Recombinant Human Transketolase-like protein 1 (TKTL1)

1. The results obtained in this study suggest that pentose phosphate pathway and its key enzyme TKTL1 is altered throughout the prostate cancer tumorigenesis PMID: 30119993
2. Inhibition of TKTL1 expression reverses paclitaxel resistance in human ovarian cancer cells and reduces cell proliferation. PMID: 29885837
3. The research provides evidence that TKTL1 renders tumor cells more resistant to radiation therapy and to hypoxic conditions. PMID: 30044385
4. Knockdown of TKTL1 additively complements cisplatin-induced cytotoxicity in the nasopharyngeal carcinoma cells by inhibiting the levels of NADPH and ribose-5-phosphate, indicating that TKTL1 may be a promising target to improve the therapeutic effect combining with cisplatin for the patients with nasopharyngeal carcinoma. PMID: 27916418
5. We show that high TKTL1 in tumor tissue can lead to poor survival in colorectal cancer. TKTL1 thus can serve as a candidate marker for identifying patients at risk of recurrent disease PMID: 26650256
6. Data provide evidence for an important role of TKTL1 in aerobic glycolysis and tumor promotion in melanoma that may result from defective promoter methylation. PMID: 26907172
7. the cytoplasmatic expression of TKTL1 is specific for MIBC tissue compared with histopathologically benign urothelium. PMID: 25572961
8. Both TKTL1 and p63 are independent prognostic factors of the poor outcome of gastric cancer patients PMID: 26406948
9. TKTL1 is associated with a more aggressive behavior in human esophageal squamous cell carcinoma cells PMID: 26349965
10. Data revealed exceptional occurrence of TKTL1 in a panel of malignant human cell lines in vitro suggesting that its presence was unrelated to either the rate of glucose consumption/lactic acid production or resistance against chemo- and radiotherapy. PMID: 26187043
11. our results suggest that TKTL1 as a key prognostic factor may be a novel target for therapy of the patients with esophageal squamous cell carcinoma. PMID: 26032094
12. In 50% of colorectal cancer patients, TKTL1 protein expression was upregulated in tumor compared to non-tumor tissue. TKTL1 expression correlated with HIF-1alpha protein expression and was induced upon hypoxic conditions. PMID: 24193262
13. TKTL1 expression levels appear to decline in the course of CML with lowest levels during blast crisis. A potential reason is a shift of TKTL1-high-expressing mature granulocytes towards TKTL1-low-expressing immature cells and blasts. PMID: 24390277
14. DNASEX and TKTL1 detection in patient blood is associated with poor disease-free survival rate in oral squamous cell carcinoma. PMID: 24304513
15. EDIM-TKTL1 blood test revealed good concordance with FDG-PET/CT results in patients with malignancies demonstrating its efficacy to detect upregulation of glucose metabolism in primary tumors or metastases. PMID: 23130932
16. Data indicate that transketolase (hTKT). shares 61% sequence identity with transketolase-like protein (TKTL1). PMID: 23261987
17. No transketolase activity of TKTDelta38 can be detected for conversion of physiological sugar substrates thus arguing against an intrinsically encoded enzymatic function of TKTL1 in tumor cell metabolism PMID: 23118983
18. TKLT1 is devoid of two critical histidine residues that are conserved in other TK. PMID: 22803947
19. TKTL1 is dysregulated in malignant tumors of the ocular adnexa, and enhanced expression seems to predict clinical outcome, especially the tumor recurrence rate. PMID: 22658715
20. TKTL1 could be a target protein for improved therapeutic strategies in some cases of lung cancer. PMID: 22445516
21. TKTL1 overexpression is a new and independent predictor of survival for patients with non-small cell lung cancer PMID: 22027741
22. Investigated the expression of VEGFR-1, VEGFR-2 and TKTL1 in patients with LARC treated with neoadjuvant chemoradiotherapy and cetuximab. High TKTL1 expression significantly correlated with disease free survival. PMID: 21854597
23. correlation of TKTL expression with tumor stage, probability of tumor recurrence and survival in colorectal cancer PMID: 21980427
24. Single Nucleotide Polymorphism in TKTL1 is associated with diabetic nephropathy. PMID: 20826743
25. LDH5 is overexpressed in non-small cell lung cancer and could serve as a marker for malignancy. LDH5 correlates positively with the prognostic marker transketolase like 1 protein. PMID: 20385008
26. Transketolase-like protein 1 confers resistance to serum withdrawal in vitro. PMID: 20884117
27. Overexpression of TKTL1 is associated with gastric cancer. PMID: 20200485
28. TKTL1 does not regulate glucose metabolism in malignant cells. PMID: 20596653
29. transketolase-like 1 protein (TKTL1) is expressed in human endometrial cancer PMID: 20592357
30. TKTL1 is a novel candidate oncogene that is epigenetically activated by aberrant hypomethlation and contributes to a malignant phenotype through altered glycolytic metabolism and HIF1alpha accumulation. PMID: 20103683
31. Expression of pAkt, GLUT1 and TKTL1 were higher in breast cancer and DCIS than in normal tissue. PMID: 19655166
32. demonstrate the presence of a second transketolase enzyme (TKTL1) in humans. This protein and its mutations and clinical implications are characterized. PMID: 15991799
33. Findings strongly indicate that overexpression of TKTL1 is responsible for observed tumor-specific effects of transketolase enzyme reactions PMID: 16465194
34. TKTL1 upregulation is a common phenomenon in gastric cancer and cancer of the gastroesophageal junction leading to an enhanced, oxygen-independent glucose usage which might contribute to a more aggressive tumor growth PMID: 16969476
35. These results indicate that TKTL1 gene influences total transketolase activity and cell proliferation in human hepatoma cells. PMID: 17321041
36. Transketolase, but not G6PD activity, was more elevated in metastasizing tumors and TKTL1 protein was significantly overexpressed in progressing tumors (p = 0.03). PMID: 18302154
37. expression of transketolase-like enzyme 1 was found in 81% of granulosa cell tumors of the ovary PMID: 18394773
38. Compared with grades II and III astrocytic gliomas, glioblastoma multiformes showed higher expression of TKTL1, more positive tumors, and a higher percentage of positive tumor cells. PMID: 18550470
39. findings suggest that tktl1 overexpression in thyroid carcinoma is a factor which facilitates tumor growth and progression PMID: 18615628
40. results suggest that both Transketolase-like enzyme 1 (TKTL1) and p-Akt protein play an important role in the progression of cervical neoplasia PMID: 18686341
41. TKTL1 overexpression may be considered not only as a new tumor marker but also as a good target for anticancer therapy. PMID: 19065656
42. TKTL1 plays an important role in total transketolase activity and cells proliferation in uterine cervix cancer PMID: 19331662
43. RNAi-mediated suppression of TKTL1 in hepatoma cells significantly reduces total transketolase activity and inhibits proliferation. Findings suggest that TKTL1 plays an important role in glycometabolism and cell cycle progression in tumors. PMID: 17321041

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HGNC: 11835

OMIM: 300044

KEGG: hsa:8277

STRING: 9606.ENSP00000358931

UniGene: Hs.102866