Recombinant Human Tryptase alpha/beta-1 (TPSAB1)

1. Basal serum tryptase in children with actual drug hypersensitivity is not a risk factor for severe systemic reactions PMID: 27288661
2. Increased TPSAB1 copy number is associated with multisystem disorder. PMID: 27749843
3. this study shows that active cow's milk-induced enterocolitis syndrome children have higher serum tryptase levels compared to resolved disease PMID: 27545065
4. sBT levels may have a potential use in supporting a diagnosis of asthma in children and as a predictor of disease severity. PMID: 28049209
5. CD3 showed a positive correlation with tryptase and microvascular density, while multiple regression analysis efficaciously predicted microvascular density depending on CD3 and tryptase as predictors, supporting a complex interplay between these cells in sustaining tumor angiogenesis in Diffuse large B cell lymphoma patients. PMID: 25957593
6. We found the determination of serum tryptase levels over time to be a reassuring correlate of clinical improvement in pediatric mastocytosis PMID: 26044856
7. genetic polymorphism is associated with Dengue Hemorrhagic Fever and Dengue Shock Syndrome in Vietnam and Philippines PMID: 25797204
8. Elevated serum tryptase and ET-1 may be markers of increased coronary instability; some cytokines may be related to the extension of CAD. PMID: 26089601
9. these data suggest that the expression of tryptase is regulated by SCF/C-KIT signaling via the ERK1/2 and p38MAPK pathways. PMID: 24806698
10. Urine tryptase beta was increased in patients with chronic prostatitis/chronic pelvic pain syndrome compared to controls. PMID: 24726923
11. Results demonstrated serum tryptase levels in colo-rectal cancer (CRC) patients before radical surgical resection. PMID: 24915568
12. Circulating tryptase level is associated to obesity related parameters and has a close relation with various metabolic risk factors for subclinical atherosclerosis PMID: 24830464
13. Alpha-tryptase gene variation is associated with levels of circulating IgE and lung function in asthma. PMID: 24372627
14. The best criterion for discriminating IgE- and non IgE-mediated hypersensitivity reactions in anaesthesia was a tryptase value exceeding twice the basal one. PMID: 24237068
15. With elevated tryptase level, a history of hornet sting-triggered anaphylaxis, and venom-specific IgE, a patient is at increased risk of severe life-threatening anaphylactic response to a future sting, as well as for having underlying clonal mastocytosis. PMID: 24565497
16. Monitoring of serum baseline tryptase in indolent systemic mastocytosis patients is closely associated with poor prognosis disease features as well as with disease progression. PMID: 24155887
17. The accumulated data in this review suggest that mast cells and their tryptases and chymases play important roles in tissue repair. PMID: 24507159
18. The high density of tryptase(+) Mmast cells at invasive margins of tumours was associated with advanced stages of colorectal cancer and was strongly correlated with PAR-2 expression. PMID: 23991686
19. As much as 82% of the variation in serum tryptase is due to genetics factors, and genetic effects overlap serum tryptase and body mass index. PMID: 24054365
20. The identification of an abundant population of tryptase(+)/Nanog(+) cells in infantile haemangioma is novel. PMID: 23559352
21. Our results indicate that sBT levels are associated with a higher risk of severe SR in children with insect venom hypersensitivity. PMID: 23330964
22. Tryptase is a biomarker related to the severity of anaphylaxis. PMID: 23018683
23. results suggest that tryptase can induce microglia activation and pro-inflammatory mediator release via PAR-2-MAPK-NF-kappa B signaling pathway, which will contribute to the development of microglia-mediated inflammation in brain PMID: 22613992
24. Both IgE and chymase associate with diabetes status. PMID: 22194960
25. As mast cells are an important source of VEGF, tryptase, and chymase, these findings suggest that mast cell activation and mast cell-derived mediators participate in the development of Dengue hemorrhagic fever. PMID: 22363824
