Recombinant Human Solute carrier family 2, facilitated glucose transporter member 4(SLC2A4),partial

Code CSB-YP021557HU
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Source Yeast
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Code CSB-EP021557HU
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Source E.coli
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Code CSB-EP021557HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP021557HU
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Source Baculovirus
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Code CSB-MP021557HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names SLC2A4
Uniprot No. P14672
Alternative Names insulin-responsive; Glucose transporter GLUT 4; Glucose transporter type 4; Glucose transporter type 4 insulin responsive; GLUT 4; GLUT-4; GLUT4; GTR4_HUMAN; Insulin responsive glucose transporter type 4; kug; SLC 2A4; SLC2A4; solute carrier family 2 (facilitated glucose transporter) member 4; Solute carrier family 2 member 4; Solute carrier family 2, facilitated glucose transporter member 4
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Insulin-regulated facilitative glucose transporter.
Gene References into Functions
  1. Higher expression of GLUT-4 is associated with Oral Epithelial Dysplasia compared to Oral Squamous Cell Carcinoma. PMID: 30049187
  2. Adipose tissue sirtuin 1 was related to insulin sensitivity. The relationship was still present after controlling for BMI, however, it disappeared after controlling for adipose tissue SLC2A4. Muscle sirtuin 1 was not related to insulin sensitivity. PMID: 29417372
  3. Results showed that GLUT4 translocation is regulated by TBC1D15 affecting glucose uptake. PMID: 30316925
  4. This review will summarize the effects of phytochemicals and their action on insulin signaling pathways accelerating GLUT4 translocation based on the current literature. PMID: 29382104
  5. Cell-autonomous adiposity results from increased cell surface GLUT4 due to ankyrin-B deficiency in humans and mice. PMID: 29133412
  6. The authors show that insulin-stimulated Glut4-mediated glucose uptake requires PDPK1 phosphorylation of the kinase domain but not mTORC2 phosphorylation of the hydrophobic domain. Nonetheless, an intact hydrophobic domain is required for Glut4-mediated glucose uptake. PMID: 28589878
  7. rs5435 was not associated with T1D in the Euro-Brazilian population. PMID: 28973736
  8. Three polymorphisms (rs2654185, rs5415, and rs5417) in SLC2A4 were positively correlated with hip circumference and the rs2654185 locus was also positively associated with thigh circumference. Consumption of n-3 polyunsaturated fatty acids modifies associations between SCD, SLC2A4, and SREBF1 polymorphisms and anthropometric variables and metabolic phenotypes. PMID: 27467133
  9. increased GLUT4 expression in oral squamous cell carcinoma patients was significantly associated with a poor overall survival (OS, P = 0.035) and recurrence-free survival (RFS, P = 0.001). Furthermore, the ectopic overexpression of GLUT4 in cell lines with low endogenous GLUT4 expression resulted in a significant increase in migratory ability both in vitro and in vivo PMID: 28061796
  10. our study has found that BMI, hypertension, myometrial invasion, pathological type, and Glut4 positive expression might be prognostic factors of EC [Endometrial cancer ] PMID: 26437953
  11. Our work highlights the convenience and efficiency of this novel pH-sensitive fluorescent probe and reveals the new biological activity of staurosporine as an agonist for GLUT4 translocation and as an effective insulin additive analogue. PMID: 27769857
  12. studies demonstrate that Elmo2 is a new regulator of insulin-dependent Glut4 membrane translocation through modulating Rac1 activity and Akt membrane compartmentalization. PMID: 27226625
  13. This review focuses on recent advances on the role of these signaling pathways and transcription factors involved in the regulation of CD36 and GLUT4. PMID: 27403883
  14. These results suggest that the initial event caused by overnutrition may be oxidative stress, which produces insulin resistance, at least in part, via carbonylation and oxidation-induced inactivation of GLUT4. PMID: 26355033
  15. A single bout of exercise elicited similar GLUT4 translocation in skeletal muscle of PCOS and Controls. The absence of impairment in GLUT4 translocation suggests that PCOS patients with obesity and insulin resistance may benefit from exercise training. PMID: 26373822
  16. SLC2A4 gene expression level was slightly lower within type 2 diabetic patients in both type of tissues. Furthermore, the negative correlation between SLC2A4 gene expression level in visceral adipose tissue and BMI has been noticed PMID: 26529385
  17. GIV directly and constitutively binds the exocyst complex subunit Exo-70 and also associates with GLUT4-storage vesicles (GSVs) exclusively upon insulin stimulation. PMID: 26514725
  18. Data suggest that down-regulation of GLUT4 expression in white/beige/brown adipocytes is associated with impaired glucose uptake/metabolism, impaired adipogenesis, and insulin resistance. [REVIEW] PMID: 25703677
  19. Study of the molecular mechanisms of GLUT4 regulation in adipocytes. PMID: 24656589
  20. These results indicate that T2DM patients may have a high level miR-199a that reduce GLUT4 expression and contribute to the insulin resistance. PMID: 25084986
  21. Role of the guanine nucleotide exchange factor in Akt2-mediated plasma membrane translocation of GLUT4 in insulin-stimulated skeletal muscle. PMID: 25025572
  22. Therapeutic concentrations of cyclosporine and tacrolimus can inhibit glucose uptake independent of insulin signaling by removing GLUT4 from the cell surface via an increased rate of endocytosis. PMID: 25004245
