Recombinant Human Zinc finger and BTB domain-containing protein 17 (ZBTB17), partial

1. Because RPL23 is encoded by a target gene of c-Myc, the RPL23/Miz-1/c-Myc regulatory circuit provides a feedback loop that links efficient RPL23 expression with c-Myc's function to suppress Miz-1-induced Cdk inhibitors and thereby leads to apoptotic resistance in higher-risk myelodysplastic syndrome patients PMID: 28539603
2. This study firstly associates ZBTB17 loss-of-function mutation with enhanced susceptibility to DCM in humans, which provides novel insight into the molecular mechanism underpinning DCM, implying potential implications for genetic counseling and personalized management of DCM PMID: 29445930
3. These data suggest that MYC acts as a master coordinator that inversely modulates the impact of cell cycle and circadian clock on gene expression via its interaction with MIZ1. PMID: 27339797
4. strategy for the purification of tethered POZ domains that form forced heterodimers is described, and crystal structures of the heterodimeric POZ domains of Miz1/BCL6 and of Miz1/NAC1 are reported PMID: 25484205
5. Miz1 is a newly identified ING4-induced target gene which can drive prostate luminal epithelial cell differentiation. PMID: 27527891
6. The mechanism of inhibition of c-Myc transcriptional activity by Miz-1 that binds c-Myc while competing for binding with Max has been described. PMID: 27859590
7. This study used NMR to deduce the role of Miz-1 Zinc Fingers 1-4 in detecting the Miz-1 consensus sequence and preventing nonspecific DNA binding. PMID: 28035002
8. the silencing of Miz-1 expression inhibited cell proliferation and promoted apoptosis in vitro and reduced the migration ability in esophageal carcinoma cells. PMID: 27109891
9. This study presents the structure of the synthetic Miz-1 Zinc Finger 13 determined by 2D (1)H-(1)H NMR. PMID: 26972249
10. results indicate that Miz-1 may be directed in vivo to the novel motif sequences we have identified, where it can recruit its specific binding partners to control gene expression and ultimately regulate cell fate PMID: 24983942
11. MIZ-1 can promote the proliferation of breast cancer cells through Wnt signaling. PMID: 25558878
12. We demonstrate that Arnt is an interaction partner for Miz-1, and that Arnt has a functional role in the regulation of CDKN2B PMID: 24618291
13. The functional interaction of both proteins becomes apparent at oncogenic expression levels of MYC and association with MIZ-1 mediates both oncogenic functions of MYC as well as tumor-suppressive responses to oncogenic levels of MYC. PMID: 24296348
14. The ZBTB17 polymorphism rs10927875 appears to play a role in the susceptibility of the Han Chinese population to dilated cardiomyopathy . PMID: 23570452
15. The repression of TNF-alpha-induced JNK activation by Miz1 is de-repressed by its own site-specific ubiquitination and degradation. PMID: 22184250
16. study demonstrate that HPV-16 E7 forms a complex with Miz-1; These findings suggest that HPV-16 E7 protein can repress Miz-1-induced p21(Cip1) gene expression PMID: 22099967
17. NLRR3 is a direct target of MYCN, which associates with Miz-1 and negatively regulates NLRR3 expression. PMID: 21908575
18. Miz1 and Myc affect the activity of the Atr checkpoint through their effect on TopBP1 chromatin association and stability. PMID: 18923429
19. The ribosomal protein L23 is a negative regulator of Miz1-dependent transactivation. PMID: 19160485
20. These results identify an important function for BCL6 in facilitating apoptosis of germinal center B cells via suppression of BCL2, and suggest that blocking this pathway is critical for lymphomagenesis. PMID: 19549844
21. Binding of Arf disrupts the interaction of Miz1 with its coactivator, nucleophosmin, induces the sumoylation of Miz1, and facilitates the assembly of a heterochromatic complex that contains Myc and trimethylated H3K9 in addition to Miz1. PMID: 20308430
22. Miz1 BTB domain resembles a typical swapped BTB dimer, although it has a shorter N-terminus that is not able to form the interchain sheet PMID: 20493880
23. Although the transient repression mediated by Miz-1/c-Myc is independent of de novo methylation, the stable repression by this complex is associated with CpG island methylation of the critical -295 to -95-bp region of the WIF-1 promoter PMID: 20697356
24. Miz-1 acts as a p53 suppressor by interfering with p53 DNA-binding ability PMID: 19901969
25. repression of p21 promoter/reporters as well as the endogenous p21 gene by Myc depends on interaction with Miz-1. Expression of Miz-1 increases during hematopoietic differentiation and Miz-1 activates the p21 promoter under conditions of low Myc levels PMID: 12545156
26. Miz-1 has a role in inducing apoptosis along with MAGE-A4 PMID: 14739298
27. replicative senescence-specific factors may block c-Myc inhibition of Miz-1 activation of hMad4 expression, and the continual presence of hMad4 protein may transcriptionally repress selected c-Myc target genes PMID: 16167342
28. Miz-1 targeting is essential for Myc-mediated apoptosis PMID: 16352593
29. Miz-1 transcription factor was identified as an interactor of the SB transposase PMID: 16537485
30. NDRG2 expression is repressed by Myc via Miz-1-dependent interaction with the NDRG2 core promoter PMID: 17050536
31. repression of BCL2 transcription is the single essential consequence of targeting the MIZ-1 pathway during apoptosis induction, which explains a copperative interaction between c-MYC and BCL2 PMID: 17082179
32. The crystal structure of the Miz-1 POZ domain show that the beta-sheet interface directs the tetramerisation of the Miz-1 POZ domain in solution. PMID: 17880999
33. MIZ-1 is a new favorable neuroblastoma gene, which may directly or indirectly regulate the expression of other favorable neuroblastoma genes PMID: 17947461
34. Gfi-1 does not directly bind to CDKN2B, but interacts with Miz-1 and, via Miz-1, is recruited to the core promoter of CDKN2B PMID: 19164764
35. transcription factor Myc-interacting zinc-finger protein 1 (Miz1) selectively suppresses TNF-alpha-induced JNK1 activation and cell death independently. PMID: 19815509

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HGNC: 12936

OMIM: 604084

KEGG: hsa:7709

STRING: 9606.ENSP00000364895

UniGene: Hs.433764