Recombinant Human U1 small nuclear ribonucleoprotein 70 kDa(SNRNP70),partial

In Stock
Code CSB-EP714018HU1a0
Product Type Recombinant Protein
Size US$2466
Uniprot No. P08621
Lead Time 3-7 business days
Relevance Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Purity Greater than 85% as determined by SDS-PAGE.
Sequence MTQFLPPNLLALFAPRDPIPYLPPLEKLPHEKHHNQPYCGIAPYIREFEDPRDAPPPTRAETREERMERKRREKIERRQQEVETELKMWDPHNDPNAQGDAFKTLFVARVNYDTTESKLRREFEVYGPIKRIHMVYSKRSGKPRGYAFIEYEHERDMHSAYKHADGKKIDGRRVLVDVERGRTVKGWRPRRLGGGLGGTRRGGADVNIRH
Research Area Epigenetics and Nuclear Signaling
Source E.coli
Gene Names SNRNP70
Protein Names RNPU1Z, RPU1, SNRP70, U1AP1
Expression Region 1-210aa
Tag Info N-terminal 6xHis-tagged
Mol. Weight 28.7 kDa
Protein Description Partial
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.
Subcellular Location Nucleus, Nucleus speckle, Nucleus, nucleoplasm
Database Links

HGNC: 11150

OMIM: 180740

KEGG: hsa:6625

STRING: 9606.ENSP00000472998

UniGene: Hs.467097

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