Recombinant Human Villin-1 (VIL1), partial

1. Villin, Pro-Ex-C and progesterone/estrogen receptor expression have diagnostic and predictive roles in endocervical and endometrioid adenocarcinoma. PMID: 28832070
2. Induction of cell stress alters the actin cytoskeleton in intestinal epithelial cells via changes in the actin-binding proteins villin-1 and gelsolin. PMID: 29274870
3. Villin 1 is released in plasma during acute kidney injury and shows potential as an early marker for proximal tubular injury/necrosis. PMID: 28704336
4. Villin has a higher positive expression in Primary Pulmonary Enteric Adenocarcinoma cases. Villin proved to be a very sensitive and helpful enteric marker in the differential diagnosis between PEAC and other lung adenocarcinomas. PMID: 28953659
5. villin directly interacts with a transcriptional corepressor and ligand of the Slug promoter, ZBRK1. PMID: 26658611
6. Data indicate an association between highly fucosylated glycans and caudal type homeobox 1 (CDX1) and/or villin mRNA expression that both correlate with cell differentiation. PMID: 26537799
7. study demonstrates that G. duodenalis-mediated disruption of villin is, at least, in part dependent on activation of myosin light chain kinase PMID: 26334299
8. Thus, villin plays an important role in establishing the balance between actin polymerization and actin severing to facilitate the initial steps of Salmonella entry. PMID: 25600187
9. Collective expression pattern of tensin/profilin-1/villin-1/talin could be a biomarker to estimate the prognosis of esophageal squamous cell carcinoma patients. PMID: 25337239
10. harmonin and villin autoantibodies are sensitive and specific markers of IPEX, differentiate IPEX, including atypical cases, from other early childhood disorders associated with enteropathy PMID: 24250806
11. villin immunohistochemistry is a reliable and superior adjunct in the diagnosis of microvillus inclusion disease PMID: 25517957
12. Discriminated small-cell lung carcinoma from large-cell neuroendocrine lung carcinoma with immunohistochemical markers BAI3, CDX2 and VIL1. PMID: 24266897
13. We demonstrated that the VIL1 gene is a potential candidate molecular marker for high serum AFP-associated HCC and a predictive candidate for the postoperative recurrence and poorer prognosis of HCC. PMID: 22530999
14. study confirmed finding of VIL1 as a diagnostic marker of cervical adenocarcinoma PMID: 21623163
15. identified villin, an actin-binding protein, as the 95 kDa antigen in four of five sera from patients with IPEX syndrome PMID: 21741320
16. identified VIL1 as a novel biomarker of cervical adenocarcinoma PMID: 19377296
17. villin has calcium-sensitive actin-capping and actin-depolymerizing sites PMID: 15272027
18. tyrosine phosphorylation at residues 60, 81, and 256 of human villin plays an essential role in cell migration as well as in the reorganization of the actin cytoskeleton PMID: 15342783
19. H. pylori induction of villin in the stomach correlates with activation and cooperative binding of Elk-1 and the SRF to the proximal promoter of villin PMID: 15576363
20. By severing actin filaments and capping their barbed ends, villin increases the concentration of actin monomers available for polymerization. PMID: 17182858
21. Together, our results show that in epithelial cells ATX and LPA act as strong stimulators of cell migration by recruiting PLC-gamma 1 and villin, both of which participate in the initiation of protrusion. PMID: 18054784
22. Villin is an actin regulatory protein that organizes, integrates and regulates multiple epithelial cell functions. PMID: 18307996
23. Cdx2 regulates intestinal villin expression through recruiting Brm-type SWI/SNF complex to the villin promoter. PMID: 19371634
24. Tyrosine phosphorylation of villin regulates the organization of the actin cytoskeleton PMID: 11500485

Show More

Hide All

HGNC: 12690

OMIM: 193040

KEGG: hsa:7429

STRING: 9606.ENSP00000248444

UniGene: Hs.654595