Recombinant Influenza B virus Nuclear export protein(NS)

In Stock
Code CSB-EP362296IJZa0
Product Type Recombinant Protein
Uniprot No. P08014
Storage Buffer Tris-based buffer,50% glycerol
Species Influenza B virus (strain B/Yamagata/1/1973)
Purity Greater than 85% as determined by SDS-PAGE.
Research Area Microbiology
Source E.coli
Gene Names NS
Expression Region 1-122aa
Tag Info N-terminal 6xHis-tagged
Mol. Weight 18.4 kDa
Protein Description Full Length
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs bound to the protein M1. Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced.
Subcellular Location Virion, Host nucleus
Protein Families Influenza viruses NEP family

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