26. Mast cell tryptase stimulates production of decorin by human testicular peritubular cells PMID: 21791437
27. Two different populations of mast cells were found in melanocytic skin; one expressing both chymase and tryptase and the other with tryptase only. PMID: 22102069
28. During breast cancer progression the mast cells may contribute to stromal remodelling and differentiation of myofibroblasts, through tryptase released in stromal microenvironment. PMID: 21707711
29. MCT gene may play a role in the pathogenesis of scar. PMID: 20540319
30. enhanced tryptase staining in media and adventitia of human and mouse abdominal aortic aneurysm lesions PMID: 21493897
31. these data show that patients suffering from active active chronic urticaria (CU) have significantly higher total tryptase levels than asymptomatic CU, atopics without CU and healthy subjects. PMID: 20718781
32. Tryptase seems to play an important role in the control of human colonic mucosal permeability, and enhanced tryptase activity was responsible for the increased permeability of rectal mucosa in irritable bowel patients PMID: 20087660
33. The levels of tryptase and chymase expression are greatly increased in human lung tissue of anaphylactic shock. PMID: 19697770
34. SPAG11B/D is both a substrate and a potent inhibitor of TPSAB1 activity. PMID: 19535787
35. mitogenic effects in human airway smooth muscle cells PMID: 11792624
36. stability and catalytic properties mediated by residues at the S1 pocket PMID: 11876641
37. structure of Bowman-Birk inhibitor derived peptides PMID: 11906611
38. Proliferative action is mediated by PAR2, COX2, prostaglandins, and PPARgamma : possible relevance to human fibrotic disorders. PMID: 12397176
39. Beta-tryptase activates peripheral blood mononuclear cells isolated from healthy donors as well as multiple sclerosis (MS) patients, inducing release of TNF-alpha, IL-6, and IL-1 beta, and is most probably an important mediator of inflammation in MS. PMID: 12742661
40. Results indicate a key role for heparin in the activation of human betaI- and beta2-tryptase. PMID: 15567416
41. Tryptase and chymase and protein levels were determined in mast cells in fibrosarcoma. PMID: 15638376
42. Mast cell tryptase cleaves protease-activated receptor 2 (PAR2) on colonocytes to increase paracellular permeability of the intestine during stress and inflammation. PMID: 16027150
43. crystal structures of both the single and the double mutant forms of recombinant human alphaI-tryptase in complex with the peptide inhibitor leupeptin, as well as the structure of the non-inhibited single mutant PMID: 16414069
44. mast cell beta-tryptase selectively cleaves asthmatic airway smooth muscle (ASM)-derived eotaxin and RANTES and abrogates their chemotactic activities, thus providing an explanation for the eosinophil paucity in asthmatic ASM bundles PMID: 16517749
45. Bikunin was found to localize on the cell membrane, while tryptase was in the secretary granules of the mast cells from psoriatic lesions. PMID: 17146627
46. Mast cell tryptase secretion into rheumatoid arthritis synovial fluid is higher than Osteoarthritis synovial fluid and stimulates the proliferation of Synovial fibrobalst-like cells. PMID: 17205215
47. The disease severity and plasma tryptase levels were not affected by the number of alpha or beta tryptase alleles in mastocytosis patients. PMID: 17449330
48. These results suggest that the characteristic neovascularization observed in pterygium may be sustained, at least in part, by mast cells angiogenic mediators, in particular tryptase. PMID: 17635650
49. siHTbeta is for the most part an inactive species and any active monomer is a consequence of heparin binding to siHTbeta under dilute conditions where unfavorable thermodynamics and/or kinetics restrict formation of active tetramer. PMID: 17655281
50. Up-regulates interleukin-8 expression in airway smooth muscle cells through a protease-activated receptor(PAR)-2-independent proteolytic mechanism. PMID: 18079491

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HGNC: 12019

OMIM: 191080

KEGG: hsa:7177

STRING: 9606.ENSP00000343577

UniGene: Hs.405479