  23. shRNA-mediated down-regulation of GLUT4 diminishes glucose uptake and induces metabolic reprogramming by reallocating metabolic flux to oxidative phosphorylation. PMID: 24931902
  24. findings suggest that the AA genotype and A allele of SLC2A4 promoter, rs5418 were associated with top-level endurance performance in the northern Han Chinese population. PMID: 24533495
  25. Inhibition of PGC-1A suppresses cell proliferation probably by downregulation of VEGF and GLUT-4. PMID: 24402435
  26. GLUT4 gene SNPrs5417 is associated with obstructive sleep apnea syndrome in hypertensive population. PMID: 24410986
  27. Crystal structure of Myo1c/14-3-3beta complex, which has been implicated in the exocytosis of glucose transporter 4 storage vesicles during insulin-stimulated glucose uptake. PMID: 24636949
  28. Taken together, these results demonstrated that BCAR3 plays an important role in the signaling pathways of insulin leading to cell cycle progression and cytoskeleton reorganization, but not GLUT4 translocation. PMID: 24216110
  29. it is clear that pharmacogenomics has great potential to select subjects more or less prone to regulate the SLC2A4 gene and consequently glycemic homeostasis. PMID: 23746177
  30. Insulin-stimulated GLUT4 trafficking differs between t-tubules and sarcolemma; contraction-induced GLUT4 trafficking does not differ between membrane surfaces.[review] PMID: 23072821
  31. Data suggest that 11 weeks of daily moderate- or high-intensity aerobic exercise improves insulin resistance and up-regulates glucose transport and GLUT4 in skeletal muscle (but not in white adipose tissue) of young overweight men. PMID: 23800880
  32. findings showed that adipose insulin-responsive glucose transporter type 4 (GLUT4) gene expression changes were more related to insulin resistance and type 2 diabetes rather than to obesity PMID: 21604201
  33. Data suggest that 17 beta-estradiol enhances the the glucose uptake, activates PI3K/Akt signaling pathway, leading to translocation of glucose transporter 4 to the plasma membrane in an ERalpha-dependent manner. PMID: 23546602
  34. Data from normally cycling young women suggest that expression of GLUT4 in endometrium is higher in follicular phase (as compared to luteal phase) and is localized to epithelial cells (as compared to stromal cells). PMID: 22971162
  35. Insufficient GLUT4 translocation results in decreased glucose supply in patients with critical illness myopathy. PMID: 23239154
  36. HbA1c is significantly higher in the most frequent GA haplotype compared with the second frequent AC haplotype (5.2% vs. 5.1%, P = 0.004). Genetic variations, rs5418 and rs2654185 in GLUT4 gene are associated with HbA1c level in Japanese men. PMID: 22673408
  37. CLASP2 directs the delivery of GLUT4 to cell cortex landing zones important for insulin action PMID: 22992739
  38. These data provide evidence for the existence of GLUT4 in the endocrine pancreas and indicate a physiological relevance of this glucose transporter as well as characteristic changes in diabetic disease. PMID: 22488520
  39. data reveal that T(3) rapidly increases glucose uptake in L6-GLUT4myc cells, which, at least for 30 minutes, did not depend on an increment in GLUT4 at the cell surface yet potentiates insulin action. PMID: 22663547
  40. The role of CaMKII in regulating GLUT4 expression in skeletal muscle. PMID: 22496345
  41. The introduction of beta(2)-adrenoceptors and GLUT4 into these cells caused increased glucose uptake in response to beta-adrenoceptor agonists. PMID: 21883150
  42. GLUT4 translocation and expression is induced by (+)-Rutamarin PMID: 22384078
  43. Both adipose tissues have lower GLUT4 levels in patients with coronary artery disease; these findings suggest a differential regulation of RBP4 production in epicardial adipose tissue and subcutaneous adipose tissue, possibly influenced by local factors. PMID: 21645024
  44. Critical roles for novel GLUT family members highlight a therapeutic strategy entailing selective GLUT inhibition to specifically target aberrant glucose metabolism in cancer. PMID: 22452979
  45. The present findings demonstrate that physical inactivity-induced insulin resistance in muscle is associated with lower content/activity of key proteins in glucose transport/phosphorylation and storage. PMID: 22403297
  46. investigation of mechanisms involved in insulin-stimulated translocation of GLUT4 from intracellular sites to sarcolemma; studies involve glucose metabolism in transgenic mice expressing a GLUT4 fusion protein (HA-GLUT4-GFP) in skeletal muscle/heart PMID: 22297303
  47. GLUT4 protein expression is reduced in muscle from type 2 diabetic patients with severe insulin resistance. PMID: 22114711
  48. genetic association studies of GLUT4 in a population in India: An SNP in GLUT4 (rs5435, C/T) is associated with type 2 diabetes. ACGT haplotypes of rs5418 (A/G), rs5435 (C/T), rs5421 (C/G), and T/G variant in 3-UTR showed protection against diabetes. PMID: 21668369
  49. insulin resistance is observed in patients with advanced liver cirrhosis but may not be correlated with the skeletal contents of GLUT4 protein and mRNA PMID: 21796809
  50. critical roles of the N-glycan chain in quality control as well as intracellular trafficking of GLUT4. PMID: 21757715

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Involvement in disease Diabetes mellitus, non-insulin-dependent (NIDDM)
Subcellular Location Cell membrane, Multi-pass membrane protein, Endomembrane system, Multi-pass membrane protein, Cytoplasm, perinuclear region
Protein Families Major facilitator superfamily, Sugar transporter (TC 2.A.1.1) family, Glucose transporter subfamily
Tissue Specificity Skeletal and cardiac muscles; brown and white fat.
Database Links

HGNC: 11009

OMIM: 125853

KEGG: hsa:6517

STRING: 9606.ENSP00000320935

UniGene: Hs.380691

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