Recombinant Human Transcription factor AP-2 gamma (TFAP2C)

1. Study discovered a novel enhancer HER2 gene body enhancer (HGE) in the 3' gene body of HER2. The HGE activates promoters 1 and 2 in trans., and hence the TFAP2C-mediated transcriptional induction of HER2 expression in breast cancer samples. PMID: 29035388
2. This study shows that TFAP2C promoted lung tumor progression by upregulation of TGFBR1 and consequent activation of PAK1 signaling. PMID: 27885255
3. miR-137 is a Slug-induced miRNA that relays the pro-metastatic effects of Slug by targeting TFAP2C in non-small cell lung cancer cells. PMID: 28610956
4. TFAP2C might increase oncogenic miR-183 expression and consequently downregulate tumor-suppressive AKAP12 and decrease tumor-suppressive miR-33a expression and subsequently induce CDK6 in NSCLC cells. PMID: 27593936
5. Higher TFAP2C protein expression correlates with poor overall survival after 10 years of diagnosis in ERalpha-positive breast cancer. PMID: 26160249
6. In all three groups[preeclamptic placentas , healthy control and smokers] expression rates of AP-2gamma did not differ between primary, secondary and tertiary villi. PMID: 25315380
7. TFAP2C has an important role in regulated luminal-specific genes and may be a viable therapeutic target in breast cancer. PMID: 24469049
8. ShRNA knockdown of AP-2gamma in neuroblastoma cells results in significant inhibit of cell proliferation. PMID: 24969902
9. Knockdown of TFAP2C or RET inhibited activation of ERK and AKT in MCF-7 cells. Knockdown of TFAP2C, which controls ER (estrogen receptor) and RET, had a greater effect on cell growth than either RET or ER alone. PMID: 24045439
10. role for TFAP2C in melanoma via its regulation of ECM1 PMID: 24023917
11. TFAP2C amplification and overexpression represents a genetic dependency in ERBB2+ve breast cancer. PMID: 23334330
12. TFAP2C regulates expression of the RET proto-oncogene through five AP-2 regulatory sites in the RET promoter. PMID: 22878616
13. Results demonstrate that TFAP2C regulates the expression of GPX1, which influences the redox state and sensitivity to oxidative stress induced by peroxides. PMID: 22964634
14. results substantiate a role for Tcfap2c/ TFAP2C in supporting proliferation and repressing differentiation in cellular compartments representing immature/ progenitor cells.[review] PMID: 22560121
15. We demonstrated that TFAP-2gamma is one of the transcription factors involved in the HuPAR-2 expression in human villous trophoblast cells. PMID: 22702469
16. demonstrated that while TFAP2C and Myc can downregulate the CDKN1A promoter independently, KDM5B acts as a corepressor dependent on the other two proteins PMID: 22371483
17. AP-2gamma is a novel collaborative factor in ERalpha-mediated transcription. PMID: 21572391
18. miR-214 is highly expressed in human melanomas and the data suggest a critical role for this miRNA in disease progression and the establishment of distant metastases through suppression of TFAP2C. PMID: 21468029
19. Overexpression of TFAP2C is associated with hormone responsive breast carcinoma. PMID: 20629094
20. AP-2 gamma and Dlx 3, together with an additional transcription factor(s) that are conserved between humans and mice, are required for trophoblast-specific expression of 3 beta-HSD VI. PMID: 11773066
21. AP-2gamma is important in regulation of ErbB-3 expression in human mammary epithelial and lung fibroblast cells PMID: 11859873
22. we have identified a potential trophoblast cell-specific regulatory element located 6 kb upstream of the murine AP-2gamma gene transcription start site, and that Sp1 and Sp3 bind to cis-regulatory elements located in the promoter proximal region PMID: 12801994
23. AP-2gamma expression in breast cancer cells is induced by oestrogens through binding of the oestrogen receptor to a response element within the 5'-untranslated region. PMID: 14565844
24. Abundant expression of AP-2gamma is associated with intratubular germ cell neoplasias PMID: 15700319
25. Expression microarray results in human breast carcinoma cells with forced p53 expression revealed AP-2gamma as a putative transcriptional target of p53. PMID: 16636674
26. TFAP2C is the key regulator of hormone responsiveness in breast carcinoma cells through the control of multiple pathways of estrogen signaling. TFAP2C regulates the expression of ERalpha directly by binding to the ERalpha promoter. PMID: 17875680
27. Wwox and Ap2gamma emerge are tumor biomarkers that may be superior to PR and Her2 in predicting tamoxifen response PMID: 17947476
28. AP2 transcription factors may play decisive pacemaker roles in initiating and coordinating budding and branching processes during formation of the fetal breast anlage PMID: 18042070
29. Down-modulation of AP-2gamma expression in tumor cells by RNA interference led to enhanced tumor growth and reduced chemotherapy-induced cell death, as well as migration and invasion. PMID: 18443366
30. Reduced expression levels of nuclear AP2gamma is associated with the pathogenesis of basal-like differentiation in breast cancer. PMID: 19130459
31. Data show that the combination of increasing chromatin accessibility and inducing TFAP2C provides a more robust activation of the ERalpha gene in ERalpha-negative breast cancer cells. PMID: 19458056
32. ErbB2, CDH2, HPSE and IGSF11 are identified as AP-2gamma target genes in breast cancer cells. PMID: 19671168
33. AP-2gamma promotes proliferation in breast tumour cells by direct repression of the CDKN1A gene. PMID: 19798054

Show More

Hide All

HGNC: 11744

OMIM: 601602

KEGG: hsa:7022

STRING: 9606.ENSP00000201031

UniGene: Hs.473152