Recombinant Human Sodium/hydrogen exchanger 9 (SLC9A9), partial

Code CSB-YP818234HU
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Source Yeast
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Code CSB-EP818234HU
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Source E.coli
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Code CSB-EP818234HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP818234HU
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Source Baculovirus
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Code CSB-MP818234HU
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
5730527A11Rik; 9930105B05; AI854429; FLJ35613; Na(+)/H(+) exchanger 9; Nbla00118; NHE 9; NHE-9; NHE9; Putative protein product of Nbla00118; SL9A9_HUMAN; Slc9a9; Sodium/hydrogen exchanger 9; Sodium/proton exchanger NHE9; Solute carrier family 9 (sodium/hydrogen exchanger) isoform 9; Solute carrier family 9 (sodium/hydrogen exchanger) member 9; Solute carrier family 9 member 9
Homo sapiens (Human)
Protein Length
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell.
Gene References into Functions
  1. downregulation of miR-135a as a potential mechanism underlying the high NHE9 expression observed in subset of glioblastomas PMID: 29268774
  2. SLC9A9 is a sodium hydrogen exchanger present in the recycling endosome and highly expressed in the brain. PMID: 27439572
  3. SLC9A9 has an oncogenic function by being related to EGFR signaling, suggesting SLC9A9 may be a novel prognostic indicator and a therapeutic target in colorectal cancer PMID: 28476790
  4. Ectopic expression of NHE9 in human brain microvascular endothelial cells without external cues induced up-regulation of the transferrin receptor (TfR) and down-regulation of ferritin, leading to an increase in iron uptake PMID: 28130443
  5. Taken together, our findings demonstrate that NHE9 can be an effective predictor of chemoradiotherapy response in esophageal squamous cell carcinoma PMID: 25915159
  6. the expression of SLC9A9 can be a prognostic predictor for ESCC. PMID: 25835977
  7. SLC9A9 appears to influence the differentiation of T cells to a proinflammatory fate and may have a broader role in multiple sclerosis disease activity. There is an association between rs9828519(G) and nonresponse to IFNbeta treatment. PMID: 25914168
  8. find interesting gene expression changes in endosomal NHE6 and NHE9 in postmortem autism brains. PMID: 23508127
  9. Loss-of-function mutations in NHE9 may contribute to autistic phenotype by modulating synaptic membrane protein expression and neurotransmitter clearance. PMID: 24065030
  10. 33 directly measured and 13 derived glycosylation traits in 3533 individuals were identified and three novel gene association (MGAT5, B3GAT1 and SLC9A9) were identified using an additional European cohort. PMID: 21908519
  11. SLC9A9 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
  12. This review defines NHE6-9 as organellar NHEs that are fairly dynamic, implying that they are subjected to intracellular trafficking and thus they continuously shuttle between organelles and the plasma membrane. PMID: 21171650
  13. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20732626
  14. results suggest that SLC9A9 may be related to hyperactive-impulsive symptoms in AD/HD and the disruption of SLC9A9 may be responsible for the behavioral phenotype observed in the inversion family PMID: 20032819
  15. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
  16. Observational study of gene-disease association. (HuGE Navigator) PMID: 20032819
  17. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 19268276
  18. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 18937294
  19. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 18821565
  20. Observational study of gene-disease association. (HuGE Navigator) PMID: 18649358

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Involvement in disease
Autism 16 (AUTS16)
Subcellular Location
Late endosome membrane; Multi-pass membrane protein.
Protein Families
Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
Tissue Specificity
Ubiquitously expressed in all tissues tested. Expressed at highest levels in heart and skeletal muscle, followed by placenta, kidney, and liver. Expressed in the brain, in the medulla and spinal cord.
Database Links

HGNC: 20653

OMIM: 608396

KEGG: hsa:285195

STRING: 9606.ENSP00000320246

UniGene: Hs.302257

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