Recombinant Human Unconventional myosin-Ic (MYO1C), partial

1. E2 and NM1 associate via their N-terminal domains and this interaction is ATP dependent. PMID: 29179037
2. The results establish a mechanistic connection between the calcium regulation of the motor function of myosin IC in the cytoplasm and the induction of its import into the nucleus. PMID: 27192697
3. NTR(35), which harbors the R21G mutation, was unable to confer MYO1C(35)-like kinetic behavior. Thus, the NTRs affect the specific nucleotide-binding properties of MYO1C isoforms, adding to their kinetic diversity. We propose that this level of fine-tuning within MYO1C broadens its adaptability within cells. PMID: 28893906
4. Cells expressing excess of MYO1C had low basal level of phosphorylated protein kinase B. PMID: 27716847
5. Upon DNA damage, an increase in the levels of chromatin bound motor protein nuclear myosin 1 (NM1) ensues, which appears to be functionally linked to Upsilon-H2AX signaling. PMID: 27365048
6. Study presents structural demonstration of a cargo protein, Neph1, attached to Myo1c, providing novel insights into the role of Myo1c in intracellular movements of this critical slit diaphragm protein. PMID: 27044863
7. In glioblastoma 1321 N1 cells, we recently identified Myo1c as a new interactor of SHIP2. SHIP2 localization at lamellipodia and ruffles is impaired in Myo1c depleted cells. In the absence of Myo1c, N1 cells tend to associate to form clusters. PMID: 27246739
8. Overexpression of MYO1C is associated with gastric cancer. PMID: 27468717
9. Ablating MYO1C function causes abnormal cholesterol distribution, which has a major selective impact on the autophagy pathway PMID: 25551774
10. Myo1c significantly increases the frequency of kinesin-1-driven microtubule-based runs that begin at actin/microtubule intersections. The actin-binding protein tropomyosin 2 abolishes Myo1c-specific effects on both run initiation and run termination. PMID: 25660542
11. NM1 phosphorylation by GSK3beta blocks NM1 ubiquitination by UBR5 and degradation by the proteasome, leads to NM1 association with the chromatin and promotes rDNA transcription activation at G1. PMID: 24901984
12. The relationship between MYO1C and KAT6B suggests that the two are interacting in chromatin remodelling for gene expression in human masseter muscle. This is the nuclear myosin1 (NM1) function of MYO1C. PMID: 24698832
13. myosin 1c manipulations lead to loss of the actin filaments and to similar endoplasmic reticulum phenotype as observed after actin depolymerization. PMID: 24523293
14. The structural context and the chemical environment of Myo1c mutations that are involved in sensorineural hearing loss in humans are described and their impact on motor function is discussed. PMID: 24636949
15. These results suggest a unique structural role for NM1 in which the interaction with SNF2h stabilizes B-WICH at the gene promoter and facilitates recruitment of the HAT PCAF PMID: 23555303
16. Both nucleolar localization signals are functional and necessary for nucleolar localization of specifically myosin IC isoform B. PMID: 23438938
17. This is the first report demonstrating that Myo1c is an important mediator of VEGF-induced VEGFR2 delivery to the cell surface and plays a role in angiogenic signaling. PMID: 23262137
18. Myo1c regulates lipid raft recycling to control cell spreading, migration and Salmonella invasion. PMID: 22328521
19. Myo1c plays a critical role in the translocation of Neph1 complexes in podocytes. Myo1c's ability to interact with membranes, F-actin, Neph1, and nephrin indicates that it actively contributes to the dynamic organization of the filtration slit. PMID: 21402783
20. NM1 facilitates maturation and accompanies export-competent preribosomal subunits to the nuclear pore complex, thus modulating export. PMID: 19729515
21. NM1 cooperates with a chromatin remodelling complex containing WSTF (Williams syndrome transcription factor) and SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A member 5 protein (SNF2h). PMID: 16514417
22. WSTF-SNF2h-NM1 forms a platform in transcription while providing chromatin remodeling PMID: 16603771

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HGNC: 7597

OMIM: 606538

KEGG: hsa:4641

STRING: 9606.ENSP00000352834

UniGene: Hs.286226