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| Product Type | Recombinant Protein |
| Uniprot No. | O75509 |
| Species | Homo sapiens (Human) |
| Gene Names | TNFRSF21 |
| Protein Names | Recommended name: Tumor necrosis factor receptor superfamily member 21 Alternative name(s): Death receptor 6 CD_antigen= CD358 |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
| Function | Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. |
| Subcellular Location | Cell membrane, Single-pass type I membrane protein |
| Tissue Specificity | Detected in fetal spinal cord and in brain neurons, with higher levels in brain from Alzheimer disease patients (at protein level). Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, sk |
| Database Links |
HGNC: 13469 OMIM: 605732 KEGG: hsa:27242 STRING: 9606.ENSP00000296861 UniGene: Hs.443577 |
| Product Name | Recombinant Human Tumor necrosis factor receptor superfamily member 21(TNFRSF21),partial,Yeast |
| Code | CSB-YP023979HU |
| Size | Pls inquiry other sizes |
| Source | Yeast |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Protein Description | Partial |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Product Name | Recombinant Human Tumor necrosis factor receptor superfamily member 21(TNFRSF21),partial,Baculovirus |
| Code | CSB-BP023979HU |
| Size | Pls inquiry other sizes |
| Source | Baculovirus |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Protein Description | Partial |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Product Name | Recombinant Human Tumor necrosis factor receptor superfamily member 21(TNFRSF21),partial,Mammalian cell |
| Code | CSB-MP023979HU |
| Size | Pls inquiry other sizes |
| Source | Mammalian cell |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Protein Description | Partial |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
TNFRSF21 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA023979DSR2HU | TNFRSF21 Antibody | Human | ELISA, WB, IHC |
TNFRSF21 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA620280 | TNFRSF21 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA907764 | TNFRSF21 Antibody | Human | ELISA,WB |
TNFRSF21 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-EP023979HU | Recombinant Human Tumor necrosis factor receptor superfamily member 21(TNFRSF21),partial | E.coli |
| CSB-CF023979HU | Recombinant Human Tumor necrosis factor receptor superfamily member 21(TNFRSF21) | in vitro E.coli expression system |
TNFRSF21 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-EL023979HU | Human Tumor necrosis factor receptor superfamily member 21(TNFRSF21) ELISA kit | Request Information |
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