Recombinant Human Transcription factor SOX-18 (SOX18)

1. results suggest that SOX18 is overexpressed in Osteosaroma (OS) and plays an important role in proliferation, apoptosis, migration and invasion of OS cells, and may provide a novel and promising thera-peutic strategy for OS. PMID: 29266413
2. The present data demonstrate that the endothelial-specific and lymph endothelial-specific transcription factors SOX18 and PROX1 contribute to lymph endothelial cells retraction PMID: 29749465
3. A novel mutation in the SOX18 gene identified in a patient with hypotrichosis-lymphedema-telangiectasia syndrome. PMID: 29307792
4. Results showed that on the contrary of the mRNA level, the protein levels of SOX18 were higher in lung adenocarcinoma (AC) cases compared to levels noted in the non-malignant lung tissues (NMLTs). The disparity between the mRNA and protein levels of the SOX18 transcription factor was caused by miR-7a and miR-24-3p, although the mechanism through which lung cancer cells downregulate miRNA molecule levels is still unclear. PMID: 29115529
5. miR-7-5p targeted SOX18 to inhibit gp130/JAK2/STAT3 signaling pathway to exert its suppressing role in Pancreatic ductal adenocarcinoma PMID: 29408481
6. Nuclear expression of SOX18 was shown in vascular endothelial cells, basal layer cells of NS epidermis, as well as in AK, BCC and SCC cancer cells PMID: 27127146
7. SOX18 plays a significant role in promoting the growth of pancreatic ductal adenocarcinoma, and might serve as a promising target for PDAC therapy PMID: 27663663
8. Study reports SOX18 as novel risk gene for Neural tube defects (NTDs) but findings also suggest that SOX18 hypomethylation and increased expression must interplay with other environmental and (epi)genetic factors that are causative for NTDs. PMID: 27757173
9. SOX18 was overexpressed in prostate cancer.SOX18 promotes prostate cancer progression via the regulation of TCF1, c-Myc, cyclin D1 and MMP-7. PMID: 27922675
10. the results of this study suggest that knockdown of SOX18 inhibits breast cancer cell growth and invasion, possibly by downregulating downstream oncogenic proteins, providing novel insights into the development of breast cancer therapy through targeting of SOX18. PMID: 27108946
11. miRNAs interact with the mRNA of the SOX18 gene, but the mechanism by which they could be inhibited in cancer cells requires further examination PMID: 27666488
12. The downregulation of SOX18 was found to significantly inhibit cell adhesion and invasion. PMID: 26573263
13. NKD2 inhibits SOX18 and MMP-2,7,9 expression and suppresses BGC823 cell xenograft growth. NKD2 methylation may serve as a poor prognostic and chemo-sensitive marker in human gastric cancer. NKD2 impedes gastric cancer metastasis by inhibiting SOX18. PMID: 26396173
14. GLI1 and GLI2, but not GLI3 are involved in the regulation of SOX18 gene expression in cervical carcinoma cell lines. PMID: 26588701
15. we demonstrated that upregulation of SOX18 was associated with a poor outcome in hepatocellular carcinoma patients PMID: 26151573
16. The genetic finding of a pathogenic SOX18 mutation enabled the diagnosis of the rare hypotrichosis-lymphedema-telangiectasia syndrome in our patient. PMID: 26148450
17. A new, autosomal dominant condition combining hypotrichosis-lymphedema-telangiectasia syndrome with renal defects is associated with a novel truncating mutation in the SOX18 gene. PMID: 24697860
18. SOX18 may be involved in the progression of Non small cell lung cancer. PMID: 25310193
19. SOX18wt has potent trans-activation proper- ties, while SOX18DN displayed dominant-negative effect. PMID: 24460943
20. Data suggest that SOX18 transcription factor expression may serve as a marker for a poor prognosis in invasive ductal breast carcinoma. PMID: 24065215
21. The repression of Sox18 and its target genes may lead to altered formation of vessels in inflamed settings. PMID: 24269235
22. of the 679 gastric cancer cases, 177 (26.1%) were positive for SOX 18 expression in their tumor stroma, and the frequencies of both lymphovascular invasion and lymph node metastases were higher in the SOX 18 positive than in the negative group. PMID: 21796627
23. The identification of MMP7 as a direct SOX18 target gene as well as other potential candidates including guidance molecules provides a molecular basis for the proposed function of this transcription factor in the regulation of vessel formation. PMID: 22292085
24. Heterogeneous methylation in the promoter region of SOX18 was associated with cancer progression in non-small cell lung cancer. PMID: 22018271
25. Mutations in SOX18 underlie recessive and dominat forms of hypertrichosis-lymphedema- telangiectasis/ PMID: 12740761
26. SOX18 is involved in vascular cell growth and this transcription factor may play a role in atherosclerosis PMID: 16179596
27. Overexpression of wild-type SOX18 promoted capillary tube formation of HUVECs in vitro, whereas expression of dominant-negative SOX18 impaired tube formation of HUVECs and the migration of MCF-7 cells via the disruption of the actin cytoskeleton. PMID: 16882943
28. an obligatory role for SOX-18 in the regulation of claudin-5 gene expression in an endothelial-specific and cell density-dependent manner is established PMID: 18065521
29. Transcription factors Sp3, ZBP-89 and NF-Y are capable of binding to the SOX18 promoter region. PMID: 18496767

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HGNC: 11194

OMIM: 137940

KEGG: hsa:54345

STRING: 9606.ENSP00000341815

UniGene: Hs.8619