Recombinant Human Serine/threonine-protein kinase MARK2 (MARK2)

1. In cell-based assays, Mark2 depletion indeed reduces Dvl gene expression and interrupts neural stem cell (NSCs) growth and differentiation, which are likely to be mediated through a decrease in class IIa HDAC phosphorylation and reduced H3K4ac and H3K27ac occupancies at the Dvl1/2 promoters. PMID: 27714636
2. HIV-1 did not stimulate widespread FEZ1 phosphorylation but, instead, bound microtubule (MT) affinity-regulating kinase 2 (MARK2) to stimulate FEZ1 phosphorylation on viral cores. PMID: 28930676
3. Low expression of Mark2 is associated with uterine cervical neoplasms. PMID: 28560405
4. In this study, through quantitative analysis of the complex formation between CagA and PAR1b, the authors found that several CagA species have acquired elevated PAR1b-binding activity via duplication of the CagA multimerization motifs, while others have lost their PAR1b-binding activity. PMID: 27445265
5. In the modeled structure of inactive MARK2, activation segment occludes the enzyme active site and assumes a relatively stable position. PMID: 28711359
6. In conclusion, baicalin and DDP were synergistic at inhibiting proliferation and invasion of human lung cancer cells at appropriate dosages and incubation time in the presence or absence of DDP resistance. The attenuation of DDP resistance was associated with downregulation of MARK2 and p-Akt. PMID: 27878245
7. MARK2 plays a role in promoting malignant phenotypes of lung cancer. PMID: 25907283
8. Phosphorylation of RNF41 by Par-1b regulates basolateral membrane targeting of laminin-111 receptors. PMID: 24259665
9. induces asymmetric inheritance of plasma membrane domains via LGN-dependent mitotic spindle orientation in proliferating hepatocytes PMID: 24358023
10. Perturbation of PAR1b and SHP2 by CagA underlies the oncogenic potential of CagA. PMID: 24354359
11. The MARK2 binds to the N-terminal tail of Tau and selectively phosphorylates three major and five minor serine residues in the repeat domain and C-terminal tail. PMID: 24251416
12. Hepatocyte Par1b defines lumen position in concert with the position of the astral microtubule anchoring complex LGN-NuMA to yield the distinct epithelial division phenotypes. PMID: 24165937
13. automated image analysis of MT assembly dynamics identified MARK2 as a target regulated downstream of Rac1 that promotes oriented MT growth in the leading edge to mediate directed cell migration. PMID: 22848487
14. The scaffolding adaptor GAB1 interacts with two polarity proteins, PAR1 and PAR3. PMID: 22883624
15. The results identify MARK2 as an upstream regulator of PINK1 and DeltaN-PINK1 and provide insights into the regulation of mitochondrial trafficking in neurons and neurodegeneration in PD. PMID: 22238344
16. Polarity-regulating kinase partitioning-defective 1b (PAR1b) phosphorylates guanine nucleotide exchange factor H1 (GEF-H1) to regulate RhoA-dependent actin cytoskeletal reorganization. PMID: 22072711
17. These data suggest that Par1b-phosphorylation regulates turnover of GEF-H1 localization by regulating its interaction with microtubules, which may contribute to cell polarization. PMID: 21513698
18. These results reveal that GAKIN/KIF13B is a key intermediate linking Par1b to the regulation of axon formation. PMID: 20194617
19. the 8th and 9th spectrin-like repeats (R8 and R9) of utrophin cooperatively form a PAR-1b-interacting domain, and that Ser1258 within R9 is specifically phosphorylated by PAR-1b. PMID: 19945424
20. Par1/Emk1 could have a role in the development of chronic allograft nephropathy in kidney allografts PMID: 15158914
21. Flot-2 binds to PAR-1, a known upstream mediator of major signal transduction pathways implicated in cell growth and metastasis, and may thereby influence tumor progression in melanoma. PMID: 15492257
22. GSK-3beta directly phosphorylates and activates MARK2/PAR-1 PMID: 16257959
23. The X-ray structure of the catalytic and ubiquitin-associated domains of human MARK2. PMID: 16472737
24. analysis of variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2 PMID: 16803889
25. Class IIa histone deacetylases (HDACs) are subjected to signal-independent nuclear export that relies on their constitutive phosphorylation. EMK and C-TAK1, are identified as regulators of this process. PMID: 16980613
26. Aberrant activation of PAR-1 may provide one of the molecular links in the pathogenic cascade of tauopathies. PMID: 17234589
27. We demonstrate that H. pylori causes the recruitment of MARK2 from the cytosol to the plasma membrane, where it colocalizes with the bacteria and interacts with CagA.[CagA in strain G27] PMID: 18005242
28. PAR-1 can be used with Breslow thickness and ulceration as a prognostic indicator for melanoma. PMID: 18315603
29. findings show protein kinase D phosphorylates Par-1b on S400 to positively regulate 14-3-3 binding and to negatively regulate membrane association PMID: 19011111
30. Par1b functions in the establishment of T cell polarity following engagement to an APC PMID: 19553522

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HGNC: 3332

OMIM: 600526

KEGG: hsa:2011

STRING: 9606.ENSP00000385751

UniGene: Hs.567261