Recombinant Human Tyrosine-protein kinase SYK (SYK)

1. In this article, the authors have shown that Natural killer cells can reduce their functional role through downregulation of Syk and Zap70 kinases. PMID: 29263215
2. DFNA5 variant is associated with tobacco- and HPV-mediated oral oncogenesis. PMID: 30091681
3. This study identifies a novel signaling involving SYK/c-MYC/MALAT1 as a promising therapeutic target for the treatment of Ewing sarcoma. PMID: 28336564
4. Comparison of the distributions of tau pTyr18 and double-phosphorylated Syk in the transgenic mouse brain and human hippocampus showed that the phosphorylation of tyrosine 18 in tau already occurs at an early stage of tauopathy and increases with the progression of neurodegeneration. Syk appears unlikely to be a major kinase that phosphorylates tyrosine 18 of tau at the early stage of tauopathy. PMID: 28919467
5. Results show that Syk activation occurs following Abeta deposition and the formation of tau pathological species. As Syk activation also promotes Abeta formation and tau hyperphosphorylation, results suggest that Alzheimer's disease pathological lesions may be self-propagating via a Syk dependent mechanism highlighting Syk as an attractive therapeutic target for the treatment of Alzheimer's disease. PMID: 28877763
6. study reports that neutrophils constitutively express various Src family isoforms as well as Syk, and that inhibition of these protein tyrosine kinases selectively hinders inflammatory cytokine generation by acting posttranscriptionally PMID: 28512645
7. expressed by immune cells and keratinocytes in skin lesions of cutaneous lupus erythematosus patients PMID: 26910509
8. Cholesterol crystals activate specific cell signalling pathways which drive the production of inflammatory cytokines and degradative enzymes known to contribute to disease initiation and progression and are dependent on activation of Syk and PI3K PMID: 27356299
9. Syk-induced signals in bone marrow stromal cell lines are mediated by phospholipase C gamma1 (PLCgamma1) in osteogenesis and PLCgamma2 in adipogenesis. PMID: 28786489
10. AKT and 14-3-3 proteins down-regulate the activity of several BCR-associated components, including BTK, BLNK and SYK and also inhibit SYK's interaction with Importin 7 PMID: 27381982
11. Expression of SYK and its splice variants was significantly lower in tumors with MSI, and in KRAS wild type, BRAF mutant and PTEN mutant tumors PMID: 28957395
12. combined use of butyrate and highly specific Syk inhibitor BAY61-3606 does not enhance differentiation and apoptosis of colonocytes. Instead, BAY completely abolishes butyrate-induced differentiation and apoptosis in a Syk- and ERK1/2-dependent manner. PMID: 27293079
13. Study demonstrates that redundant complexes formed by the mutant SYK(Y3F) protein allow it to maintain signaling to receptor-proximal interaction partners, resulting in proper initiation of BCR-proximal signals. PMID: 28760774
14. The study identified the criteria for the design of binders that specifically address either the Syk or the Zap-70 Tandem Src Homology 2 Domains, tSH2. While Syk tSH2 has a rather broad substrate scope, ZAP-70 tSH2 required a proximal arrangement of the phosphotyrosine ligands in defined strand orientation. PMID: 28767218
15. SYK mediates the actions of EPO and GM-CSF and coordinates with TGF-beta in erythropoiesis. PMID: 28131718
16. study demonstrates that high SYK expression is a common feature of CD21(low) B cells independent of the underlying disorder, and that this high expression is sufficient to drive constitutive phosphorylation of SYK and its immediate targets Bruton's tyrosine kinase and phospholipase Cgamma2 PMID: 28468967
17. IgG (mAb)-opsonized, inactivated Francisella tularensis LVS enhances macrophage and dendritic cell IL-1beta responses in a TLR2- and FcgammaR-dependent fashion. FcgammaR-mediated Syk activation leads to NLRP3 inflammasome-dependent IL-1beta production in macrophages. PMID: 27365531
18. High SYK expression is associated with lymphangioleiomyomatosis. PMID: 28202529
19. NKp65 utilizes a hemi-immunoreceptor tyrosine-based activation motif -like motif for cellular activation that requires Syk, although Syk appears not to be recruited to NKp65. PMID: 28082678
20. Syk is a key regulator of Hoxa9/Meis1-driven acute myeloid leukemia. PMID: 28399410
21. Data show that spleen tyrosine kinase (SYK) and proto-oncogene protein c-akt (AKT1) proteins were increased in the cytoplasm of the cells forming Mallory-Denk bodies. PMID: 28089901
22. B cell receptor signaling component, SYK, caused PAX5 tyrosine phosphorylation in vitro and in cells. Transcriptional repression on the BLIMP1 promoter by PAX5 was attenuated by this phosphorylation. PMID: 27181361
