Recombinant Human Transcription factor GATA-6 (GATA6)

1. The long non-coding antisense transcript of GATA6 (GATA6-AS) interacts with the epigenetic regulator LOXL2 to regulate endothelial gene expression via changes in histone methylation. A number of angiogenesis- and hypoxia-related genes were downregulated by GATA6-AS silencing. PMID: 29339785
2. High GATA6 expression is associated with Gastric Cancer. PMID: 29321084
3. Increased GATA6 expression is associated with laryngeal squamous cell carcinoma. PMID: 29517349
4. These findings suggest that GATA6 might interact with HNF4alpha and contribute to the development of mucinous-type lung adenocarcinomas PMID: 29469192
5. Genetic variants in GATA6 gene had severe pancreatic atrophy but with abundant beta cells and severe amyloidosis similar to type 2 diabetes. PMID: 28938416
6. Study firstly associates GATA6 loss-of-function mutation with increased susceptibility to familial congenital bicuspid aortic valve (BAV) in humans, which provides novel insight into the molecular pathogenesis underlying BAV. PMID: 29653232
7. loss of one GATA6 allele affects the differentiation of pancreatic progenitors from the early PDX1+ stage to the more mature PDX1+NKX6.1+ stage, leading to impaired formation of glucose-responsive beta-like cells; in addition to this GATA6 haploinsufficiency, also identified dosage-sensitive requirements for GATA6 and GATA4 in the formation of both definitive endoderm and pancreatic progenitor cells PMID: 28196600
8. Results show that GATA6 protein levels are reduced in tissue samples from colon cancer patients with miR-196b upregulation and that GATA6 is a direct target of miR-196b. PMID: 27902469
9. Our data suggested that miR-124 decreases GATA6 expression by targeting its 3'-UTR, which in turn inhibits cholangiocarcinoma invasion and metastasis. PMID: 28270130
10. Gain-of-function mutations in GATA6 in both a family with early-onset Atrial Fibrillation and Atrioventricular Septal Defects was found. PMID: 27756709
11. analysis of the TNF-insulin signaling with GATA6 reveals specific patterns of gene expression in cells receiving multiple stimuli PMID: 27273097
12. These data show that GATA6 plays a critical role in endoderm and pancreas specification and beta-like cell functionality in humans. PMID: 28196690
13. GATA6 variant frequency in sporadic CTDs patients was higher than that in other congenital heart diseases. PMID: 29101065
14. Knockdown of GATA6 completely eliminated the effect of TCF1, while forced expression of GATA6 induced hESC differentiation PMID: 28943339
15. In human Pancreatic Ductal Adenocarcinoma cells, GATA6 inhibits de-differentiation and epithelial-mesenchymal transition both directly and indirectly, through mechanism that involves the regulation of transcription factors, including FOXA1/2.Loss of GATA6 in PDAC primary samples is associated with altered differentiation and shorter overall patient survival. PMID: 27325420
16. GATA6 induces expression of genes essential for growth of colon cancer cells under adherent conditions (REG4) and genes required for their clonogenicity (LGR5), and miR-363-GATA6-REG4/LGR5 signaling cascade promotes tumorigenicity of colon cancer cells. PMID: 26387746
17. In the pancreas, Gata6 acts as a tumour suppressor by enforcing acinar cell differentiation, by directly and indirectly repressing ectopic differentiation programmes, and by regulating crucial cancer-related gene expression pathways. PMID: 25596178
18. Our results, for the first time, portray a pivotal role of GATA6 in regulating metastatic behaviors of breast cancer cells PMID: 26505174
19. miR-181b was upregulated by hypoxia in retinoblastoma in an HIF-1a-independent manner. Additionally, miR-181b exerts its angiogenic function, at least in part, by inhibiting PDCD10 and GATA6. PMID: 25872572
20. data indicated that GATA-6 and Akt2 are involved in the mTORC1-mediated regulation of VSMC proliferation and differentiation. PMID: 25969542
21. results show how genetic mutations in GATA6 may lead to functional inactivity and pancreatic agenesis in humans PMID: 25706805
22. GATA6 expression is progressively increased during Barrett's oesophagus development and its malignant transformation to esophageal adenocarcinoma. PMID: 25445407
23. association of GATA6 loss-of-function mutations with enhanced susceptibility to familial dilated cardiomyopathy PMID: 25119427
24. These results establish SHP as a novel antihypertrophic regulator that acts by interfering with GATA6 signaling. PMID: 25015078
