Recombinant Human Transcriptional enhancer factor TEF-4 (TEAD2), partial

The recombinant Human TEAD2 was expressed with the amino acid range of 94-447. This TEAD2 protein is expected to have a theoretical molecular weight of 47.0 kDa. This protein is generated in a e.coli-based system. The TEAD2 coding gene included the N-terminal 10xHis tag and C-terminal Myc tag, which simplifies the detection and purification processes of the recombinant TEAD2 protein in following stages of expression and purification.

The human transcriptional enhancer factor TEF-4, also known as TEAD2, is a member of the TEAD family of transcription factors. TEAD2 plays a crucial role in the regulation of gene expression by binding to the MCAT element (Muscle CAT box), a common cis-regulatory element found in muscle-specific genes. TEAD2 is involved in various biological processes, including embryonic development, cell proliferation, and tissue homeostasis. It acts as a transcriptional coactivator and interacts with different transcription factors, such as Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), forming complexes that modulate gene expression. TEAD2's involvement in the Hippo signaling pathway underscores its significance in development, organ size control, and cancer progression. Understanding TEAD2's functions is crucial for unraveling its contributions to normal physiological processes and disease states.