Product Details

Uniprot No.

Target Names

SLC9A9

Alternative Names

5730527A11Rik antibody; 9930105B05 antibody; AI854429 antibody; FLJ35613 antibody; Na(+)/H(+) exchanger 9 antibody; Nbla00118 antibody; NHE 9 antibody; NHE-9 antibody; NHE9 antibody; Putative protein product of Nbla00118 antibody; SL9A9_HUMAN antibody; Slc9a9 antibody; Sodium/hydrogen exchanger 9 antibody; Sodium/proton exchanger NHE9 antibody; Solute carrier family 9 (sodium/hydrogen exchanger) isoform 9 antibody; Solute carrier family 9 (sodium/hydrogen exchanger) member 9 antibody; Solute carrier family 9 member 9 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from the Internal region of Human NHE-9.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:40000

Protocols

Western Blotting(WB) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function

May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell.

Gene References into Functions

downregulation of miR-135a as a potential mechanism underlying the high NHE9 expression observed in subset of glioblastomas PMID: 29268774
SLC9A9 is a sodium hydrogen exchanger present in the recycling endosome and highly expressed in the brain. PMID: 27439572
SLC9A9 has an oncogenic function by being related to EGFR signaling, suggesting SLC9A9 may be a novel prognostic indicator and a therapeutic target in colorectal cancer PMID: 28476790
Ectopic expression of NHE9 in human brain microvascular endothelial cells without external cues induced up-regulation of the transferrin receptor (TfR) and down-regulation of ferritin, leading to an increase in iron uptake PMID: 28130443
Taken together, our findings demonstrate that NHE9 can be an effective predictor of chemoradiotherapy response in esophageal squamous cell carcinoma PMID: 25915159
the expression of SLC9A9 can be a prognostic predictor for ESCC. PMID: 25835977
SLC9A9 appears to influence the differentiation of T cells to a proinflammatory fate and may have a broader role in multiple sclerosis disease activity. There is an association between rs9828519(G) and nonresponse to IFNbeta treatment. PMID: 25914168
find interesting gene expression changes in endosomal NHE6 and NHE9 in postmortem autism brains. PMID: 23508127
Loss-of-function mutations in NHE9 may contribute to autistic phenotype by modulating synaptic membrane protein expression and neurotransmitter clearance. PMID: 24065030
33 directly measured and 13 derived glycosylation traits in 3533 individuals were identified and three novel gene association (MGAT5, B3GAT1 and SLC9A9) were identified using an additional European cohort. PMID: 21908519
SLC9A9 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
This review defines NHE6-9 as organellar NHEs that are fairly dynamic, implying that they are subjected to intracellular trafficking and thus they continuously shuttle between organelles and the plasma membrane. PMID: 21171650
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20732626
results suggest that SLC9A9 may be related to hyperactive-impulsive symptoms in AD/HD and the disruption of SLC9A9 may be responsible for the behavioral phenotype observed in the inversion family PMID: 20032819
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
Observational study of gene-disease association. (HuGE Navigator) PMID: 20032819
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 19268276
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 18937294
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 18821565
Observational study of gene-disease association. (HuGE Navigator) PMID: 18649358

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Involvement in disease

Autism 16 (AUTS16)

Subcellular Location

Late endosome membrane; Multi-pass membrane protein.

Protein Families

Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family

Tissue Specificity

Ubiquitously expressed in all tissues tested. Expressed at highest levels in heart and skeletal muscle, followed by placenta, kidney, and liver. Expressed in the brain, in the medulla and spinal cord.

Database Links

HGNC: 20653

OMIM: 608396

KEGG: hsa:285195

STRING: 9606.ENSP00000320246

UniGene: Hs.302257

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Code	CSB-PA003449
Size	US$100
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Image	Western Blot analysis of RAW264.7 cells using NHE-9 Polyclonal Antibody Western Blot analysis of Jurkat K562 NIH-3T3 cells using NHE-9 Polyclonal Antibody
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SLC9A9 Antibody

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Target Background