25. SNPs within the GATA6 gene promoter identified in ventricular septal defects patients may change GATA6 levels, contributing to the VSD development as a risk factor. PMID: 25036032
26. Three heterozygous missense mutationsof GATA-binding factor 6, c.151G>A (E51K), c.551G>A (S184N) and c.733G>C (G245R), were identified in patients with tetralogy of Fallot or persistent truncus arteriosus. PMID: 24841381
27. analysis of the GATA6 transcriptional regulation in gastric cancer PMID: 24317510
28. The results show that de novo mutations in GATA6 contribute to the development of congenital diaphragmatic hernia. PMID: 24385578
29. Data suggest that levels of GATA6 in subcapsular zone of adrenal glands (zona glomerulosa) are not prominently different in subjects with primary aldosteronism, subjects with aldosterone-producing adrenocortical adenomas, or normal subjects. PMID: 24531914
30. Based on the data presented in this paper, we conclude that the heterozygous nonsense mutation, p.Arg493X of GATA6 resulted in pancreatic agenesis and congenital heart defects. PMID: 24310933
31. DNA sequence variants within the GATA6 gene promoter may contribute to the IIH development as a risk factor by changing the GATA6 levels PMID: 24949533
32. GATA6 overexpression is associated with hepatic metastasis of colorectal cancer. PMID: 23784465
33. FOG1, FOG2 and GATA-6 modulate the transcriptional up-regulation of HAMP in hepatocytes during inflammation. PMID: 24179092
34. Spontaneously differentiated GATA6-expressed human embryonic stem cells represent an important cellular step in human embryonic development. PMID: 23746070
35. Our 2 cases with novel GATA6 mutations add more phenotype characteristics of GATA6 haploinsufficiency PMID: 23635550
36. Endothelial GATA-6 plays a critical role in the molecular mechanisms underlying endothelial cell dysfunction in pulmonary arterial hypertension. PMID: 23583651
37. Novel mutations identified in the GATA6 gene are associated with tetralogy of Fallot. PMID: 23158662
38. GATA6 and HOPX are critical nodes in a lineage-selective pathway that directly links effectors of airway epithelial specification to the inhibition of metastasis in the lung ADC subtype. PMID: 23707782
39. Data suggest that GATA6 was an independent prognostic marker for overall survival and recurrence-free survival in cholangiocarcinoma (CCA). PMID: 23313142
40. GATA6 mutation was identified in a patient with atrial fibrillation and co-segregated with the disease as an autosomal dominant trait in the family. PMID: 22750565
41. Results imply that miRNA-145 indirectly targets BMP4 via GATA6 and is potentially involved in the development of Barrett Esophagus (BE). PMID: 22504665
42. A novel heterozygous GATA6 mutation, p.G469V, was identified in a family with atrial fibrillation inherited in an autosomal dominant pattern. PMID: 22824924
43. This is the first report on the association of somatic GATA6 loss-of-function mutation with increased susceptibility to Tetralogy of Fallot. PMID: 23175051
44. mutation screening in 171 subjects with neonatal diabetes of unknown genetic etiology: Data suggest that GATA6 mutations account for a wide spectrum of neonatal diabetes; GATA6 mutations appear to be the major cause of pancreatic agenesis. PMID: 23223019
45. The study characterized the CPI-17 promoter and identified binding sites for GATA-6 and nuclear factor kappa B (NF-kappaB). PMID: 23275439
46. Dominantly inherited diabetes mellitus caused by GATA6 haploinsufficiency. PMID: 22962692
47. GATA6 inactivating mutations are associated with heart defects and, inconsistently, with pancreatic agenesis and diabetes. PMID: 22806356
48. Data indicate that two novel heterozygous GATA6 mutations, p.D404Y and p.E460X, were identified in two families with ventricular septal defect and tetralogy of Fallot, respectively. PMID: 23020118
49. High methylation frequency of tested genes shows heterogeneity of glioblastoma epigenome and the importance of MGMT, GATA6 and CASP8 genes methylation in glioblastoma patient outcome. PMID: 22672670
50. The entire coding region of the GATA6 gene, which encodes a zinc-finger transcription factor crucial to normal cardiogenesis, was sequenced in 130 unrelated patients with congenital ventricular septal defect. PMID: 22407241

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HGNC: 4174

OMIM: 187500

KEGG: hsa:2627

STRING: 9606.ENSP00000269216

UniGene: Hs.514746