Recombinant Mouse 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (Plce1), partial

1. The first SNP rs29972765 is located in a gene desert on chromosome 18, about 72 kb upstream of Skor2 . The second SNP rs30415957 resides in the intron of Plce1.The remaining two SNPs (rs30768258 and rs31216810) are close to each other on chromosome 19, in the vicinity of Sorbs1. Knockdown of Sorbs1 by siRNA attenuates the induction of differentiation marker gene Prl8a2 PMID: 27449513
2. 2-arachidonoylglycerol (2-AG) is an endogenous cannabinoid that depresses synaptic transmission through stimulation of CB1 receptors. Among the six isoforms of phospholipase C (PLC; PLCbeta, PLCgamma, PLCdelta, PLCepsilon, PLCzeta, PLCeta), only PLCbeta has been linked to 2-AG synthesis. Here we demonstrate that 8-CPT-2Me-cAMP, a selective agonist of the cAMP sensor protein Epac, enhances 2-AG-mediated synaptic depress... PMID: 28209735
3. study shed light on a novel role of PLCepsilon in wound healing and provided new therapeutic approaches to target PLCepsilon for diminishing scar formation after injury PMID: 28093232
4. PLCepsilon is crucial for N-butyl-N-(4-hydroxybutyl) nitrosamine induced bladder carcinogenesis. PMID: 26782701
5. Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase C epsilon. PMID: 26350460
6. PLCepsilon plays an important role in the pathogenesis of bronchial asthma through upregulating inflammatory cytokine production by the bronchial epithelial cells. PMID: 25269075
7. a new pathway for TRPC6 activation by Phospholipase C epsilon PMID: 25521631
8. findings reveal a pathway initiated by GPCR agonist-induced RhoA activation, in which PLCepsilon signals to PKD1-mediated phosphorylation of cytoskeletal proteins PMID: 24345679
9. Activity of PLCepsilon contributes to chemotaxis of fibroblasts towards PDGF. PMID: 22992460
10. PLCepsilon links G protein-coupled receptors (GPCR) to sustained PKD activation, providing a means for GPCR ligands that couple to RhoA to induce NF-kappaB signaling and promote neuroinflammation. PMID: 23401561
11. These results reveal a crucial role of PLCepsilon in the development of skin inflammation and suggest a mechanism in which PLCepsilon induces the production of cytokines including IL-23 from keratinocytes, leading to the activation of IL-22-producing T cells. PMID: 21182091
12. results indicate that PLCvarepsilon has a crucial role in UVB-induced acute inflammatory reactions such as neutrophil infiltration and epidermal thickening by at least in part regulating expression of CXCL1/KC in skin cells such as keratinocytes and fibroblasts PMID: 21321537
13. PLCepsilon may be a key molecule regulating the signal pathway of bladder cancer proliferation PMID: 21121899
14. Phospholipase c-epsilon is a determinant of mouse islet insulin secretion that is under the control of Epac2. PMID: 21478675
15. resistance to UVB-induced cell death conferred by the absence of PLCepsilon is closely related to the higher incidence of skin tumor formation. PMID: 20688835
16. PLCepsilon plays a crucial role in induction of proinflammatory cytokine expression in fibroblasts and keratinocytes at the challenged sites PMID: 20007527
17. the induction of phospholipase Cepsilon expression may be a specific event associated with the commitment of the neural precursor cells to the neuronal lineage. PMID: 12752375
18. Phospholipase C epsilon acts downstream of the epidermal growth factor receptor in controlling semilunar valvulogenesis through inhibition of bone morphogenetic protein signaling. PMID: 15743817
19. GPCR agonists ET-1, LPA, and thrombin activate PLCepsilon and PLCbeta3 in fibroblasts. Activation of these PLC isoforms displays agonist-specific temporal profiles; PLCbeta3 is predominantly involved in acute and PLCepsilon in sustained PI hydrolysis PMID: 16314422
20. Phospholipase Cepsilon has a role in Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation PMID: 17878312
21. PLC epsilon activation is involved in skin inflammation. PMID: 18172297
22. control of sarcoplasmic reticulum Ca2+ release, rather than Ca2+ influx through L-type Ca2+ channels, is the target of regulation of a novel signal transduction pathway involving activation of Epac, PLCepsilon, PKCepsilon, and CamKII PMID: 18957419
23. Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc(Min/+) mice through augmentation of inflammation and angiogenesis. PMID: 19458037

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KEGG: mmu:74055

STRING: 10090.ENSMUSP00000130604

UniGene: Mm.34031