23914919
17. These results suggest a potential role for the SELS region in the development subclinical cardiovascular disease in this sample enriched for type 2 diabetes mellitus. PMID: 23161441
18. the redox properties observed for recombinant VIMP are compatible with a function as a reductase PMID: 22700979
19. Upregulation of SelS expression in reactive astrocytes reveals a new protective role for SelS against inflammation and endoplasmic reticulum stress that can be relevant to astrocyte function. PMID: 21456042
20. a role for SELS in the development of metabolic disease, especially in the context of insulin resistance. PMID: 20619427
21. beta-ME, also an ER stress agent, could induce cell apoptosis, and SelS may play an important role in protecting cells from apoptosis induced by ER stress in HepG2 cells. PMID: 20114070
22. SELS is regulated by glucose deprivation and endoplasmic reticulum stress. It is a glucose-regulated protein. PMID: 15063746
23. Positive relationship between Tanis mRNA and the acute-phase protein serum amyloid A suggests an interaction between innate immune system responses and Tanis expression in muscle and adipose tissue. PMID: 15161744
24. Derlin-1 interacts with US11, a virally encoded ER protein that specifically targets MHC class I heavy chains for export from the ER, as well as with VIMP, a novel membrane protein that recruits the p97 ATPase and its cofactor PMID: 15215856
25. SEPS1 may regulate cytokine production in macrophage cells and there may be a regulatory loop between TNF-alpha, IL-1beta and SEPS1 that plays a key role in control of the inflammatory response PMID: 16574427
26. SEPS1 protein is secreted from hepatoma cells. Fractionation of human serum indicated that SEPS1 was associated with LDL and possibly with VLDL. PMID: 17374524
27. significant association with increased CHD risk in females carrying the minor allele of rs8025174. Another variant, rs7178239, increased the risk for ischemic stroke significantly in females. PMID: 17641917
28. -105G>A polymorphism is not associated with IBD susceptibility and does not contribute to a certain disease phenotype or increased TNF-alpha levels in IBD patients. PMID: 17661913
29. Selenoprotein S -105(adenosine) allele is a non-significant risk factor in young stroke patients from Italy and Germany. PMID: 17880573
30. Six polymorphisms were studied in this gene, and none are associated with type 1 diabetes, rheumatoid arthritis or inflammatory bowel diseases. PMID: 18625033
31. SelS has a role in lipopolysaccharide-induced inflammatory response in hepatoma HepG2 cells PMID: 18675776
32. SelS protein may be involved in insulin resistance in Chinese with type 2 diabetes mellitus (T2DM) by acting as the SAA receptor, thus playing an important role in the development of T2DM and atherosclerosis PMID: 18710632
33. The -105G>A promoter polymorphism of SEPS1 was associated with the intestinal type of gastric cancer. PMID: 19144102
34. Selenoprotein S/SEPS1 modifies endoplasmic reticulum stress in Z variant alpha1-antitrypsin deficiency. PMID: 19398551
35. Regulatory variant in SELS influences inflammatory response to ER stress PMID: 16227999

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HGNC: 30396

OMIM: 607918

KEGG: hsa:55829

STRING: 9606.ENSP00000381282

UniGene: Hs.32148