Recombinant Human Zinc phosphodiesterase ELAC protein 2 (ELAC2), partial

Code CSB-YP859413HU
MSDS
Size Pls inquire
Source Yeast
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP859413HU
MSDS
Size Pls inquire
Source E.coli
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP859413HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-BP859413HU
MSDS
Size Pls inquire
Source Baculovirus
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-MP859413HU
MSDS
Size Pls inquire
Source Mammalian cell
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Purity
>85% (SDS-PAGE)
Target Names
ELAC2
Uniprot No.
Alternative Names
COXPD17; elaC homolog 2 (E. coli); ElaC homolog protein 2; elaC ribonuclease Z 2; elaC, E. coli, homolog of, 2; ELAC2; ELC2; FLJ10530; FLJ36693; FLJ42848; Heredity prostate cancer protein 2; HPC2; putative prostate cancer susceptibility protein HPC2/ELAC2; Ribonuclease Z 2; Ribonuclease Z, long form; Ribonuclease Z2; RNase Z 2; RNase Z2; RNase ZL; RNZ2_HUMAN; tRNA 3 endonuclease 2; tRNase Z (long form); tRNase Z 2; tRNase Z2; Zinc phosphodiesterase ELAC protein 2
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly.
Gene References into Functions
  1. This study describes the cardiac phenotype and outcome of ELAC2 mutation in Infantile Cardiomyopathy PMID: 28441660
  2. ELAC2 rs11545302 polymorphism was associated with PSA > 20 and rs4792311 was associated with TNM > 2. PMID: 27318894
  3. A homozygous splicing mutation in ELAC2 suggests phenotypic variability including intellectual disability with minimal cardiac involvement PMID: 27769300
  4. ELAC2 mutations cause a mitochondrial RNA processing defect associated with hypertrophic cardiomyopathy. PMID: 23849775
  5. results indicate that ELAC2 functions as a tRNase Z in human mitochondria and suggest that mt-tRNase Z preferentially cleaves molecules already processed by the proteinaceous mtRNase P PMID: 21593607
  6. ELAC2 and PTCD1 affect the 3' end processing of tRNAs. PMID: 21857155
  7. analysis of dual nuclear/mitochondrial targeting of the ELAC2 gene product by alternative translation initiation PMID: 21559454
  8. Data describe polymorphisms in the HPC/ELAC-2 and alpha 1-antitrypsin genes that correlate with human diseases in an Indian population. PMID: 20119870
  9. ELAC2 polymorphisms are associated with prostate cancer. PMID: 20231859
  10. Our findings corroborate the involvement of ELAC2, MSR1, and RNASEL in the etiology of prostate cancer even in individuals without a family history. PMID: 20086112
  11. variation in the putative prostate cancer susceptibility gene ELAC2 contributes to the elevated risk of prostate cancer in Afro-Caribbean males from Tobago PMID: 12384782
  12. Meta-analysis of associations of the Ser217Leu and Ala541Thr variants in ELAC2 (HPC2) and prostate cancer PMID: 12515253
  13. Although the Leu217 and Thr541 variants of ELAC2 are less common in Japanese than in Caucasians, both variants confer significantly increased risk of prostate cancer in Japanese. PMID: 12522685
  14. ELAC2 interacts with the gamma-tubulin complex and perturbation of ELAC2 might promote tumorigenesis through irregular cell division PMID: 12569551
  15. There is no evidence that either ELAC2 polymorphism is associated with prostate cancer or PSA level. PMID: 12783937
  16. polymorphism of the ELAC2 gene is associated with prostatic cancer risk in Japanese men PMID: 12949798
  17. When considering joint genotypes, white men homozygous for the Leu217 variant on an Ala541/Ala541 background had an increased risk of prostate cancer [odds ratio (OR)=1.84; 95% confidence interval (CI), 1.11-3.06]. PMID: 14504198
  18. ELAC2 has a role in prostate cancer PMID: 14625808
  19. Thr allele at 541 in HPC2/ELAC2 has strong significance in the predisposition of sporadic Pca in Japan. PMID: 15368467
  20. Single nucleotide polymorphisms associated with hereditary prostate cancer. PMID: 16114055
  21. candidate prostate cancer susceptibility gene ELAC2 potentiates TGF-beta/Smad-induced transcriptional responses PMID: 16636667
  22. The oncogenic role of HPC2 in human primary breast carcinomas is determined by its capacity to inhibit INK4a/ARF proteins(p16INK4a, p14ARF, or h-TERT) or to induce telomerase activity. PMID: 17145810
  23. Common SNPs and haplotypes of ELAC2 are associated with risk of aggressive prostate cancer. PMID: 18375959
  24. Changes in K(M) observed with some of the substitutions suggest contacts between tRNase Z and substrate tRNA in this region, and changes in tRNA structure provide an additional basis for interpretation of the kinetic effects.[tRNase Z] PMID: 18421255
  25. HPC2/ELAC2 and RNASEL may play a role, however minor, in prostate cancer risk among African American men. PMID: 18767027
  26. The findings reveal that 3' end processing is a limiting step for defective tRNA maturation and demonstrate that overexpression of ELAC2 can promote defective tRNA 3' processing in vivo. PMID: 19555350
  27. The present data suggest the possibility that human cytosolic tRNase ZL modulates gene expression through a subset of microRNAs in the cells. PMID: 19751732
  28. Observational study and meta-analysis of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 15824169
  29. ELAC2 harbors mutations (including a frameshift and a nonconservative missense change) that segregate with prostate cancer in two Utah pedigrees PMID: 11175785

Show More

Hide All

Involvement in disease
Prostate cancer, hereditary, 2 (HPC2); Combined oxidative phosphorylation deficiency 17 (COXPD17)
Subcellular Location
Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid. Nucleus. Note=Mainly mitochondrial.
Protein Families
RNase Z family
Tissue Specificity
Widely expressed. Highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis and ovary. Weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon and leukocytes.
Database Links

HGNC: 14198

OMIM: 176807

KEGG: hsa:60528

STRING: 9606.ENSP00000337445

UniGene: Hs.434232

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1