SLC9A9 Antibody

Code CSB-PA973659
Size US$297
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  • Western blot analysis of extracts from RAW264.7 cells, NIH/3T3 cells and A549 cells, using SLC9A9 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SLC9A9 Polyclonal antibody
Uniprot No.
Target Names
SLC9A9
Alternative Names
5730527A11Rik antibody; 9930105B05 antibody; AI854429 antibody; FLJ35613 antibody; Na(+)/H(+) exchanger 9 antibody; Nbla00118 antibody; NHE 9 antibody; NHE-9 antibody; NHE9 antibody; Putative protein product of Nbla00118 antibody; SL9A9_HUMAN antibody; Slc9a9 antibody; Sodium/hydrogen exchanger 9 antibody; Sodium/proton exchanger NHE9 antibody; Solute carrier family 9 (sodium/hydrogen exchanger) isoform 9 antibody; Solute carrier family 9 (sodium/hydrogen exchanger) member 9 antibody; Solute carrier family 9 member 9 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from internal of Human SLC9A9.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell.
Gene References into Functions
  1. downregulation of miR-135a as a potential mechanism underlying the high NHE9 expression observed in subset of glioblastomas PMID: 29268774
  2. SLC9A9 is a sodium hydrogen exchanger present in the recycling endosome and highly expressed in the brain. PMID: 27439572
  3. SLC9A9 has an oncogenic function by being related to EGFR signaling, suggesting SLC9A9 may be a novel prognostic indicator and a therapeutic target in colorectal cancer PMID: 28476790
  4. Ectopic expression of NHE9 in human brain microvascular endothelial cells without external cues induced up-regulation of the transferrin receptor (TfR) and down-regulation of ferritin, leading to an increase in iron uptake PMID: 28130443
  5. Taken together, our findings demonstrate that NHE9 can be an effective predictor of chemoradiotherapy response in esophageal squamous cell carcinoma PMID: 25915159
  6. the expression of SLC9A9 can be a prognostic predictor for ESCC. PMID: 25835977
  7. SLC9A9 appears to influence the differentiation of T cells to a proinflammatory fate and may have a broader role in multiple sclerosis disease activity. There is an association between rs9828519(G) and nonresponse to IFNbeta treatment. PMID: 25914168
  8. find interesting gene expression changes in endosomal NHE6 and NHE9 in postmortem autism brains. PMID: 23508127
  9. Loss-of-function mutations in NHE9 may contribute to autistic phenotype by modulating synaptic membrane protein expression and neurotransmitter clearance. PMID: 24065030
  10. 33 directly measured and 13 derived glycosylation traits in 3533 individuals were identified and three novel gene association (MGAT5, B3GAT1 and SLC9A9) were identified using an additional European cohort. PMID: 21908519
  11. SLC9A9 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
  12. This review defines NHE6-9 as organellar NHEs that are fairly dynamic, implying that they are subjected to intracellular trafficking and thus they continuously shuttle between organelles and the plasma membrane. PMID: 21171650
  13. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20732626
  14. results suggest that SLC9A9 may be related to hyperactive-impulsive symptoms in AD/HD and the disruption of SLC9A9 may be responsible for the behavioral phenotype observed in the inversion family PMID: 20032819
  15. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
  16. Observational study of gene-disease association. (HuGE Navigator) PMID: 20032819
  17. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 19268276
  18. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 18937294
  19. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 18821565
  20. Observational study of gene-disease association. (HuGE Navigator) PMID: 18649358

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Involvement in disease
Autism 16 (AUTS16)
Subcellular Location
Late endosome membrane; Multi-pass membrane protein.
Protein Families
Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
Tissue Specificity
Ubiquitously expressed in all tissues tested. Expressed at highest levels in heart and skeletal muscle, followed by placenta, kidney, and liver. Expressed in the brain, in the medulla and spinal cord.
Database Links

HGNC: 20653

OMIM: 608396

KEGG: hsa:285195

STRING: 9606.ENSP00000320246

UniGene: Hs.302257

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