23. Pharmacological inhibitors of SYK activity significantly reduced the engulfment of oxLDL microbeads in the presence of serum factors, but had little effect on IgG phagocytosis. PMID: 27510553
24. our data strongly suggest that AQCA-mediated suppression of inflammatory responses could be managed by a direct interference of signaling cascades including IRAK and Syk, linked to the activation of NF-kappaB and AP-1. PMID: 27338330
25. a potential link between the upregulation of Syk and VEGF-C expression and lung adenocarcinoma. PMID: 27461624
26. The lack of Syk mRNA expression in lung cancer play an important role in angiogenesis. PMID: 27461628
27. Overall novel mutations in SYK gene and in silico analysis revealed that these mutations are crucial and might be responsible for altered expression of SYK. PMID: 26889814
28. this study shows that SYK increased MUC5AC expression via ERK2 and p38 MAPK signaling pathways in airway epithelial cells PMID: 26980390
29. SYK, LYN and PTPN6 were markedly elevated in atherosclerotic plaques of carotid atherosclerosis patients. PMID: 26742467
30. Syk inhibitor suppressed the phosphorylation of band 3 also preventing serine phosphorylation changes and hemolysis. PMID: 27034738
31. SYK expression was down-regulated in laryngeal squamous cell carcinoma, which was closely correlated with cancer growth and lymph node metastasis. SYK up-regulation was able to inhibit the invasion and metastasis of LSCC. PMID: 26884848
32. TNF activates Mule by inducing the dissociation of Mule from its inhibitor ARF. Inhibition of Mule phosphorylation by silencing Syk prevents this, thereby inhibiting Mule E3 ligase activity and TNF-induced JNK activation and cell death. PMID: 26212014
33. Study establishes P-SYK as a critical biomarker in AML that identifies tumors sensitive to SYK inhibition, identifies an at-risk patient population, and allows for the monitoring of target inhibition during treatment. PMID: 26315286
34. LMPs are important pro-apoptotic regulators for Rb cells through reduction of SYK expression. PMID: 26404525
35. Data suggest that immune complexes (ICs) of FCGR3A-SYK play critical role in activation of CD4+ T-cells and thus in modulation of adaptive immunity; such ICs are present in blood from patients with systemic lupus erythematosus. PMID: 26582197
36. Syk activation is prominent in infiltrating myeloid cells in human rapidly progressive glomerulonephritis PMID: 26251216
37. Results suggest that the activated Syk-mediated TRAF6 pathway leads to aberrant activation of B cells in SLE. PMID: 25432781
38. this study shows that the treatment of cells with inducers of stress granule formation leads to the recruitment of Syk to these protein-RNA complexes PMID: 26429917
39. The differential requirements of ZAP70 and SYK during thymic development. PMID: 26187144
40. these data support the translation of approaches targeting Syk with fostamatinib to the clinic for patients with relapsed and possibly even newly diagnosed Waldenstrom macroglobulinemia PMID: 25748087
41. Syk is constitutively associated with TLR4. PMID: 25896065
42. The SYK -803 A>T genotypes TA and TT are independent risk factors for colorectal cancer development in Han Chinese in Southern China PMID: 25921550
43. Data indicate that MINCLE receptor is able to mediate the response to trehalose-6,6-dimycolate (TDM) dependent on SYK kinase and CARD9 protein. PMID: 26202982
44. find that both Syk and LMP2A have an effect on ITGbeta4 cell surface expression PMID: 25531330
45. Demonstrate role for CBL in the control of AXL/SYK/LYN network mediating resistance to nilotinib treatment in chronic myeloid leukemia cells. PMID: 25965880
46. SYK is downstream of CYR61 and contributes to CYR61-mediated mitoxantrone resistance. The CYR61-SYK pathway represents a potential target for reducing stroma-induced chemoresistance PMID: 25974135
47. Results show that paclitaxel-resistant cells expressed higher level of phospho-SYK targeting tubulins and microtubule-associated proteins. PMID: 26096845
48. An inflammatory Syk-ERK signaling axis requires DENV immune complexes, because DENV-2 in the presence of serotype-matched anti-DENV-2 mAb, but not anti-DENV-1 mAb, activates Syk, ERK, and IL-1beta secretion. PMID: 26032420
49. PRT-060318 had a significant, albeit partial, inhibitory effect, thus suggesting that ROS induce NET formation in part via activation of Syk. PMID: 25277753
50. The results reveal a Syk-dependent pathway of CpG-induced B cell stimulation, which is initiated at the plasma membrane and seems to be an upstream requirement for endosomal TLR9-driven B cell proliferation and differentiation. PMID: 25543269

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HGNC: 11491

OMIM: 600085

KEGG: hsa:6850

STRING: 9606.ENSP00000364898

UniGene: Hs.371720