Recombinant Macaca fascicularis Amyloid beta A4 protein(APP) ,partial

Code CSB-YP001950MOV1
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Source Yeast
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Code CSB-EP001950MOV1
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Source E.coli
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Code CSB-EP001950MOV1-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP001950MOV1
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Source Baculovirus
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Code CSB-MP001950MOV1
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names APP
Uniprot No. P53601
Alternative Names APP; QccE-15949Amyloid-beta A4 protein; ABPP; APP; Alzheimer disease amyloid A4 protein homolog; Amyloid precursor protein; Amyloid-beta precursor protein) [Cleaved into: N-APP; Soluble APP-alpha; S-APP-alpha); Soluble APP-beta; S-APP-beta); C99; Beta-secretase C-terminal fragment; Beta-CTF); Amyloid-beta protein 42; Abeta42; Beta-APP42); Amyloid-beta protein 40; Abeta40; Beta-APP40); C83; Alpha-secretase C-terminal fragment; Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59; Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57; Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50; Gamma-CTF(50)); C31]
Species Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP (By similarity). Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). May be involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation (By similarity). Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV (By similarity). The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 (By similarity).
Gene References into Functions
  1. These findings highlight the role of neuronal exosomes in Abeta clearance, and suggest that their downregulation might relate to Abeta accumulation and, ultimately, the development of AD pathology. PMID: 25436414
Subcellular Location Membrane, Single-pass type I membrane protein, Membrane, clathrin-coated pit
Protein Families APP family
Database Links

KEGG: mcf:101926433

UniGene: Mfa.1063

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  Email: [email protected]
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