Recombinant Human Syntaxin-binding protein 1(STXBP1)

Code CSB-MP022905HU
Product Type Recombinant Protein
Size US$1848
Uniprot No. P61764
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Purity >85% (SDS-PAGE)
Sequence MAPIGLKAVVGEKIMHDVIKKVKKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGITIVEDINKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAAHVFFTDSCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPILERLAEQIATLCATLKEYPAVRYRGEYKDNALLAQLIQDKLDAYKADDPTMGEGPDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVYKYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSSKRMNTGEKTTMRDLSQMLKKMPQYQKELSKYSTHLHLAEDCMKHYQGTVDKLCRVEQDLAMGTDAEGEKIKDPMRAIVPILLDANVSTYDKIRIILLYIFLKNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPIVTDSTLRRRSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRSSASFSTTAVSARYGHWHKNKAPGEYRSGPRLIIFILGGVSLNEMRCAYEVTQANGKWEVLIGSTHILTPQKLLDTLKKLNKTDEEISS
Research Area Cancer
Source Mammalian cell
Gene Names STXBP1
Protein Names Recommended name: Syntaxin-binding protein 1Alternative name(s): MUNC18-1 N-Sec1 Protein unc-18 homolog 1 Short name= Unc18-1 Protein unc-18 homolog A Short name= Unc-18A p67
Expression Region 1-594aa
Tag Info N-terminal 6xHis-tagged
Mol. Weight 68.6
Protein Description Full Length
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1
Involvement in disease Epileptic encephalopathy, early infantile, 4 (EIEE4)
Subcellular Location Cytoplasm, cytosol, Membrane, Peripheral membrane protein
Protein Families STXBP/unc-18/SEC1 family
Tissue Specificity Brain and spinal cord. Highly enriched in axons.
Database Links

HGNC: 11444

OMIM: 602926

KEGG: hsa:6812

STRING: 9606.ENSP00000362399

UniGene: Hs.288229

Pathway Synaptic vesicle cycle

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