Recombinant Human Sushi domain-containing protein 2 (SUSD2), partial

Code CSB-YP866225HU
MSDS
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Source Yeast
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Code CSB-EP866225HU
MSDS
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Source E.coli
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Code CSB-EP866225HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP866225HU
MSDS
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Source Baculovirus
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Code CSB-MP866225HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
SUSD2
Uniprot No.
Alternative Names
1200011D11Rik; BK65A6.2; FLJ22778; SUSD2; SUSD2_HUMAN; Sushi domain-containing protein 2
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest. May play a role in breast tumorigenesis.
Gene References into Functions
  1. platelet activation and binding to high-grade serous ovarian carcinoma cells was inversely correlated with the presence of SUSD2. This represents one of the first tumor proteins known to provide differential platelet interaction based on protein status. PMID: 30335544
  2. suggest that SUSD2 counteracts senescence and cell death and is thus a potential chemotherapeutic target in human endometrial cancer PMID: 28841682
  3. Tumors with high levels of SUSD2 staining contained 2-fold more tumor-associated macrophages, mainly of the M2 pro-angiogenic phenotype PMID: 28475599
  4. Low SUSD2 expression is associated with renal cell carcinoma and lung cancer. PMID: 26815503
  5. No evidence of association between polymorphisms in SUSD2 and sporadic amyotrophic lateral sclerosis in Han Chinese PMID: 25677198
  6. Authors found significantly fewer CD4 tumor infiltrating lymphocytes in breast tumors expressing Susd2. PMID: 23131994
  7. Two new susceptibility loci for amyotrophic lateral sclerosis in the Han Chinese population in chromosome 1, CAMK1G and chromosome 22, SUSD2 and CABIN1. PMID: 23624525

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Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity
Highly expressed in breast cancer, but shows a restricted expression pattern in normal tissues such as adipose, adrenal gland, kidney, lung, mammary gland, placenta, thyroid, trachea, and uterus. Also expressed in colon; down-regulated in colon cancer tis
Database Links

HGNC: 30667

OMIM: 615825

KEGG: hsa:56241

STRING: 9606.ENSP00000351075

UniGene: Hs.131819

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